Product image of Mydriasert (Phenylephrine Hydrochloride, Tropicamide) supplied by GNH India

Mydriasert

Active Ingredient:
Phenylephrine Hydrochloride, Tropicamide
Origin:
EU

Mydriasert (Phenylephrine Hydrochloride, Tropicamide)

Phenylephrine Hydrochloride, the active ingredient in Mydriasert, is a mydriatic agent presented as an ophthalmic solution for ocular use. It, together with tropicamide, produces rapid pupil dilation to facilitate diagnostic eye examinations and ophthalmic procedures.

GNH India supplies Mydriasert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Thea

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Indications & Clinical Uses

  • Mydriasert, a combination mydriatic eye drop, is used in ophthalmology to achieve pupil dilation.
  • Diagnostic eye examinations: provides sufficient mydriasis to allow thorough retinal evaluation.
  • Ophthalmic surgery: creates a wide pupil for better intra‑operative visualization.
  • Laser ophthalmic procedures: enables adequate exposure of the treatment area during laser therapy.

How It Works

  • Phenylephrine hydrochloride acts as a direct alpha‑1 adrenergic agonist, contracting the radial iris dilator muscle, while tropicamide blocks muscarinic receptors in the sphincter muscle, preventing constriction. The concurrent stimulation of dilation and inhibition of constriction results in rapid and sustained pupil enlargement for ophthalmic assessment and procedures.

Side Effects

Mydriasert may cause ocular and systemic reactions after administration.

Common Side Effects

  • Transient blurred vision
  • Mild ocular discomfort or stinging
  • Conjunctival redness
  • Photophobia
  • Temporary increase in intra‑ocular pressure
  • Mild headache

Serious or Rare Side Effects

  • Acute angle‑closure glaucoma
  • Severe allergic reaction (e.g., rash, swelling)
  • Systemic hypertension or tachycardia
  • Cardiac arrhythmia
  • Ocular inflammation or infection
  • Persistent mydriasis beyond expected duration

Precautions & Warnings

  • Before using Mydriasert, consider the following safety measures.
  • Assess intra‑ocular pressure: verify baseline pressure to avoid exacerbating glaucoma.
  • Avoid in narrow‑angle glaucoma: risk of angle‑closure attacks.
  • Use cautiously in hypertensive patients: monitor blood pressure for systemic effects.
  • Monitor children closely: systemic absorption may be higher.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Mydriasert can interact with other medications; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Systemic alpha‑adrenergic agonists (e.g., phenylephrine nasal spray): additive cardiovascular stimulation.
  • Concurrent mydriatic agents: risk of excessive pupil dilation.
  • Monoamine oxidase inhibitors: potential hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Anticholinergic drugs: enhanced mydriatic effect.
  • Topical beta‑blocker eye drops: may influence intra‑ocular pressure control.
  • Local anesthetic eye drops: increased ocular irritation risk.

Frequently Asked Questions

Mydriasert is an ophthalmic solution containing phenylephrine hydrochloride and tropicamide. It is used to produce rapid pupil dilation (mydriasis) during diagnostic eye examinations, ophthalmic surgeries, and laser procedures, allowing clinicians to view the interior structures of the eye more clearly.

Phenylephrine acts as a direct alpha‑1 adrenergic agonist. By stimulating alpha‑1 receptors on the radial iris dilator muscle, it causes the muscle to contract, pulling the iris outward and widening the pupil. This effect, combined with tropicamide’s antimuscarinic action, results in effective mydriasis.

The specific dose of Mydriasert is determined by the prescribing clinician based on the patient’s age, clinical situation, and the required degree of dilation. Typically, one drop is instilled in the target eye(s) and may be repeated after a short interval if additional dilation is needed.

Safety data for Mydriasert in pregnancy and lactation are limited. It should only be used when the potential benefit justifies any possible risk to the fetus or infant. Healthcare providers should evaluate the individual situation before prescribing to pregnant or nursing patients.

To order Mydriasert, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details, and any necessary import documentation.

Mydriasert combines a direct alpha‑1 agonist (phenylephrine) with an antimuscarinic (tropicamide), providing faster and more predictable dilation than single‑agent drops such as atropine or cyclopentolate. The combination often requires fewer applications and yields a shorter recovery time, though individual patient response may vary.

Mydriasert should be stored at room temperature, below 25 °C, in its original packaging. Protect the container from light, moisture, and extreme temperatures. Keep the product out of reach of children and discard any solution that appears discolored or contaminated.

Mydriasert is applied as an ocular drop. The patient or clinician places the prescribed number of drops into the conjunctival sac of the intended eye(s). The eye should be gently closed for a few seconds to allow absorption, and any excess liquid can be wiped away with a clean tissue.

The most serious risks include acute angle‑closure glaucoma, severe systemic hypertension, and rare allergic reactions such as anaphylaxis. Patients with a history of narrow‑angle glaucoma or uncontrolled cardiovascular disease should be monitored closely, and any signs of severe pain, vision loss, or systemic symptoms require immediate medical attention.

Mydriasert is contraindicated in individuals with known hypersensitivity to phenylephrine, tropicamide, or any excipients in the formulation. It should also be avoided in patients with narrow‑angle or acute angle‑closure glaucoma, severe uncontrolled hypertension, and certain cardiovascular conditions unless specifically directed by a qualified eye care professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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