Product image of Myocard (Doxazosin) supplied by GNH India

Myocard

Active Ingredient:
Doxazosin
Origin:
EU

Myocard (Doxazosin)

Doxazosin, the active ingredient in Myocard, is a Alpha-1 adrenergic antagonist presented as a tablet for oral use. It treats hypertension and benign prostatic hyperplasia in adults.

GNH India supplies Myocard as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Doxazosin acts on the alpha‑1 adrenergic pathway to lower vascular tone and relax smooth muscle in the prostate.

  • Hypertension: reduces peripheral vascular resistance, helping to lower systolic and diastolic blood pressure.
  • Benign prostatic hyperplasia: relaxes prostatic and bladder‑neck smooth muscle, improving urinary flow and reducing urgency.

How It Works

  • Doxazosin selectively and reversibly blocks alpha‑1 adrenergic receptors on vascular smooth muscle and in the prostate. This inhibition prevents norepinephrine‑mediated vasoconstriction, producing vasodilation and decreased peripheral resistance, while also relaxing smooth muscle in the lower urinary tract, facilitating urine passage.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Fatigue or tiredness
  • Nasal congestion
  • Peripheral edema
  • Nausea or upset stomach

Serious or Rare Side Effects

  • Marked hypotension, especially after the first dose
  • Syncope or fainting episodes
  • Worsening of heart failure symptoms
  • Severe hepatic dysfunction
  • Anaphylactic or severe allergic reactions
  • Priapism (prolonged erection)

Precautions & Warnings

Before initiating therapy, clinicians should assess individual risk factors and monitor patients regularly.

  • Blood pressure monitoring: check sitting and standing readings after dose adjustments.
  • Renal and hepatic function: evaluate baseline labs and adjust if impairment is present.
  • Orthostatic hypotension: advise patients to rise slowly from sitting or lying positions.
  • Concomitant antihypertensives: consider dose reduction to avoid excessive blood pressure fall.
  • Discontinuation: taper gradually rather than stopping abruptly to prevent rebound hypertension.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Doxazosin may interact with several drug classes, requiring clinical vigilance.

Major Interactions (Avoid)

  • Other alpha‑1 blockers (e.g., prazosin, terazosin) – additive hypotensive effect.
  • Potent CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) – increased plasma concentrations.
  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil) – risk of severe hypotension.

Moderate Interactions (Monitor Closely)

  • Diuretics – may enhance orthostatic blood pressure drop.
  • Beta‑blockers – combined effect on heart rate and blood pressure.
  • NSAIDs – may blunt antihypertensive response.
  • ACE inhibitors or ARBs – additive blood pressure lowering.
  • Lithium – possible increase in lithium levels.

Frequently Asked Questions

Myocard contains doxazosin, which is prescribed to manage high blood pressure (hypertension) and to relieve urinary symptoms associated with benign prostatic hyperplasia (BPH). By lowering vascular resistance and relaxing prostate smooth muscle, the medication helps control blood pressure and improve urine flow in adult patients.

Doxazosin selectively blocks alpha‑1 adrenergic receptors on blood vessels and in the prostate. This blockade prevents norepinephrine‑induced vasoconstriction, leading to vessel dilation and reduced peripheral resistance, while also relaxing smooth muscle in the prostate and bladder neck, facilitating easier urination.

The dosage of Myocard is individualized by a qualified prescriber based on the patient’s medical condition, response, and tolerability. Physicians determine the appropriate starting dose and any subsequent adjustments, following clinical guidelines and patient monitoring.

Safety data for doxazosin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To request Myocard, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Compared with non‑selective alpha blockers, doxazosin offers a more targeted alpha‑1 blockade, resulting in fewer reflex tachycardia events. Relative to calcium‑channel blockers or ACE inhibitors, its primary benefit is concurrent treatment of BPH, making it a convenient option for patients needing both blood‑pressure control and urinary symptom relief.

Store Myocard tablets at temperatures below 25 °C (77 °F). Keep the product in its original container, protect it from moisture and direct sunlight, and ensure the packaging remains tightly closed until use.

Myocard is taken orally, usually once daily with or without food, as directed by the prescribing clinician. Patients should swallow the tablet whole with a full glass of water and follow any specific timing instructions provided by their healthcare professional.

Serious adverse events can include severe hypotension, syncope, worsening heart‑failure symptoms, and rare cases of liver injury or severe allergic reactions. Patients should seek immediate medical attention if they experience fainting, rapid weight gain, jaundice, or signs of anaphylaxis.

Myocard is contraindicated in patients with known hypersensitivity to doxazosin or any component of the formulation, and in those with severe hypotension or cardiogenic shock. Caution is also advised for individuals with significant liver disease, renal impairment, or a history of orthostatic dizziness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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