Product image of Mykronor (Noradrenaline Tartrate) supplied by GNH India

Mykronor

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Mykronor (Noradrenaline Tartrate)

Noradrenaline tartrate, the active ingredient in Mykronor, is a sympathomimetic vasopressor presented as a sterile solution for injection for intravenous use. It is employed to raise blood pressure in acute hypotensive episodes, including septic, cardiogenic, and postoperative shock, under the supervision of qualified clinicians in hospital settings.

GNH India supplies Mykronor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide. The company adheres to EU GMP standards and provides cold‑chain logistics where required, ensuring product integrity from manufacture to end‑user.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

Mykronor, a sympathomimetic vasopressor, is used in conditions characterized by severe hypotension and circulatory shock.

  • Acute hypotension: restores systemic blood pressure to maintain organ perfusion.
  • Septic shock: supports vascular tone when endogenous catecholamines are insufficient.
  • Cardiogenic shock: augments cardiac output by increasing afterload and coronary perfusion pressure.
  • Post‑operative hypotension: stabilises hemodynamics during the immediate recovery period.

How It Works

  • Noradrenaline tartrate acts as a direct agonist at alpha‑1 adrenergic receptors, producing potent vasoconstriction that raises systemic vascular resistance. Simultaneous beta‑1 stimulation enhances myocardial contractility and heart rate, thereby increasing cardiac output. The combined alpha and beta effects rapidly elevate arterial pressure, counteracting the profound vasodilation seen in shock states.

Side Effects

Adverse reactions may occur with intravenous noradrenaline administration.

Common Side Effects

  • Tachycardia: increased heart rate due to beta‑1 stimulation.
  • Headache: result of rapid blood pressure elevation.
  • Anxiety or restlessness: central nervous system response to catecholamine surge.
  • Peripheral ischemia: reduced blood flow to extremities from intense vasoconstriction.

Serious or Rare Side Effects

  • Myocardial ischemia: excessive coronary vasoconstriction.
  • Severe hypertension: dangerously high arterial pressure.
  • Life‑threatening arrhythmias: ventricular tachycardia or fibrillation.
  • Tissue necrosis at the infusion site: extravasation of the vasopressor.

Precautions & Warnings

Careful monitoring and specific precautions are required when using Mykronor.

  • Dose titration: adjust infusion rate to achieve target mean arterial pressure.
  • Cardiovascular monitoring: continuous ECG and invasive blood pressure monitoring are essential.
  • Extravasation risk: inspect IV site frequently and avoid infiltration.
  • Contraindications: do not use in patients with known hypersensitivity to noradrenaline.
  • Pregnancy and lactation: administer only if potential benefits justify potential risks (category unknown).
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Noradrenaline may interact with several drug classes, requiring vigilance.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Tricyclic antidepressants: additive pressor effects.
  • Beta‑blockers: may blunt desired cardiac response.
  • General anesthetics that depress sympathetic tone: may reduce efficacy.
  • Potent vasodilators (e.g., nitroprusside): may counteract pressor action.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: may enhance hypotensive episodes when noradrenaline is tapered.
  • Calcium channel blockers: potential additive cardiovascular effects.
  • Diuretics: volume depletion can alter response.
  • Other vasopressors: overlapping mechanisms may increase risk of excessive vasoconstriction.
  • Sedatives and opioids: may mask signs of hypertension or tachycardia.

Frequently Asked Questions

Mykronor is an injectable formulation of noradrenaline tartrate used by clinicians to rapidly increase blood pressure in patients experiencing acute hypotension, septic shock, cardiogenic shock, or postoperative hypotension. It acts as a short‑acting pressor to stabilize hemodynamics during critical care.

Noradrenaline tartrate binds directly to alpha‑1 adrenergic receptors causing strong vasoconstriction, which raises systemic vascular resistance. It also stimulates beta‑1 receptors in the heart, enhancing contractility and heart rate, together producing a swift increase in arterial pressure.

The dosage of Mykronor is individualized. A qualified prescriber determines the infusion rate and titrates it based on the patient’s blood pressure response, clinical condition, and continuous monitoring. No fixed regimen is provided in public documentation.

The pregnancy category for noradrenaline tartrate is listed as unknown. It should only be used during pregnancy or lactation if the potential therapeutic benefit justifies any potential risk to the fetus or infant, and this decision must be made by the treating physician.

To request Mykronor, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Mykronor (noradrenaline) is considered a first‑line vasopressor for most shock states because of its balanced alpha‑1 and beta‑1 activity. Compared with dopamine, it provides more predictable vasoconstriction with less tachyarrhythmia risk, while epinephrine has stronger beta‑2 effects that can increase lactate levels.

Mykronor should be stored refrigerated at 2‑8 °C, protected from light, and must never be frozen or shaken. Before use, inspect the vial for particulate matter and ensure the solution is at room temperature if required for administration.

Mykronor is supplied as a sterile solution for injection and is administered intravenously, typically via a calibrated infusion pump. The infusion rate is titrated to achieve the desired blood pressure, with continuous hemodynamic monitoring throughout the treatment.

Serious risks include severe hypertension, myocardial ischemia, life‑threatening arrhythmias, and tissue necrosis from extravasation. Prompt recognition and management of these events are essential, and patients should be monitored continuously in an intensive care setting.

Mykronor is contraindicated in patients with known hypersensitivity to noradrenaline or any of its excipients. Caution is also advised in patients with severe peripheral vascular disease, uncontrolled hypertension, or those receiving MAO inhibitors, where the risk of adverse reactions may outweigh benefits.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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