Product image of Mykofungin 3 (Clotrimazole) supplied by GNH India

Mykofungin 3

Active Ingredient:
Clotrimazole
Origin:
EU

Mykofungin 3 (Clotrimazole)

Clotrimazole, the active ingredient in Mykofungin 3, is an azole antifungal presented as a vaginal formulation for local use. It treats vaginal candidiasis by targeting fungal growth in the affected area.

GNH India supplies Mykofungin 3 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mibe Gmbh Arzneimittel

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Indications & Clinical Uses

  • Mykofungin 3, a topical azole antifungal, is used to manage fungal infections of the vaginal mucosa.
  • Vulvovaginal candidiasis: reduces itching, discharge and irritation caused by Candida species.
  • Recurrent vaginal yeast infection: helps prevent recurrence when used as prescribed.
  • Topical antifungal therapy: provides local eradication of fungal over‑growth in the vaginal mucosa.

How It Works

  • Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts fungal cell‑membrane integrity, leading to increased permeability and ultimately fungal cell death.

Side Effects

Local application of Mykofungin 3 may cause mild, transient reactions.

Common Side Effects

  • Vaginal irritation or burning sensation.
  • Itching or mild discomfort.
  • Unpleasant vaginal discharge.
  • Local redness or swelling.
  • Mild odor change.
  • Slight spotting after insertion.

Serious or Rare Side Effects

  • Allergic reaction with rash or hives.
  • Severe skin eruption such as Stevens‑Johnson syndrome.
  • Vulvar edema or swelling.
  • Systemic hypersensitivity reactions.
  • Rare hepatotoxicity with systemic absorption.
  • Persistent severe irritation requiring medical attention.

Precautions & Warnings

  • Before using Mykofungin 3, consider the following safety measures.
  • Assess for hypersensitivity: avoid if known allergy to clotrimazole or other azoles.
  • Avoid use in severe hepatic impairment: limited systemic absorption but caution is advised.
  • Pregnancy considerations: consult a healthcare professional before use during pregnancy.
  • Limit duration of therapy: follow prescriber instructions to reduce resistance risk.
  • Store at ambient temperature below 25°C: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Clotrimazole may interact with other medicines; monitor as indicated.

Major Interactions (Avoid)

  • Concurrent systemic azoles: may increase systemic exposure.
  • Use with oral contraceptives: may reduce efficacy.
  • Co‑administration with hepatotoxic drugs: monitor liver function.

Moderate Interactions (Monitor Closely)

  • Topical irritants: may increase local irritation.
  • Other vaginal products (douches, spermicides): may affect absorption.
  • Simultaneous use of multiple topical antifungals: risk of resistance.

Frequently Asked Questions

Mykofungin 3 contains clotrimazole and is indicated for the treatment of vaginal candidiasis, a common yeast infection caused by Candida species. It is applied locally to relieve symptoms such as itching, discharge, and irritation.

Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, which is essential for ergosterol synthesis. Disruption of ergosterol production weakens the fungal cell membrane, leading to increased permeability and cell death, thereby clearing the infection.

The dosage regimen for Mykofungin 3 is determined by the prescribing healthcare professional based on the severity of infection and patient-specific factors. Patients should follow the prescriber’s instructions and not alter the dose on their own.

Safety data for clotrimazole in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Mykofungin 3.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Clotrimazole, the active ingredient in Mykofungin 3, belongs to the azole class and is widely used for topical treatment of vaginal yeast infections. Compared with polyene agents such as nystatin, azoles generally have a broader spectrum, better tolerability and convenient dosing, though choice depends on individual patient factors.

Store Mykofungin 3 at ambient temperature below 25 °C. Keep the product in its original packaging, protect it from moisture, heat and direct sunlight, and ensure the container is tightly closed to maintain stability.

Mykofungin 3 is applied intravaginally. The patient inserts the tablet or pessary into the vagina as directed by the prescriber, usually at bedtime, and follows the recommended duration of therapy to achieve optimal results.

Serious adverse reactions are rare but may include severe allergic responses such as rash, hives, or Stevens‑Johnson syndrome, as well as significant vulvar swelling. Any signs of a serious reaction require immediate medical attention.

Individuals with a known hypersensitivity to clotrimazole, other azole antifungals, or any component of the formulation should avoid using Mykofungin 3. Patients with severe liver disease should consult a healthcare professional before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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