Product image of Myfortic (Mycophenolic Acid) supplied by GNH India

Myfortic

Active Ingredient:
Mycophenolic Acid
Origin:
EU

Myfortic (Mycophenolic Acid)

Mycophenolic acid, the active ingredient in Myfortic, is an immunosuppressant presented as a delayed‑release tablet for oral use. It is classified as an antimetabolite and is used to prevent organ rejection in patients who have undergone solid‑organ transplantation. Myfortic is marketed in the European Union and is supplied in tablet form for systemic administration.

GNH India supplies Myfortic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Manufacturer / TM Owner

Novartis Pharma Gmbh

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Indications & Clinical Uses

  • Myfortic is used to prevent graft rejection by modulating the immune response in solid‑organ transplantation.
  • Renal transplantation: reduces the incidence of acute and chronic rejection.
  • Heart transplantation: helps maintain graft function and lowers rejection episodes.
  • Liver transplantation: supports long‑term graft survival by suppressing immune activation.

How It Works

  • Myfortic (mycophenolate sodium) selectively inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme essential for de novo guanosine nucleotide synthesis. By limiting guanosine pools, the drug suppresses proliferation of T‑ and B‑lymphocytes, which rely on this pathway for clonal expansion, thereby providing targeted immunosuppression without broadly affecting other cell types.

Side Effects

Myfortic may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea or vomiting
  • Diarrhea or abdominal discomfort
  • Headache
  • Infections such as upper respiratory tract infections
  • Decreased white blood cell count (leukopenia)

Serious or Rare Side Effects

  • Severe neutropenia or agranulocytosis
  • Opportunistic infections (e.g., CMV, PCP)
  • Hepatic toxicity or elevated liver enzymes
  • Malignancies, including lymphoproliferative disorders
  • Life‑threatening allergic reactions (e.g., Stevens‑Johnson syndrome)

Precautions & Warnings

  • Before initiating Myfortic, clinicians should assess baseline laboratory values and consider patient‑specific risk factors.
  • Monitor blood counts regularly: watch for leukopenia or neutropenia.
  • Assess renal function: adjust dose in patients with impaired clearance.
  • Check liver enzymes: detect potential hepatic toxicity.
  • Avoid use in pregnancy: Myfortic is contraindicated (Category X).
  • Review concomitant medications: consider interactions that may increase toxicity.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture and light.

Avoid Interactions

Myfortic can interact with several drugs, requiring careful management.

Major Interactions (Avoid)

  • Azathioprine: additive bone‑marrow suppression.
  • Cyclosporine or tacrolimus: increased mycophenolate exposure.
  • Antacids containing aluminum or magnesium: reduce absorption of mycophenolate sodium.

Moderate Interactions (Monitor Closely)

  • Warfarin: may enhance anticoagulant effect, monitor INR.
  • Live vaccines: increased risk of infection, avoid administration.
  • NSAIDs: may exacerbate renal toxicity, monitor renal function.

Frequently Asked Questions

Myfortic is an oral immunosuppressant indicated to prevent rejection of transplanted organs, specifically in kidney, heart and liver transplantation. It works by dampening the immune response that can attack the transplanted tissue.

Mycophenolic acid, the active component of Myfortic, selectively inhibits the enzyme inosine monophosphate dehydrogenase (IMPDH). This blocks the synthesis of guanosine nucleot — a building block required for DNA replication in T‑ and B‑lymphocytes — thereby reducing their proliferation and suppressing immune‑mediated graft rejection.

The dosage of Myfortic is individualized by the prescribing physician based on the type of transplant, patient weight, renal function and concomitant immunosuppressants. Patients should follow the exact regimen provided by their healthcare professional.

Myfortic is classified as Pregnancy Category X, meaning it is contraindicated in pregnancy due to evidence of fetal harm. It is also not recommended while breastfeeding because the drug can be excreted in milk and may affect the infant.

To order Myfortic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Myfortic (mycophenolate sodium) is an antimetabolite that specifically targets lymphocyte proliferation, whereas calcineurin inhibitors such as cyclosporine act on T‑cell activation pathways. Myfortic is often combined with calcineurin inhibitors to achieve synergistic immunosuppression while offering a different side‑effect profile.

Myfortic tablets should be stored at ambient temperature below 25 °C. Keep them in the original blister pack, protect from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Myfortic is taken orally as a delayed‑release tablet, usually with food to improve tolerability. The tablet should be swallowed whole with a full glass of water and not crushed or chewed, as this could affect the controlled‑release properties.

Serious risks include severe neutropenia or agranulocytosis, opportunistic infections (e.g., cytomegalovirus, Pneumocystis jirovecii), hepatic toxicity, and rare but life‑threatening allergic reactions such as Stevens‑Johnson syndrome. Patients should be monitored closely for signs of infection or blood‑cell abnormalities.

Myfortic should not be used by individuals who are pregnant, have known hypersensitivity to mycophenolate sodium or any tablet excipients, or have uncontrolled severe infections. Caution is also advised in patients with significant renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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