Product image of Mykofungin 3 Kombi (Clotrimazole) supplied by GNH India

Mykofungin 3 Kombi

Active Ingredient:
Clotrimazole
Origin:
EU

Mykofungin 3 Kombi (Clotrimazole)

Clotrimazole, the active ingredient in Mykofungin 3 Kombi, is an azole antifungal presented as a topical formulation for cutaneous and vaginal use. It treats superficial candidiasis of the skin and mucous membranes in both adults and children.

GNH India supplies Mykofungin 3 Kombi as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mibe Gmbh Arzneimittel

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Indications & Clinical Uses

Mykofungin 3 Kombi, an azole antifungal, is employed to manage fungal infections of the skin and mucosa.

  • Cutaneous candidiasis: reduces fungal growth, relieving redness, itching and scaling.
  • Vaginal candidiasis: alleviates discharge, itching and irritation caused by yeast infection.
  • Intertriginous candidiasis: treats fungal infection in skin folds, improving comfort and preventing spread.

How It Works

  • Clotrimazole inhibits the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. By blocking ergosterol production, the drug disrupts the integrity of the fungal cell membrane, leading to increased permeability and ultimately cell death, thereby eliminating the infection.

Side Effects

Clotrimazole is generally well tolerated, but local reactions can occur.

Common Side Effects

  • Burning sensation at the application site.
  • Mild itching or redness.
  • Dryness or peeling of the skin.
  • Slight stinging when first applied.

Serious or Rare Side Effects

  • Severe allergic reaction (rash, swelling, difficulty breathing).
  • Contact dermatitis with extensive blistering.
  • Persistent irritation or ulceration of the mucosa.

Precautions & Warnings

Before using Mykofungin 3 Kombi, consider the following safety measures.

  • Avoid use on broken or inflamed skin: may increase irritation.
  • Do not use if you have a known allergy to clotrimazole or other azole antifungals.
  • Limit prolonged application: extended use can promote fungal resistance.
  • Consult a healthcare professional before use during pregnancy or breastfeeding.
  • Store at room temperature: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Clotrimazole may interact with other agents applied to the same area or systemic medications.

Major Interactions (Avoid)

  • Concurrent use of other topical azole products: may increase local irritation.
  • Application over areas treated with corticosteroid creams: can enhance skin thinning.

Moderate Interactions (Monitor Closely)

  • Use with systemic azole antifungals: may increase overall azole exposure.
  • Co‑administration with warfarin: monitor INR as a precaution, although topical exposure is minimal.

Frequently Asked Questions

Mykofungin 3 Kombi is used to treat superficial fungal infections such as cutaneous candidiasis, vaginal yeast infections, and intertriginous candidiasis. It works by applying the medication directly to the affected skin or mucosal area to eliminate the fungus and relieve symptoms.

Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, which is essential for producing ergosterol, a key component of fungal cell membranes. Without ergosterol, the membrane becomes compromised, leading to fungal cell death and resolution of the infection.

The dosage and duration of treatment are determined by the prescribing healthcare professional based on the type and severity of the infection. Patients should follow the specific instructions provided by their clinician or the product label.

Clotrimazole is generally considered low risk when used topically, but pregnant or breastfeeding individuals should consult their healthcare provider before starting treatment to ensure it is appropriate for their specific situation.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Mykofungin 3 Kombi contains clotrimazole, an azole antifungal that is widely used for its broad spectrum against Candida species. Compared with other topical agents such as miconazole or terbinafine, clotrimazole offers a well‑established safety profile and is available over the counter in many markets.

Store the product at room temperature, ideally below 25 °C. Keep it in the original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Apply a thin layer of the cream or ointment to the affected area once or twice daily, as directed by a healthcare professional. For vaginal use, insert the prescribed amount using an applicator or as instructed, typically for a short course of treatment.

The most serious risk is a severe allergic reaction, which may present as rash, swelling, or difficulty breathing. If any signs of anaphylaxis occur, seek immediate medical attention. Persistent irritation or ulceration at the application site should also be reported to a clinician.

Individuals with a known hypersensitivity to clotrimazole, other azole antifungals, or any component of the formulation should avoid using Mykofungin 3 Kombi. It is also not recommended for use on extensive broken skin without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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