Product image of Myfortic (Mycophenolic Acid) supplied by GNH India

Myfortic

Active Ingredient:
Mycophenolic Acid
Origin:
EU

Myfortic (Mycophenolic Acid)

Mycophenolic acid, the active ingredient in Myfortic, is an immunosuppressant presented as a delayed‑release tablet for oral use. It is indicated to prevent organ rejection in kidney and other solid organ transplant recipients, helping maintain graft function.

GNH India supplies Myfortic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide, providing quality‑assured products sourced from EU‑authorized manufacturers. The company adheres to stringent regulatory standards and offers reliable logistics for global markets, benefiting clients with transparent pricing, batch traceability, and dedicated technical support throughout the supply chain.

Manufacturer / TM Owner

Novartis Pharma S.A.S.

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Indications & Clinical Uses

  • Myfortic (mycophenolate sodium) is used in the immunosuppressive pathway to prevent graft rejection after solid organ transplantation.
  • Kidney transplant: prevents acute and chronic rejection, supporting long‑term graft survival.
  • Liver transplant: reduces risk of rejection and improves graft function.
  • Heart transplant: helps maintain graft tolerance and reduces incidence of rejection episodes.

How It Works

  • Mycophenolate sodium is a prodrug that is rapidly converted to mycophenolic acid, which selectively inhibits inosine monophosphate dehydrogenase (IMPDH). By blocking IMPDH, the drug curtails de novo guanosine nucleotide synthesis, a pathway essential for the proliferation of T and B lymphocytes, thereby dampening the immune response that leads to organ graft rejection.

Side Effects

Myfortic may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Gastrointestinal upset: nausea, vomiting, diarrhea, or abdominal pain.
  • Infections: increased susceptibility to bacterial, viral or fungal infections.
  • Hematologic changes: anemia, leukopenia, or thrombocytopenia.
  • Headache: mild to moderate intensity.

Serious or Rare Side Effects

  • Severe infection: opportunistic infections such as cytomegalovirus or Pneumocystis jirovecii pneumonia.
  • Neurotoxicity: seizures, encephalopathy, or posterior reversible encephalopathy syndrome.
  • Malignancy: increased risk of lymphoproliferative disorders or skin cancers.

Precautions & Warnings

When prescribing Myfortic, clinicians should consider several precautionary measures to minimize risk.

  • Renal function: adjust use in patients with impaired renal clearance.
  • Hepatic function: monitor liver enzymes as the prodrug is metabolized in the liver.
  • Infection risk: screen for latent infections and vaccinate before initiation.
  • Pregnancy: category D; avoid use unless benefits outweigh risks.
  • Contraception: advise women of child‑bearing potential to use effective contraception.
  • Store at ambient temperature: keep tablets below 25 °C in the original container, protected from moisture and light.

Avoid Interactions

Myfortic interacts with several medicines that can alter its exposure or increase toxicity.

Major Interactions (Avoid)

  • Antacids containing aluminum or magnesium: reduce absorption of mycophenolate; separate dosing by at least 2 hours.
  • Cyclosporine or tacrolimus: increase mycophenolate exposure and risk of hematologic toxicity.

Moderate Interactions (Monitor Closely)

  • Vaccines: live attenuated vaccines may cause infection; avoid during therapy.
  • Azathioprine: additive bone marrow suppression; monitor blood counts.
  • Contraceptive hormones: may reduce efficacy; consider alternative methods.

Frequently Asked Questions

Myfortic is a brand of mycophenolate sodium used as an immunosuppressant to prevent acute and chronic rejection of transplanted organs. It is prescribed for patients who have undergone kidney, liver, heart, or other solid organ transplants, helping maintain graft function and improve long‑term outcomes.

Mycophenolic acid, the active moiety of Myfortic, selectively inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH). This blockade reduces the synthesis of guanosine nucleotides, which are essential for the proliferation of T and B lymphocytes. By limiting lymphocyte expansion, the drug suppresses the immune response that can attack a transplanted organ.

The dose of Myfortic is individualized by the prescribing clinician based on factors such as the type of transplant, the patient’s renal and hepatic function, concomitant immunosuppressive therapy, and therapeutic drug monitoring results. No fixed regimen is provided here; the prescriber sets the appropriate dosage for each patient.

Myfortic is classified as Pregnancy Category D, indicating evidence of risk to the fetus. It should be avoided during pregnancy unless the potential benefit justifies the risk. Limited data are available for breastfeeding, and the drug may be excreted in milk; therefore, nursing mothers should discuss alternatives with their healthcare provider.

To order Myfortic, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including any cold‑chain requirements), and assists with import documentation.

Myfortic (mycophenolate sodium) and mycophenolate mofetil (CellCept) belong to the same antimetabolite class and share a similar mechanism of IMPDH inhibition. Myfortic is formulated as a delayed‑release tablet, which may improve gastrointestinal tolerability for some patients. Choice between the two often depends on physician preference, patient tolerance, and specific formulary considerations.

Myfortic tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original blister pack or container to protect from moisture and light. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Myfortic is taken orally as a delayed‑release tablet. The tablet should be swallowed whole with water and not crushed, chewed, or split, to preserve the controlled‑release properties. Dosing times are usually spaced evenly throughout the day as directed by the prescriber, often in combination with other immunosuppressants.

Serious risks include opportunistic infections such as cytomegalovirus or Pneumocystis jirovecii pneumonia, severe hematologic abnormalities like profound leukopenia or thrombocytopenia, neurotoxic events such as seizures or posterior reversible encephalopathy syndrome, and an increased long‑term risk of certain malignancies, particularly lymphoproliferative disorders and skin cancers.

Myfortic is contraindicated in patients with known hypersensitivity to mycophenolate sodium or any component of the formulation. It should also be avoided in individuals with severe, uncontrolled infections, active malignancy, or significant bone‑marrow suppression. Pregnant women should not use it unless the potential benefit outweighs the risk, and it is generally not recommended for breastfeeding mothers without specialist advice.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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