Product image of Mydriasert (Phenylephrine Hydrochloride, Tropicamide) supplied by GNH India

Mydriasert

Active Ingredient:
Phenylephrine Hydrochloride, Tropicamide
Origin:
EU

Mydriasert (Phenylephrine Hydrochloride, Tropicamide)

Phenylephrine Hydrochloride/Tropicamide, the active ingredient in Mydriasert, is a mydriatic agent presented as an ophthalmic solution for ocular use. It induces pupil dilation to facilitate ophthalmic examinations and intra‑ocular procedures in patients requiring a clear view of the interior eye. Mydriasert is manufactured for the EU market and complies with international quality standards.

GNH India supplies Mydriasert as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Thea

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Indications & Clinical Uses

Mydriasert, a combination of phenylephrine hydrochloride and tropicamide, is used in ophthalmology to achieve pharmacologic mydriasis.

  • Diagnostic eye examinations: provides pupil dilation for thorough fundus evaluation.
  • Intra‑ocular surgery: facilitates access during cataract extraction or retinal procedures.
  • Laser therapy: enables adequate pupil size for laser photocoagulation.
  • Glaucoma assessment: allows visualization of angle structures during gonioscopy.

How It Works

  • Phenylephrine hydrochloride acts as an alpha‑1 adrenergic agonist, stimulating the radial iris dilator muscle to contract and widen the pupil. Tropicamide blocks muscarinic receptors in the sphincter pupillae, preventing constriction and producing cycloplegia. The combined effect results in rapid and sustained mydriasis, improving ocular visualization for diagnostic and therapeutic procedures.

Side Effects

Mydriasert may cause a range of ocular and systemic reactions.

Common Side Effects

  • Transient ocular discomfort or stinging sensation.
  • Redness of the conjunctiva.
  • Mild headache.
  • Temporary blurred vision.
  • Light sensitivity (photophobia).

Serious or Rare Side Effects

  • Acute angle‑closure glaucoma.
  • Systemic hypertension or blood pressure spikes.
  • Cardiac arrhythmias.
  • Severe allergic reaction (anaphylaxis).
  • Persistent cycloplegia beyond the expected duration.

Precautions & Warnings

Prior to using Mydriasert, consider the following safety measures.

  • Assess intra‑ocular pressure: avoid in patients with narrow‑angle glaucoma.
  • Screen for cardiovascular disease: phenylephrine may elevate blood pressure.
  • Check for hypersensitivity: discontinue if allergic reactions occur.
  • Use with caution in children: safety data are limited.
  • Store at ambient temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Mydriasert can interact with other medications; monitor patients accordingly.

Major Interactions (Avoid)

  • MAO inhibitors: risk of hypertensive crisis due to additive vasoconstriction.
  • Tricyclic antidepressants: may increase systemic blood pressure effects.

Moderate Interactions (Monitor Closely):\n- Beta‑blockers: may blunt systemic cardiovascular responses.

  • Other mydriatic agents: can lead to excessive pupil dilation.
  • Anticholinergic drugs: may enhance cycloplegic effects.

Frequently Asked Questions

Mydriasert is an ophthalmic solution containing phenylephrine hydrochloride and tropicamide that is used to induce pupil dilation (mydriasis) for diagnostic eye examinations, intra‑ocular surgeries, and laser procedures. The drug provides a clear view of the interior structures of the eye, facilitating accurate assessment and treatment.

Phenylephrine hydrochloride is an alpha‑1 adrenergic agonist. It binds to alpha‑1 receptors on the radial iris dilator muscle, causing the muscle to contract. This contraction pulls the iris outward, widening the pupil and contributing to the overall mydriatic effect when combined with tropicamide.

The specific dosage and administration schedule for Mydriasert are determined by the prescribing eye care professional based on the patient’s condition, age, and the intended procedure. Clinicians select the appropriate number of drops and timing to achieve the desired level of pupil dilation.

Safety data for Mydriasert in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers should evaluate the individual situation and discuss possible alternatives when necessary.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Mydriasert. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Mydriasert combines phenylephrine, an alpha‑1 agonist, with tropicamide, a muscarinic antagonist, offering rapid and sustained dilation. Compared with single‑agent preparations, this combination often achieves a broader pupil size more quickly, reducing the need for multiple drops and improving procedural efficiency.

Mydriasert should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the solution from direct light and moisture to maintain stability. Do not freeze the product, and keep the container tightly closed when not in use.

Mydriasert is applied topically to the eye as a drop. The prescribing clinician determines the number of drops and timing, typically instilling the solution into the conjunctival sac of the target eye(s) a few minutes before the examination or procedure.

Serious risks include acute angle‑closure glaucoma, significant systemic hypertension, and rare cardiac arrhythmias. Patients with narrow‑angle glaucoma or uncontrolled cardiovascular disease should be evaluated carefully before use, and any signs of severe adverse reactions require immediate medical attention.

Mydriasert should be avoided in individuals with known hypersensitivity to phenylephrine, tropicamide, or any excipients in the formulation. It is also contraindicated in patients with narrow‑angle or acute angle‑closure glaucoma, and caution is advised for those with severe cardiovascular disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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