Product image of Myelomide (Lenalidomide) supplied by GNH India

Myelomide

Active Ingredient:
Lenalidomide
Origin:
EU

Myelomide (Lenalidomide)

Lenalidomide, the active ingredient in Myelomide, is an immunomodulatory drug presented as an oral tablet for oral use. It is indicated for the treatment of certain blood cancers, including multiple myeloma, mantle cell lymphoma, and myelodysplastic syndromes, in adult patients.

GNH India supplies Myelomide as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Anabiosis Pc

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Indications & Clinical Uses

  • Myelomide, an immunomodulatory agent, is employed in the management of specific hematologic malignancies.
  • Multiple myeloma: improves disease control and prolongs progression‑free survival in relapsed or refractory patients.
  • Mantle cell lymphoma: contributes to response rates when used in combination regimens.
  • Myelodysplastic syndromes: reduces transfusion dependence and delays transformation to acute leukemia.

How It Works

  • Lenalidomide binds to the cereblon component of the CRL4 E3 ubiquitin ligase complex, triggering ubiquitination and proteasomal degradation of transcription factors Ikaros and Aiolos. This leads to modulation of cytokine production, enhanced T‑cell and NK‑cell activity, anti‑angiogenic effects, and inhibition of malignant plasma‑cell proliferation.

Side Effects

Adverse reactions may occur with lenalidomide therapy and are categorized by frequency and severity.

Common Side Effects

  • Fatigue
  • Nausea
  • Diarrhea
  • Neutropenia
  • Rash
  • Constipation

Serious or Rare Side Effects

  • Thromboembolic events
  • Severe neutropenia or leukopenia
  • Secondary primary malignancies
  • Hepatic dysfunction
  • Severe cutaneous reactions (e.g., Stevens‑Johnson syndrome)
  • Embryo‑fetal toxicity (Category X).

Precautions & Warnings

  • Lenalidomide requires careful monitoring and patient counseling due to its risk profile.
  • Pregnancy: contraindicated; strict contraception required (Category X).
  • Thrombosis risk: assess history and consider prophylaxis.
  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Hematologic monitoring: perform regular complete blood counts.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture and light.

Avoid Interactions

Lenalidomide may interact with several drug classes, necessitating vigilance.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may increase lenalidomide exposure.
  • Anticoagulants: heightened risk of bleeding.
  • Live vaccines: increased risk of infection.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inducers: may reduce therapeutic levels.
  • Nephrotoxic agents: monitor renal function closely.
  • Immunosuppressants: watch for additive immunosuppression.

Frequently Asked Questions

Myelomide, containing lenalidomide, is prescribed for adult patients with multiple myeloma, mantle cell lymphoma, and myelodysplastic syndromes, often in relapsed or refractory settings.

Lenalidomide binds to cereblon, part of an E3 ubiquitin ligase complex, leading to degradation of transcription factors Ikaros and Aiolos. This modulates immune responses, inhibits angiogenesis, and reduces proliferation of malignant plasma cells.

The dosage of Myelomide is individualized; the prescribing physician determines the appropriate strength and schedule based on the patient’s condition, prior therapies, and clinical response.

Myelomide is classified as Pregnancy Category X and is contraindicated in pregnancy. Women of childbearing potential must use effective contraception, and breastfeeding is not recommended while on therapy.

To order Myelomide, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Compared with older agents such as thalidomide, lenalidomide offers improved potency and a more favorable side‑effect profile, particularly regarding neuropathy. It is often used in combination with dexamethasone or proteasome inhibitors, providing synergistic anti‑myeloma activity.

Myelomide tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep out of reach of children.

Myelomide is taken orally, usually once daily, with or without food, as directed by the treating physician. Swallow the tablet whole; do not crush or split unless instructed.

Serious risks include thromboembolic events, severe neutropenia or leukopenia, secondary malignancies, hepatic failure, severe skin reactions, and embryo‑fetal toxicity. Patients should be monitored closely for these events.

Myelomide is contraindicated in pregnant women, patients with known hypersensitivity to lenalidomide, and those with uncontrolled active infections. Caution is advised in patients with severe renal impairment or a history of thromboembolism.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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