Product image of Mydrane (Lidocaine Hydrochloride Monohydrate, Phenylephrine Hydrochloride, Tropicamide) supplied by GNH India

Mydrane

Active Ingredient:
Lidocaine Hydrochloride Monohydrate, Phenylephrine Hydrochloride, Tropicamide
Origin:
EU

Mydrane (Lidocaine Hydrochloride Monohydrate, Phenylephrine Hydrochloride, Tropicamide)

Lidocaine Hydrochloride Monohydrate, Phenylephrine Hydrochloride, Tropicamide, the active ingredient in Mydrane, is a combination ophthalmic agent presented as a solution for intracameral injection use. It provides intra‑operative pupil dilation and local anesthesia during cataract surgery.

GNH India supplies Mydrane as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoires Thea

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Indications & Clinical Uses

  • Mydrane is used in ophthalmic procedures to achieve rapid pupil dilation and intra‑ocular anesthesia.
  • Cataract surgery: provides intra‑operative pupil dilation and anesthesia of the anterior segment.
  • Anterior segment surgery: facilitates pupil dilation and reduces intra‑operative discomfort.
  • Intra‑ocular lens implantation: ensures adequate mydriasis and analgesia during lens placement.

How It Works

  • Lidocaine blocks voltage‑gated sodium channels in ocular nerves, producing local anesthesia. Phenylephrine activates α1‑adrenergic receptors on the iris dilator muscle, causing contraction and pupil enlargement. Tropicamide antagonizes muscarinic receptors in the iris sphincter muscle, leading to relaxation and further dilation. The combined actions result in rapid, sustained mydriasis and analgesia for intra‑operative use.

Side Effects

Common Side Effects

  • Transient ocular pain or discomfort.
  • Increased intra‑ocular pressure shortly after injection.
  • Conjunctival hyperemia or redness.
  • Corneal edema or mild clouding.
  • Blurred vision lasting a few hours.
  • Mild anterior chamber reaction.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis) requiring emergency care.
  • Persistent mydriasis lasting beyond the surgical period.
  • Acute uveitis or intra‑ocular inflammation.
  • Retinal detachment.
  • Endophthalmitis (intra‑ocular infection).
  • Systemic toxicity from lidocaine (e.g., CNS symptoms).

Precautions & Warnings

Before using Mydrane, consider the following precautions:

  • Assess ocular health: ensure no active infection or inflammation.
  • Avoid in patients with known hypersensitivity to any component.
  • Monitor intra‑ocular pressure: watch for postoperative spikes.
  • Use caution in patients with narrow‑angle glaucoma.
  • Avoid concurrent use of other mydriatic agents unless clinically required.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Mydrane may interact with other medications as follows:

Major Interactions (Avoid)

  • Systemic alpha‑adrenergic agonists: may cause excessive hypertension.
  • Other topical mydriatics: risk of prolonged pupil dilation.
  • Cholinergic antagonists: additive antimuscarinic effect.

Moderate Interactions (Monitor Closely)

  • Topical NSAIDs: may increase risk of corneal edema.
  • Beta‑blocker eye drops: monitor intra‑ocular pressure.
  • Systemic lidocaine: additive local anesthetic effect.

Frequently Asked Questions

Mydrane is an intracameral ophthalmic solution used during cataract and other anterior segment surgeries to rapidly dilate the pupil and provide local anesthesia of the intra‑ocular structures, facilitating a safe and comfortable operative environment.

Lidocaine blocks sodium channels to numb ocular nerves, phenylephrine stimulates α1‑adrenergic receptors causing the iris dilator muscle to contract, and tropicamide blocks muscarinic receptors, relaxing the iris sphincter. Together they produce quick, sustained pupil dilation and analgesia.

The dose of Mydrane is determined by the operating ophthalmologist based on the specific surgical protocol and patient factors. It is administered as a single intracameral injection at the start of the procedure.

Safety data for Mydrane in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the prescribing clinician.

To order Mydrane, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Mydrane combines a local anesthetic with two mydriatic agents in a single injection, offering rapid and sustained dilation plus analgesia. Compared with separate topical drops, it reduces preparation time and may provide more consistent pupil size, though choice depends on surgeon preference and patient characteristics.

Mydrane should be stored at ambient temperature, protected from light and moisture, and kept in its original sealed container until use. Do not freeze the solution and discard any product that appears discolored or contaminated.

Mydrane is administered by the surgeon as a single intracameral injection into the anterior chamber of the eye at the beginning of the procedure, using aseptic technique and appropriate injection equipment.

Serious risks include severe allergic reactions, persistent mydriasis, acute uveitis, retinal detachment, endophthalmitis, and systemic lidocaine toxicity. Prompt recognition and management of these events are essential.

Mydrane should not be used in patients with known hypersensitivity to lidocaine, phenylephrine, tropicamide, or any excipients, nor in eyes with active infection, severe inflammation, or uncontrolled narrow‑angle glaucoma. Contraindications must be assessed by the treating ophthalmologist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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