Product image of Mydrane (Lidocaine Hydrochloride Monohydrate, Phenylephrine Hydrochloride, Tropicamide) supplied by GNH India

Mydrane

Active Ingredient:
Lidocaine Hydrochloride Monohydrate, Phenylephrine Hydrochloride, Tropicamide
Origin:
EU

Mydrane (Lidocaine Hydrochloride Monohydrate, Phenylephrine Hydrochloride, Tropicamide)

Lidocaine Hydrochloride, Phenylephrine Hydrochloride, Tropicamide, the active ingredient in Mydrane, is a local anesthetic; alpha‑adrenergic agonist; anticholinergic presented as an intracameral solution for intra‑ocular use. It provides rapid pupil dilation and anesthesia during cataract and other intra‑ocular surgeries.
GNH India supplies Mydrane as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoires Thea

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Indications & Clinical Uses

Mydrane acts on the ocular anterior segment to facilitate surgical procedures.

  • Cataract surgery: rapid pupil dilation and intra‑ocular anesthesia to enable safe lens removal.
  • Other intra‑ocular surgery: provides mydriasis and analgesia for procedures such as trabeculectomy or vitrectomy.
  • Anterior segment procedures: assists with anesthesia and dilation during corneal transplants and iridectomy.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels in ocular nerves, producing local anesthesia. Phenylephrine stimulates alpha‑1 adrenergic receptors on the iris dilator muscle, causing contraction and pupil enlargement. Tropicamide antagonizes muscarinic receptors in the iris sphincter muscle, preventing constriction. The combined actions yield swift intra‑ocular anesthesia and sustained mydriasis when administered intracamerally.

Side Effects

Mydrane may cause ocular and systemic reactions after administration.

Common Side Effects

  • Transient ocular pain or discomfort.
  • Temporary increase in intra‑ocular pressure.
  • Mild corneal edema or haze.
  • Slight anterior chamber inflammation.
  • Blurred vision lasting a few hours.
  • Headache or mild systemic flushing.

Serious or Rare Side Effects

  • Allergic reaction with rash, itching, or anaphylaxis.
  • Persistent or uncontrolled mydriasis.
  • Severe hypotension or cardiovascular instability.
  • Retinal toxicity or vision loss.
  • Endophthalmitis or severe intra‑ocular infection.
  • Significant ocular inflammation requiring intervention.

Precautions & Warnings

Mydrane should be used with careful patient assessment and monitoring.

  • Allergy assessment: avoid in patients with known hypersensitivity to any component.
  • Intra‑ocular pressure: monitor before and after injection, especially in glaucoma patients.
  • Cardiovascular status: use cautiously in patients with uncontrolled hypertension or cardiac disease.
  • Ocular infection: contraindicated in active intra‑ocular infections.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at controlled room temperature: keep in original packaging, protect from light and moisture.

Avoid Interactions

Mydrane may interact with other ocular or systemic agents.

Major Interactions (Avoid)

  • Concurrent use of other potent mydriatics may cause excessive pupil dilation and iris ischemia.
  • Simultaneous administration of additional local anesthetics can increase risk of ocular toxicity.

Moderate Interactions (Monitor Closely)

  • Systemic alpha‑adrenergic agonists may augment cardiovascular effects of phenylephrine.
  • Anticholinergic drugs can potentiate tropicamide‑related systemic anticholinergic effects.
  • Beta‑blocker eye drops may blunt intra‑ocular pressure response.
  • NSAID eye drops may affect inflammation profile when used together.

Frequently Asked Questions

Mydrane is an intracameral ophthalmic solution used to provide rapid pupil dilation and local anesthesia during cataract surgery, other intra‑ocular procedures, and anterior segment operations. It helps surgeons achieve a clear surgical field and patient comfort.

Lidocaine blocks sodium channels to numb ocular nerves, phenylephrine activates alpha‑1 receptors causing the iris dilator muscle to contract, and tropicamide blocks muscarinic receptors preventing the iris sphincter from constricting. Together they produce quick, sustained mydriasis and anesthesia.

The dose of Mydrane is determined by the operating ophthalmologist based on the specific surgical procedure and patient factors. The prescriber selects the appropriate volume to inject intracamerally at the time of surgery.

Safety of Mydrane in pregnancy or lactation has not been established. Clinicians should consider the potential benefits against unknown risks and may choose alternative agents when treating pregnant or nursing patients.

To order Mydrane, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mydrane combines a local anesthetic with two mydriatic agents, offering both anesthesia and dilation in a single injection. Compared with single‑agent mydriatics, it reduces the need for multiple drops and provides faster, more predictable pupil dilation during surgery.

Mydrane should be stored at controlled room temperature, kept in its original sealed container, protected from light and moisture. Do not freeze the solution and handle it using aseptic techniques to maintain sterility.

Mydrane is administered by the surgeon as an intracameral injection directly into the anterior chamber of the eye at the start of the procedure. The injection is performed under sterile conditions in the operating theatre.

Serious risks include severe allergic reactions, persistent mydriasis, significant intra‑ocular pressure spikes, retinal toxicity, and endophthalmitis. Prompt recognition and management of these events are essential to prevent lasting ocular damage.

Mydrane is contraindicated in patients with known hypersensitivity to lidocaine, phenylephrine, tropicamide, or any excipients, as well as in eyes with active intra‑ocular infection, uncontrolled glaucoma, or severe cardiovascular disease where systemic alpha‑adrenergic effects could be harmful.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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