Product image of Mykronor (Noradrenaline Tartrate) supplied by GNH India

Mykronor

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Mykronor (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Mykronor, is a sympathomimetic agent presented as an injectable solution for intravenous use. It is employed to raise blood pressure and improve cardiac output in patients with acute hypotension, septic shock, cardiogenic shock, or cardiac arrest when used as a vasopressor.

GNH India supplies Mykronor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

  • Mykronor is a vasopressor that acts on the sympathetic cardiovascular pathway to restore adequate perfusion in critical care settings.
  • Acute hypotension: raises systemic blood pressure to maintain organ perfusion.
  • Septic shock: counteracts vasodilatory shock by constricting peripheral vessels.
  • Cardiogenic shock: supports cardiac output while improving coronary perfusion.
  • Cardiac arrest: provides rapid vasoconstriction during resuscitation efforts.

How It Works

  • Noradrenaline tartrate stimulates alpha‑1 adrenergic receptors on vascular smooth muscle, producing peripheral vasoconstriction and increasing systemic vascular resistance. It also activates beta‑1 receptors in the heart, modestly enhancing myocardial contractility and heart rate, which together raise arterial pressure and improve tissue perfusion in shock states.

Side Effects

Mykronor may cause a range of adverse reactions that clinicians monitor during infusion.

Common Side Effects

  • Headache: transient and often related to rapid blood pressure changes.
  • Palpitations: due to beta‑1 stimulation of the heart.
  • Peripheral ischemia: reduced blood flow to extremities.
  • Nausea or vomiting: occasional gastrointestinal response.

Serious or Rare Side Effects

  • Cardiac arrhythmias: potentially life‑threatening rhythm disturbances.
  • Severe hypertension: excessive rise in blood pressure.
  • Tissue necrosis at infusion site: if extravasation occurs.
  • Myocardial ischemia: reduced oxygen supply to heart muscle.

Precautions & Warnings

Mykronor requires careful monitoring and specific safety measures before and during administration.

  • Dose titration: adjust infusion rate based on continuous blood pressure and cardiac monitoring.
  • Cardiac history: avoid rapid escalation in patients with known ischemic heart disease.
  • Extravasation risk: use a dedicated IV line and inspect the site frequently.
  • Drug compatibility: do not mix with solutions that may precipitate or inactivate the catecholamine.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Mykronor can interact with several agents that affect cardiovascular tone or catecholamine metabolism.

Major Interactions (Avoid)

  • Beta‑blockers: may blunt the intended increase in heart rate and contractility.
  • MAO inhibitors: can potentiate hypertensive responses.

Moderate Interactions (Monitor Closely)

  • Tricyclic antidepressants: may enhance vasoconstrictive effects.
  • Calcium channel blockers: can alter vascular response and require dose adjustments.
  • Diuretics: may affect intravascular volume and influence blood pressure targets.

Frequently Asked Questions

Mykronor is an injectable vasopressor containing noradrenaline tartrate. It is used in emergency and intensive‑care settings to raise blood pressure and improve cardiac output in patients experiencing acute hypotension, septic shock, cardiogenic shock, or cardiac arrest.

Noradrenaline tartrate acts as an agonist at alpha‑1 adrenergic receptors, causing peripheral vasoconstriction, and at beta‑1 receptors, modestly increasing heart rate and contractility. This dual action elevates systemic vascular resistance and cardiac output, helping restore adequate tissue perfusion during shock.

The dose of Mykronor is individualized by the treating physician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. Clinicians typically start with a low infusion rate and titrate upward while continuously monitoring vital signs.

Safety data for noradrenaline tartrate in pregnancy and lactation are limited. The product is generally reserved for life‑threatening situations where benefits outweigh potential risks, and its use should be decided by a qualified healthcare professional.

To order Mykronor, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Mykronor (noradrenaline) primarily provides potent alpha‑1 mediated vasoconstriction with modest beta‑1 activity, making it effective for severe hypotension. Dopamine has dose‑dependent effects, including renal vasodilation at low doses and stronger beta‑1 stimulation at moderate doses, but may cause more tachyarrhythmias. Choice depends on the clinical scenario and physician preference.

Mykronor must be stored refrigerated at 2‑8 °C, protected from light, and never frozen. The vial should be kept in its original packaging, and the solution should not be shaken. Prior to use, inspect for particulate matter and ensure the correct diluent is used according to the product label.

Mykronor is administered intravenously, usually via a dedicated infusion line. The drug is diluted in an appropriate compatible solution and infused under continuous hemodynamic monitoring. Dosage is titrated to achieve target blood pressure while observing for adverse effects.

Serious risks include severe hypertension, cardiac arrhythmias, myocardial ischemia, and tissue necrosis if the drug extravasates from the vein. These complications require immediate recognition and intervention, such as adjusting the infusion rate, providing anti‑arrhythmic therapy, or managing local tissue injury.

Mykronor is contraindicated in patients with known hypersensitivity to noradrenaline or any excipients in the formulation. Caution is advised in individuals with severe peripheral vascular disease, uncontrolled hypertension, or those receiving MAO inhibitors, as the drug may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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