Product image of Mydriasert (Phenylephrine Hydrochloride, Tropicamide) supplied by GNH India

Mydriasert

Active Ingredient:
Phenylephrine Hydrochloride, Tropicamide
Origin:
EU

Mydriasert (Phenylephrine Hydrochloride, Tropicamide)

Phenylephrine Hydrochloride and Tropicamide, the active ingredients in Mydriasert, are mydriatic agents presented as an ophthalmic solution for ocular use. They work together to dilate the pupil and temporarily paralyze accommodation, facilitating detailed eye examinations and surgical procedures.
GNH India supplies Mydriasert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Thea

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Indications & Clinical Uses

Mydriasert, a combination mydriatic eye drop, is used in ophthalmic settings where pupil dilation is required.

  • Pharmacologic pupil dilation for ophthalmic examinations: provides adequate dilation for detailed retinal evaluation.
  • Facilitation of intra‑ocular surgery: enables sufficient pupil enlargement for surgical access.
  • Diagnostic mydriasis: supports diagnostic procedures that require a clear view of intra‑ocular structures.

How It Works

  • Phenylephrine hydrochloride acts as an alpha‑1 adrenergic agonist, contracting the dilator pupillae muscle, while tropicamide blocks muscarinic receptors on the sphincter pupillae muscle, producing cycloplegia. The combined action results in rapid and sustained pupil dilation and loss of accommodation, facilitating ocular assessment and surgery.

Side Effects

Mydriasert may cause ocular and systemic reactions after administration.

Common Side Effects

  • Transient ocular discomfort or stinging sensation.
  • Blurred vision lasting several hours.
  • Photophobia due to enlarged pupil.
  • Mild conjunctival hyperemia.
  • Temporary increase in intra‑ocular pressure.

Serious or Rare Side Effects

  • Acute angle‑closure glaucoma.
  • Severe allergic reaction (e.g., angio‑edema, anaphylaxis).
  • Corneal edema.
  • Systemic hypertension or tachycardia.
  • Ocular ischemia or retinal vascular events.

Precautions & Warnings

Before using Mydriasert, consider the following safety measures.

  • Assess baseline intra‑ocular pressure: measure IOP prior to administration.
  • Avoid use in patients with narrow‑angle glaucoma: contraindicated due to risk of angle‑closure.
  • Use with caution in patients with cardiovascular disease: monitor blood pressure and heart rate.
  • Do not combine with other mydriatic agents unless directed by a clinician.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Mydriasert can interact with systemic and ocular medications.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): may precipitate hypertensive crisis.
  • Systemic sympathomimetics (e.g., epinephrine): additive cardiovascular stimulation.

Moderate Interactions (Monitor Closely):\n- Other ocular mydriatics: may cause excessive pupil dilation.

  • Anticholinergic drugs: increased cycloplegic effect.
  • Topical corticosteroids: potential for elevated intra‑ocular pressure.

Frequently Asked Questions

Mydriasert is an ophthalmic solution containing phenylephrine hydrochloride and tropicamide. It is used to pharmacologically dilate the pupil and induce cycloplegia, facilitating detailed eye examinations, intra‑ocular surgeries, and diagnostic procedures that require a clear view of the interior of the eye.

Phenylephrine hydrochloride is an alpha‑1 adrenergic agonist. By stimulating alpha‑1 receptors on the dilator pupillae muscle, it causes contraction of this muscle, leading to pupil dilation. When combined with tropicamide, the overall effect is a rapid and sustained mydriasis suitable for ophthalmic use.

The dosing regimen for Mydriasert is determined by the prescribing ophthalmologist based on the specific clinical need, patient age, and ocular condition. The prescriber will specify the number of drops, timing, and any repeat applications required for the intended procedure.

Safety data for Mydriasert in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant. Clinicians should evaluate each case individually and discuss possible risks with the patient.

To order Mydriasert, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including any cold‑chain requirements), and import documentation.

Mydriasert combines an alpha‑1 agonist (phenylephrine) with an antimuscarinic (tropicamide), providing both dilator and cycloplegic effects in a single formulation. Compared with single‑agent drops such as phenylephrine alone or tropicamide alone, Mydriasert often achieves faster and more complete dilation, reducing the need for multiple applications.

Mydriasert should be stored at room temperature, below 25 °C, in its original container. Protect the solution from direct light and moisture. Do not freeze the product, and keep the cap tightly closed when not in use to maintain sterility.

Mydriasert is applied topically to the eye as a sterile ophthalmic solution. The prescriber will instruct the patient or healthcare professional on the number of drops per eye, the interval between doses, and any necessary precautions such as avoiding contact with other surfaces.

The most serious risks include acute angle‑closure glaucoma, severe allergic reactions (including anaphylaxis), and significant increases in intra‑ocular pressure that could threaten vision. Patients should be monitored closely for signs of pain, visual changes, or systemic hypertension after administration.

Mydriasert is contraindicated in patients with known hypersensitivity to phenylephrine, tropicamide, or any excipients in the formulation. It should also be avoided in individuals with narrow‑angle or closed‑angle glaucoma, uncontrolled hypertension, or severe cardiovascular disease unless directed by a specialist.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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