Product image of Mygdalon (Metoclopramide Hydrochloride Bp) supplied by GNH India

Mygdalon

Active Ingredient:
Metoclopramide Hydrochloride Bp
Origin:
EU

Mygdalon (Metoclopramide Hydrochloride Bp)

Metoclopramide Hydrochloride, the active ingredient in Mygdalon, is a dopamine antagonist presented as an oral formulation for oral use. It treats nausea and vomiting, gastroparesis, gastro‑oesophageal reflux disease and helps prevent chemotherapy‑induced nausea in adult patients.

GNH India supplies Mygdalon as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chelonia Healthcare Limited

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Indications & Clinical Uses

Metoclopramide is used to manage conditions that involve impaired gastrointestinal motility and nausea.

  • Nausea and vomiting: reduces episodes in postoperative, migraine and other acute settings.
  • Gastroparesis: improves gastric emptying and relieves related symptoms.
  • Gastro‑oesophageal reflux disease (GERD): decreases reflux episodes and associated discomfort.
  • Prevention of chemotherapy‑induced nausea: lowers incidence and severity of nausea during cancer treatment.

How It Works

  • Metoclopramide antagonizes peripheral and central D2 dopamine receptors while also blocking 5‑HT3 receptors. This dual action enhances gastrointestinal smooth‑muscle contractility, accelerates gastric emptying, and diminishes stimulation of the chemoreceptor trigger zone, thereby reducing nausea and vomiting.

Side Effects

Metoclopramide may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Drowsiness: feeling unusually sleepy or fatigued.
  • Restlessness: agitation or inability to stay still.
  • Diarrhea: loose or watery stools.
  • Dry mouth: reduced salivation leading to a dry feeling.

Serious or Rare Side Effects

  • Tardive dyskinesia: involuntary, repetitive movements, often of the face.
  • Neuroleptic malignant syndrome: high fever, muscle rigidity, autonomic instability.
  • Seizures: sudden, uncontrolled electrical activity in the brain.
  • Severe allergic reaction: rash, swelling, difficulty breathing.

Precautions & Warnings

Before prescribing Mygdalon, clinicians should consider several safety factors.

  • Renal or hepatic impairment: adjust use and monitor function.
  • Extrapyramidal symptoms: watch for muscle rigidity or tremor.
  • Depression or suicidal thoughts: use with caution.
  • Known hypersensitivity: avoid if allergic to metoclopramide.
  • Elderly patients: start at lower dose and monitor closely.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Metoclopramide can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Antipsychotics: increased risk of extrapyramidal effects.
  • CYP2D6 inhibitors: elevated metoclopramide plasma levels.
  • MAO inhibitors: potential hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Anticholinergics: may reduce pro‑kinetic efficacy.
  • SSRIs: risk of serotonin syndrome.
  • Alcohol: enhanced central nervous system depression.

Frequently Asked Questions

Mygdalon, containing metoclopramide hydrochloride, is prescribed to treat nausea and vomiting, manage gastroparesis, alleviate gastro‑oesophageal reflux disease symptoms, and prevent nausea associated with chemotherapy in adult patients.

Metoclopramide blocks dopamine D2 receptors in the brain and gut and also antagonizes 5‑HT3 receptors. This dual action speeds up gastric emptying, improves intestinal motility, and reduces stimulation of the brain’s vomiting center.

The specific dose of Mygdalon is determined by the prescribing clinician based on the patient’s condition, age, renal and hepatic function, and other individual factors. Patients should follow the prescriber’s instructions exactly.

Safety data for metoclopramide in pregnancy and lactation are limited. The prescriber should weigh potential benefits against possible risks before prescribing to pregnant or nursing women, and use only if clearly needed.

To request Mygdalon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other antiemetics such as ondansetron, Mygdalon offers both dopamine and serotonin blockade, providing a broader mechanism for nausea control and added pro‑kinetic benefits for gastric motility, though it may carry a higher risk of extrapyramidal side effects.

Mygdalon should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Do not store in extreme heat or humidity.

Mygdalon is taken orally, usually as a tablet, and should be swallowed with a glass of water. The exact timing relative to meals or other medications is determined by the prescriber.

Serious risks include tardive dyskinesia, neuroleptic malignant syndrome, severe allergic reactions, and seizures. Patients should be monitored for any unusual movements, fever, rigidity, or breathing difficulties and seek immediate medical attention if they occur.

Mygdalon is contraindicated in individuals with known hypersensitivity to metoclopramide or any component of the formulation, and should be avoided in patients with a history of severe extrapyramidal disorders, uncontrolled epilepsy, or certain cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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