Product image of Mydriasert (Phenylephrine Hydrochloride, Tropicamide) supplied by GNH India

Mydriasert

Active Ingredient:
Phenylephrine Hydrochloride, Tropicamide
Origin:
EU

Mydriasert (Phenylephrine Hydrochloride, Tropicamide)

Phenylephrine Hydrochloride/Tropicamide, the active ingredient in Mydriasert, is a mydriatic agent presented as an ophthalmic solution for ocular use. It induces rapid pupil dilation to facilitate diagnostic eye examinations and fundus evaluation in patients of all ages.

GNH India supplies Mydriasert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Thea

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Indications & Clinical Uses

Mydriasert, containing phenylephrine hydrochloride and tropicamide, is employed in ophthalmology to achieve pharmacologic mydriasis for diagnostic purposes.

  • Diagnostic eye examination: provides rapid pupil dilation to allow thorough retinal and optic nerve assessment.
  • Fundus photography: facilitates clear imaging of the retina and macula.
  • Pre‑operative ocular assessment: enables evaluation of intra‑ocular structures before surgery.

How It Works

  • Phenylephrine hydrochloride acts as an alpha‑1 adrenergic receptor agonist, contracting the radial iris dilator muscle, while tropicamide blocks muscarinic receptors, inhibiting the sphincter pupillae muscle. The combined action relaxes the constrictor and contracts the dilator, producing swift and sustained pupil dilation for ocular evaluation.

Side Effects

Mydriasert may cause a range of ocular and systemic reactions.

Common Side Effects

  • Transient ocular discomfort or stinging on instillation.
  • Blurred vision lasting several hours.
  • Photophobia due to enlarged pupil.
  • Mild conjunctival hyperemia.
  • Temporary increase in intra‑ocular pressure.
  • Headache.

Serious or Rare Side Effects

  • Acute angle‑closure glaucoma.
  • Severe allergic reaction (e.g., angio‑edema, anaphylaxis).
  • Systemic hypertension or tachycardia.
  • Persistent mydriasis.
  • Corneal edema.
  • Retinal detachment (very rare).

Precautions & Warnings

Before using Mydriasert, consider the following safety measures.

  • Assess intra‑ocular pressure: avoid in patients with narrow‑angle glaucoma.
  • Screen for hypersensitivity: discontinue if allergic signs appear.
  • Use with caution in cardiovascular disease: phenylephrine may raise blood pressure.
  • Avoid in pediatric patients unless specifically directed: limited safety data.
  • Monitor for systemic absorption, especially in patients on monoamine oxidase inhibitors.
  • Store at below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Mydriasert can interact with several systemic and ocular agents.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: risk of hypertensive crisis.
  • Systemic alpha‑adrenergic agonists: additive pressor effects.
  • Concurrent mydriatics: may cause excessive pupil dilation.

Moderate Interactions (Monitor Closely)

  • Beta‑blocker eye drops: may reduce intra‑ocular pressure‑lowering effect.
  • Anticholinergic medications: increased systemic anticholinergic load.
  • Topical corticosteroids: potential for heightened intra‑ocular pressure when combined.

Frequently Asked Questions

Mydriasert is an ophthalmic preparation containing phenylephrine hydrochloride and tropicamide. It is used to produce rapid pupil dilation (mydriasis) during diagnostic eye examinations, fundus photography, and pre‑operative ocular assessments, allowing clinicians to view the retina and other intra‑ocular structures clearly.

Phenylephrine hydrochloride is an alpha‑1 adrenergic receptor agonist. By stimulating these receptors on the radial iris dilator muscle, it causes the muscle to contract, pulling the iris outward and contributing to pupil enlargement when combined with tropicamide.

The appropriate dose of Mydriasert is determined by the prescribing eye care professional based on the specific examination needs and patient characteristics. The prescriber will select the number of drops and timing required for adequate mydriasis.

Safety data for Mydriasert in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician after evaluating the individual situation.

To order Mydriasert, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Mydriasert combines an alpha‑1 agonist (phenylephrine) with a muscarinic antagonist (tropicamide), offering rapid and sustained dilation. Compared with single‑agent drops such as tropicamide alone, the combination often achieves quicker onset and greater pupil size, which can be advantageous for time‑sensitive examinations.

Mydriasert should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct light. Keep the container tightly closed when not in use and discard any solution that appears discolored or contaminated.

Mydriasert is applied topically to the eye as an ophthalmic solution. The prescriber will instruct the patient on the number of drops per eye and the interval between applications, typically instilling the drops directly onto the conjunctival sac.

The most serious risks include acute angle‑closure glaucoma, severe allergic reactions such as anaphylaxis, and systemic hypertension. Patients should be monitored for signs of these conditions, and the medication should be discontinued immediately if they occur.

Mydriasert should not be used in patients with known hypersensitivity to phenylephrine, tropicamide, or any excipients, nor in individuals with narrow‑angle or uncontrolled glaucoma, severe cardiovascular disease, or those taking monoamine oxidase inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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