Product image of Mykronor (Noradrenaline Tartrate) supplied by GNH India

Mykronor

Active Ingredient:
Noradrenaline Tartrate
Origin:
EU

Mykronor (Noradrenaline Tartrate)

Noradrenaline Tartrate, the active ingredient in Mykronor, is a vasopressor presented as an injection solution for intravenous use. It is employed to raise blood pressure in acute hypotensive states and to support circulation during various forms of shock.\n\nGNH India supplies Mykronor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoire Aguettant

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Indications & Clinical Uses

  • Mykronor acts on the sympathetic vascular pathway to restore perfusion in critical circulatory disorders.\n\nAcute hypotension: rapidly increases systemic vascular resistance to raise blood pressure.\nSeptic shock: supports hemodynamics when fluid resuscitation is insufficient.\nCardiogenic shock: augments cardiac output by improving coronary perfusion.\nCardiac arrest (adjunct): provides vasoconstriction to facilitate coronary and cerebral blood flow during resuscitation.\nAnaphylactic shock (when other agents insufficient): sustains vascular tone when antihistamines and epinephrine are inadequate.

How It Works

  • Noradrenaline Tartrate acts as a direct agonist at alpha‑adrenergic receptors, causing peripheral vasoconstriction and an increase in systemic vascular resistance. At higher plasma concentrations it also stimulates beta‑1 receptors, enhancing myocardial contractility and cardiac output, thereby improving arterial pressure and organ perfusion in shock states.

Side Effects

  • Adverse reactions may arise from excessive vasoconstriction or cardiac stimulation.\n\nCommon Side Effects:\n- Headache: due to rapid rise in blood pressure.\n- Tachycardia: secondary to beta‑1 stimulation.\n- Arrhythmia: ectopic beats or atrial fibrillation.\n- Peripheral ischemia: reduced blood flow to extremities.\n- Nausea: gastrointestinal upset.\n- Anxiety: heightened sympathetic activity.\n\nSerious or Rare Side Effects:\n- Myocardial ischemia: excessive coronary vasoconstriction.\n- Severe hypertension: risk of cerebrovascular events.\n- Tissue necrosis at infusion site: extravasation injury.\n- Life‑threatening arrhythmias: ventricular tachycardia/fibrillation.\n- Pulmonary edema: fluid overload with high cardiac output.

Precautions & Warnings

  • Careful monitoring is required when administering Mykronor to avoid complications.\n\nMonitor blood pressure: adjust infusion to maintain target MAP.\nAssess cardiac function: avoid in uncontrolled tachyarrhythmias.\nUse with caution in myocardial ischemia: risk of worsening ischemia.\nAvoid extravasation: ensure secure intravenous access.\nStore at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

  • Noradrenaline Tartrate can interact with several drug classes, altering its pressor effect or safety profile.\n\nMajor Interactions (Avoid):\n- Monoamine oxidase inhibitors: may precipitate hypertensive crisis.\n- Tricyclic antidepressants: additive vasoconstrictive effect.\n- Beta‑blockers: can blunt desired increase in cardiac output.\n\nModerate Interactions (Monitor Closely):\n- Calcium channel blockers: may enhance hypotensive episodes if noradrenaline is withdrawn.\n- Other vasopressors: risk of excessive vasoconstriction when combined.

Frequently Asked Questions

Mykronor is an injectable vasopressor containing noradrenaline tartrate. It is used in hospital settings to treat acute hypotension and various forms of shock, such as septic, cardiogenic, and anaphylactic shock, by rapidly increasing vascular tone and supporting blood pressure.

Noradrenaline acts as a direct agonist at alpha‑adrenergic receptors, causing peripheral blood vessels to constrict, which raises systemic vascular resistance. At higher concentrations it also stimulates beta‑1 receptors, enhancing heart contractility and cardiac output, together improving perfusion during shock.

The dose of Mykronor is individualized by the treating physician based on the patient’s hemodynamic status, target blood pressure, and response to therapy. Clinicians titrate the intravenous infusion to achieve the desired mean arterial pressure while monitoring for adverse effects.

Safety data for noradrenaline in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Mykronor, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and import documentation.

Mykronor (noradrenaline) is considered a first‑line vasopressor for most shock states because of its potent alpha‑adrenergic vasoconstriction and modest beta‑1 activity. Alternatives such as dopamine or phenylephrine may have different receptor profiles, but noradrenaline generally offers a more predictable increase in blood pressure with fewer tachyarrhythmic effects.

Mykronor should be stored at 2‑8 °C in a refrigerator. Keep the vial in its original packaging, protect it from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside this range.

Mykronor is supplied as an injectable solution for intravenous use only. It is typically administered via a controlled infusion pump, allowing precise titration of the dose to maintain target blood pressure while continuous hemodynamic monitoring is performed.

Serious risks include severe hypertension, myocardial ischemia, life‑threatening arrhythmias, and tissue necrosis if the drug extravasates from the vein. Continuous monitoring of blood pressure, cardiac rhythm, and infusion site is essential to detect and manage these complications promptly.

Mykronor is contraindicated in patients with known hypersensitivity to noradrenaline or any excipients, and it should be used with extreme caution in individuals with uncontrolled tachyarrhythmias, severe coronary artery disease, or peripheral vascular disease where excessive vasoconstriction could cause harm.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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