Product image of Mycostatin (Nystatin) supplied by GNH India

Mycostatin

Active Ingredient:
Nystatin
Origin:
EU

Mycostatin (Nystatin)

Nystatin, the active ingredient in Mycostatin, is a polyene antifungal presented as an oral formulation for oral use. It treats oral, esophageal and gastrointestinal candidiasis in patients with confirmed fungal infection.

GNH India supplies Mycostatin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Substipharm

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Indications & Clinical Uses

Mycostatin is a polyene antifungal indicated for Candida infections of the oral and gastrointestinal tracts.

  • Oral candidiasis (thrush): reduces fungal load and resolves oral lesions.
  • Esophageal candidiasis: treats infection and alleviates dysphagia.
  • Gastrointestinal candidiasis: eradicates Candida overgrowth in the GI tract.

How It Works

  • Nystatin binds selectively to ergosterol, a key sterol in fungal cell membranes. This interaction creates pores that increase membrane permeability, leading to leakage of intracellular components and ultimately fungal cell death without affecting human cells that lack ergosterol.

Side Effects

Adverse reactions may occur with Mycostatin use.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Vomiting: occasional episodes after dosing.
  • Abdominal discomfort: cramping or pain.
  • Diarrhea: loose stools.
  • Altered taste: metallic or unpleasant flavor.
  • Mild skin rash: localized erythema.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Hepatic dysfunction: signs of liver injury such as jaundice.
  • Severe neutropenia: marked reduction in white blood cells.
  • Stevens‑Johnson syndrome: severe skin and mucous membrane reaction.
  • Severe mucosal ulceration: extensive ulcer formation in the mouth or esophagus.
  • Systemic fungal infection: rare dissemination of Candida.

Precautions & Warnings

Before prescribing Mycostatin, clinicians should consider several safety measures.

  • Assess renal function: adjust use in severe impairment.
  • Monitor for allergic reactions: discontinue if severe hypersensitivity occurs.
  • Evaluate hepatic status: use cautiously in liver disease.
  • Confirm Candida infection: avoid unnecessary exposure.
  • Avoid concomitant nephrotoxic drugs: increase renal monitoring.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Mycostatin may interact with other medicines; awareness of major and moderate interactions helps ensure safety.

Major Interactions (Avoid)

  • Concomitant nephrotoxic antibiotics (e.g., amphotericin B): increased renal toxicity.
  • Co‑administration with live oral vaccines: risk of disseminated infection.
  • Use with systemic azole antifungals: antagonistic effect reducing nystatin efficacy.

Moderate Interactions (Monitor Closely)

  • Antacids containing aluminum or magnesium: may decrease oral absorption.
  • Broad‑spectrum antibiotics: can alter gut flora and affect Candida balance.
  • Oral contraceptives: possible reduction in hormonal effectiveness.

Frequently Asked Questions

Mycostatin is an oral polyene antifungal indicated for the treatment of Candida infections, specifically oral thrush, esophageal candidiasis, and gastrointestinal candidiasis. It is prescribed when a fungal overgrowth of Candida species has been confirmed, helping to clear infection and relieve associated symptoms.

Nystatin binds to ergosterol, a sterol unique to fungal cell membranes. This binding creates pores that increase membrane permeability, causing leakage of essential intracellular components and leading to fungal cell death while sparing human cells that lack ergosterol.

The exact dose of Mycostatin is determined by the prescribing clinician based on the type and severity of the Candida infection, patient age, weight, and renal or hepatic function. Typical regimens vary, and the prescriber will provide specific dosing instructions tailored to the individual.

Safety data for Nystatin in pregnancy and lactation are limited. It is generally considered low risk because of minimal systemic absorption, but clinicians should evaluate the potential benefits against any possible risks and discuss options with the patient before prescribing.

To order Mycostatin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Mycostatin (nystatin) is a polyene antifungal that acts locally in the gastrointestinal tract and has minimal systemic absorption, making it suitable for mucosal Candida infections. Azole agents (e.g., fluconazole) are systemically absorbed and used for deeper or invasive infections, but may have more drug‑drug interactions and resistance concerns.

Store Mycostatin at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability throughout its shelf life.

Mycostatin is taken orally, usually as a suspension or tablet, as directed by the prescriber. It should be swallowed with water or mixed with a suitable vehicle if a suspension, and the full course should be completed even if symptoms improve early.

Serious adverse reactions, though rare, include severe allergic responses such as anaphylaxis, hepatic dysfunction, marked neutropenia, Stevens‑Johnson syndrome, and extensive mucosal ulceration. Patients should seek immediate medical attention if they experience signs of a severe reaction.

Mycostatin is contraindicated in individuals with a known hypersensitivity to nystatin or any component of the formulation. Caution is also advised for patients with severe renal impairment, active liver disease, or those receiving live oral vaccines, as these conditions may increase risk of adverse effects.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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