Product image of Myobloc (Diacerein) supplied by GNH India

Myobloc

Active Ingredient:
Diacerein
Origin:
EU

Myobloc (Diacerein)

Diacerein, the active ingredient in Myobloc, is a disease-modifying osteoarthritis drug (DMOAD) presented as an oral formulation for oral use. It is indicated for the management of osteoarthritis of the knee and hip, providing symptomatic relief and slowing cartilage degradation in adult patients.

GNH India supplies Myobloc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Genepharm S.A.

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Indications & Clinical Uses

Myobloc is a disease‑modifying osteoarthritis drug that targets joint degeneration pathways.

  • Osteoarthritis of knee: reduces pain and slows cartilage loss, improving joint function.
  • Osteoarthritis of hip: alleviates discomfort and helps preserve joint structure.
  • General osteoarthritis: provides symptomatic relief and may delay disease progression.

How It Works

  • Diacerein inhibits interleukin‑1 (IL‑1) activity by blocking its binding to receptors, thereby reducing the synthesis of cartilage‑degrading enzymes and inflammatory mediators. This action helps preserve cartilage integrity and diminishes joint inflammation, contributing to symptom improvement in osteoarthritis.

Side Effects

Adverse reactions may occur with oral diacerein therapy.

Common Side Effects

  • Diarrhoea: loose stools occurring during early treatment.
  • Abdominal pain: discomfort or cramping in the stomach region.
  • Nausea: feeling of queasiness or urge to vomit.
  • Flatulence: excess intestinal gas.
  • Dyspepsia: indigestion or upper abdominal fullness.
  • Constipation: reduced bowel movements.

Serious or Rare Side Effects

  • Elevated liver enzymes: indicating possible hepatic stress.
  • Severe allergic reaction: rash, swelling, or difficulty breathing.
  • Stevens‑Johnson syndrome: rare skin blistering condition.
  • Blood dyscrasias: abnormal blood cell counts.
  • Severe skin rash: extensive erythema or exfoliation.

Precautions & Warnings

Patients should be monitored for safety considerations before and during therapy.

  • Liver function monitoring: check transaminases periodically.
  • Gastrointestinal caution: avoid in active ulcer disease.
  • Elderly use: start with lower dose and observe tolerance.
  • Renal impairment: adjust dose if kidney function is reduced.
  • Hypersensitivity: discontinue if allergic signs appear.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Diacerein may interact with other medicines, requiring attention to co‑administration.

Major Interactions (Avoid)

  • NSAIDs: combined use increases risk of gastrointestinal bleeding.
  • Anticoagulants: may potentiate bleeding tendencies.

Moderate Interactions (Monitor Closely)

  • CYP450 inducers (e.g., rifampicin): may reduce diacerein exposure.
  • Diuretics: monitor electrolyte balance.
  • Other DMOADs: assess additive effects on liver function.
  • Antacids: may affect absorption if taken simultaneously.

Frequently Asked Questions

Myobloc contains diacerein and is used to treat osteoarthritis of the knee and hip. It works by reducing inflammation and slowing cartilage breakdown, helping to relieve pain and improve joint function in adult patients with these conditions.

Diacerein blocks the activity of interleukin‑1, a cytokine that promotes inflammation and cartilage degradation. By inhibiting this pathway, the drug reduces the production of enzymes that damage joint cartilage, thereby decreasing pain and slowing disease progression.

The dosage of Myobloc is determined by the prescribing clinician based on the patient’s condition, age, and overall health. Healthcare professionals set the appropriate dose and schedule according to current clinical guidelines.

Safety data for diacerein in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Myobloc product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Unlike conventional NSAIDs that mainly provide pain relief, Myobloc (diacerein) is a disease‑modifying osteoarthritis drug that targets inflammatory pathways and cartilage degradation. This mechanism may offer longer‑term joint protection, though safety profiles differ and treatment choice should be individualized.

Myobloc should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture. Keep the product away from direct sunlight and out of reach of children to maintain its stability and efficacy.

Myobloc is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious risks include liver enzyme elevation, severe allergic reactions such as Stevens‑Johnson syndrome, and rare blood disorders. Patients should be monitored for signs of hepatic dysfunction, skin reactions, or abnormal blood counts and seek medical attention promptly if they occur.

Myobloc is contraindicated in individuals with known hypersensitivity to diacerein or any of its excipients, active gastrointestinal ulcer disease, and patients with severe liver impairment. Clinicians should evaluate each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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