Product image of Myfortic (Mycophenolic Acid) supplied by GNH India

Myfortic

Active Ingredient:
Mycophenolic Acid
Origin:
EU

Myfortic (Mycophenolic Acid)

Mycophenolic Acid, the active ingredient in Myfortic, is an immunosuppressant (antimetabolite) presented as a delayed‑release tablet for oral use. It helps prevent organ rejection in patients who have received kidney, heart or other solid organ transplants.

GNH India supplies Myfortic as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and pharmacies worldwide.

Manufacturer / TM Owner

Novartis Sverige Ab

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Indications & Clinical Uses

Myfortic is used to prevent rejection in solid‑organ transplantation by suppressing lymphocyte activity.

  • Renal transplantation: reduces the risk of acute and chronic graft rejection and supports long‑term graft survival.
  • Cardiac transplantation: lowers incidence of rejection episodes and helps maintain cardiac graft function.
  • Other solid organ transplants: maintains immunologic tolerance and decreases the likelihood of graft loss in liver, lung and pancreas transplants.

How It Works

  • Mycophenolic Acid selectively inhibits inosine monophosphate dehydrogenase (IMPDH), an enzyme essential for de novo guanosine nucleotide synthesis. By limiting guanosine availability, the drug suppresses proliferation of T‑ and B‑lymphocytes, which are critical mediators of the immune response that leads to organ graft rejection.

Side Effects

Myfortic may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: occasional upset stomach or feeling of queasiness.
  • Diarrhea: loose stools that may be mild to moderate.
  • Headache: transient cranial discomfort.
  • Tremor: fine shaking of hands or limbs.

Serious or Rare Side Effects

  • Leukopenia: significant reduction in white blood cells, increasing infection risk.
  • Severe infections: opportunistic or bacterial infections requiring medical attention.
  • Hepatic dysfunction: abnormal liver enzymes or hepatitis.
  • Malignancy: rare reports of post‑transplant lymphoproliferative disorder or other cancers.

Precautions & Warnings

Before initiating Myfortic, clinicians should consider several safety measures.

  • Monitor blood counts: perform regular complete blood count tests to detect leukopenia or anemia.
  • Assess renal function: check serum creatinine and glomerular filtration rate periodically.
  • Avoid live vaccines: live attenuated vaccines can cause infection in immunosuppressed patients.
  • Use contraception: pregnancy category D; effective contraception is required for women of childbearing potential.
  • Store below 25°C: keep in the original packaging, protect from moisture and excessive heat.

Avoid Interactions

Myfortic can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Cyclosporine: increases mycophenolic acid exposure, raising toxicity risk.
  • Rifampin: induces metabolism and reduces drug levels, compromising efficacy.
  • Antacids containing aluminum or magnesium: decrease absorption of mycophenolic acid.

Moderate Interactions (Monitor Closely)

  • Azathioprine: additive bone‑marrow suppression; monitor blood counts.
  • Valganciclovir: may enhance cytopenia; adjust dosing as needed.

Frequently Asked Questions

Myfortic contains mycophenolic acid and is prescribed to prevent rejection of transplanted organs such as kidneys, hearts, livers, lungs and pancreas. It works by suppressing the immune response that can damage the graft, helping maintain long‑term transplant function.

Mycophenolic acid blocks the enzyme inosine monophosphate dehydrogenase, which is needed for the synthesis of guanosine nucleotides. This inhibition limits the proliferation of T‑ and B‑lymphocytes, the immune cells responsible for attacking a transplanted organ, thereby reducing the likelihood of rejection.

The exact dose of Myfortic is individualized by the prescribing physician based on the type of transplant, patient weight, kidney function and other medications. Dosage adjustments are made according to therapeutic response and laboratory monitoring.

Myfortic is classified as pregnancy category D, indicating evidence of risk to the fetus. It should not be used during pregnancy unless the potential benefit justifies the risk. Limited data are available for breastfeeding; therefore, caution is advised and alternative therapy may be considered.

To request Myfortic, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Myfortic (mycophenolic acid) is an antimetabolite that specifically inhibits lymphocyte proliferation, whereas calcineurin inhibitors such as cyclosporine or tacrolimus act on T‑cell activation pathways. Myfortic is often used in combination with these agents to achieve synergistic immunosuppression while offering a different side‑effect profile.

Myfortic tablets should be stored at temperatures below 25 °C, in the original container to protect from moisture and light. Keep the medication out of reach of children and do not use if the packaging is damaged or the tablets appear discoloured.

Myfortic is taken orally as a delayed‑release tablet, usually twice daily, with food to improve tolerability. The tablet should be swallowed whole; it must not be crushed, chewed, or split, as this can alter the release characteristics and affect drug absorption.

Serious risks include severe infections due to immune suppression, leukopenia or anemia that can lead to bleeding or fatigue, liver toxicity, and rare cases of malignancy such as post‑transplant lymphoproliferative disorder. Patients should be monitored regularly for these complications.

Myfortic is contraindicated in patients with known hypersensitivity to mycophenolic acid or any tablet excipients. It should also be avoided in individuals with severe, uncontrolled infections, active malignancy, or those who are pregnant without a clear benefit outweighing fetal risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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