Product image of Myloxifin (Naloxone Hydrochloride, Oxycodone Hydrochloride) supplied by GNH India

Myloxifin

Active Ingredient:
Naloxone Hydrochloride, Oxycodone Hydrochloride
Origin:
EU

Myloxifin (Naloxone Hydrochloride, Oxycodone Hydrochloride)

Naloxone Hydrochloride and Oxycodone Hydrochloride, the active ingredients in Myloxifin, form a combination opioid analgesic and opioid antagonist presented as an oral tablet for the management of moderate to severe pain in adult patients requiring opioid therapy.

GNH India supplies Myloxifin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory conformity across global markets and providing reliable logistics for timely delivery.

Manufacturer / TM Owner

Ridge Pharma Limited

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Indications & Clinical Uses

  • Myloxifin, a combination of an opioid agonist and antagonist, is indicated for pain management within the opioid pathway.
  • Moderate to severe acute pain: provides effective analgesia while reducing the risk of opioid‑induced constipation and respiratory depression.
  • Chronic cancer‑related pain: maintains pain control with lower abuse potential.
  • Post‑operative pain: offers rapid onset analgesia with built‑in abuse deterrence.

How It Works

  • Oxycodone binds to mu‑opioid receptors in the central nervous system, activating them to produce analgesia. Naloxone, also a mu‑opioid receptor antagonist, is combined in a fixed ratio so that when taken orally it has limited systemic absorption, but it blocks opioid receptors if the formulation is tampered with or misused, thereby reducing opioid‑related adverse effects and abuse potential.

Side Effects

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Constipation: reduced bowel motility.
  • Dizziness: transient light‑headedness.
  • Headache: mild cranial discomfort.

Serious or Rare Side Effects

  • Respiratory depression: severe reduction in breathing rate.
  • Severe hypotension: marked drop in blood pressure.
  • Allergic reactions: rash, pruritus, or anaphylaxis.
  • Opioid withdrawal syndrome: symptoms if naloxone effect predominates.
  • Seizures: rare neurologic events.

Precautions & Warnings

  • Myloxifin should be prescribed with careful clinical assessment and monitoring.
  • Assess pain level: ensure opioid therapy is appropriate before prescribing.
  • Monitor for signs of opioid dependence: watch for cravings or misuse behaviors.
  • Evaluate renal and hepatic function: adjust if impairment present.
  • Avoid use in patients with known hypersensitivity to either component.
  • Store at ambient temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Myloxifin may interact with several medications; clinicians should review patient regimens.

Major Interactions (Avoid)

  • Concomitant use with other opioids: risk of additive respiratory depression.
  • MAO inhibitors: may precipitate severe hypertension or serotonin syndrome.
  • Benzodiazepines: increased sedation and respiratory risk.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole): may increase oxycodone levels.
  • CYP3A4 inducers (e.g., rifampin): may reduce efficacy.
  • Anticholinergic agents: may exacerbate constipation.

Frequently Asked Questions

Myloxifin is a prescription oral medication that combines an opioid analgesic with an antagonist to treat moderate to severe pain, such as acute postoperative pain, chronic cancer‑related pain, or other conditions where strong analgesia is required while minimizing abuse potential.

Oxycodone activates mu‑opioid receptors in the brain and spinal cord, producing analgesia. Naloxone, included in a fixed ratio, blocks those receptors if the tablet is altered or misused, limiting opioid‑related side effects and reducing the likelihood of dependence while still allowing normal pain relief when taken as directed.

The dosage of Myloxifin is individualized by the prescribing clinician based on the patient’s pain severity, prior opioid exposure, and overall health status. Only a qualified healthcare professional should determine the appropriate dose and dosing schedule.

Safety data for Myloxifin in pregnancy and lactation are limited. The potential risks and benefits should be evaluated by a healthcare provider, and the medication should only be used if clearly needed and after a thorough risk assessment.

To request Myloxifin, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Standard oxycodone tablets contain only the opioid agonist, which can carry a higher risk of misuse and opioid‑related side effects. Myloxifin adds naloxone, an antagonist that reduces these risks by limiting abuse potential and certain adverse effects, while still delivering comparable analgesic efficacy when used as prescribed.

Myloxifin should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the tablets from moisture, excessive heat, and direct sunlight to maintain potency and stability.

Myloxifin is taken orally, usually with a full glass of water. It may be administered with or without food, but patients should follow the specific instructions provided by their prescriber to ensure consistent absorption.

Serious risks include respiratory depression, severe hypotension, allergic reactions such as anaphylaxis, and opioid withdrawal symptoms if naloxone’s antagonistic effect predominates. Patients should be monitored closely for these events, especially during initiation or dose changes.

Myloxifin is contraindicated in individuals with known hypersensitivity to naloxone, oxycodone, or any excipients in the formulation, as well as in patients who have taken monoamine oxidase inhibitors within the past 14 days. It should also be avoided in patients with severe respiratory insufficiency or uncontrolled asthma.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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