Product image of Myocet Liposomal (Doxorubicin Hydrochloride) supplied by GNH India

Myocet Liposomal

Active Ingredient:
Doxorubicin Hydrochloride
Origin:
EU

Myocet Liposomal (Doxorubicin Hydrochloride)

Doxorubicin Hydrochloride, the active ingredient in Myocet Liposomal, is an anthracycline antibiotic presented as a liposomal injection for intravenous use. It is employed in the treatment of metastatic breast cancer, ovarian cancer and multiple myeloma in adult patients.

GNH India supplies Myocet Liposomal as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres, hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides cold‑chain logistics for injectable products. Customers benefit from reliable delivery, regulatory support and comprehensive product documentation.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

  • Myocet Liposomal (doxorubicin hydrochloride) is used in the treatment of solid tumours and hematologic malignancies that respond to anthracycline‑based chemotherapy.
  • Metastatic breast cancer: improves disease control and overall survival in adult patients.
  • Ovarian cancer: used in combination regimens for recurrent or refractory disease.
  • Multiple myeloma: employed in relapsed or refractory settings as part of combination therapy.

How It Works

  • Doxorubicin intercalates between DNA base pairs, blocking the progression of topoisomerase II during replication and transcription. This inhibition prevents the resealing of DNA strands, leading to double‑strand breaks. In addition, the drug generates free radicals that cause oxidative damage to cellular membranes and organelles, ultimately inducing apoptosis of rapidly dividing tumour cells. The liposomal encapsulation enhances delivery to tumour tissue while reducing exposure to healthy cells.

Side Effects

Myocet Liposomal may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Nausea and vomiting
  • Fatigue
  • Alopecia (hair loss)
  • Myelosuppression (decreased blood cell counts)

Serious or Rare Side Effects

  • Cardiotoxicity (heart failure, reduced ejection fraction)
  • Severe neutropenia or febrile neutropenia
  • Secondary acute myeloid leukemia
  • Severe infusion‑related reactions (hypotension, bronchospasm)

Precautions & Warnings

  • Before initiating Myocet Liposomal therapy, clinicians should consider several precautionary measures to minimise risk.
  • Cardiac monitoring: baseline and periodic echocardiograms to detect early cardiotoxicity.
  • Hematologic monitoring: complete blood counts before each infusion to assess myelosuppression.
  • Renal and hepatic function: evaluate organ function as impairment may affect drug clearance.
  • Pregnancy and lactation: avoid use unless benefits clearly outweigh potential fetal or neonatal risks.
  • Concomitant cardiotoxic agents: review and limit use of other drugs that may increase cardiac injury.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Myocet Liposomal can interact with other medicines, influencing efficacy or toxicity.

Major Interactions (Avoid)

  • Concurrent anthracyclines: additive cardiotoxicity risk.
  • Combination with trastuzumab: heightened cardiac dysfunction.
  • Live vaccines: increased risk of infection due to immunosuppression.

Moderate Interactions (Monitor Closely)

  • Cyclophosphamide: may increase myelosuppression.
  • Antifungal azoles (e.g., fluconazole): can alter doxorubicin metabolism.
  • Granulocyte colony‑stimulating factor (G‑CSF): may affect neutrophil recovery timing.

Frequently Asked Questions

Myocet Liposomal is a liposomal formulation of doxorubicin hydrochloride indicated for the treatment of metastatic breast cancer, ovarian cancer and multiple myeloma. It is used in adult patients when anthracycline‑based chemotherapy is appropriate, often as part of combination regimens to improve tumour control.

Doxorubicin intercalates into DNA, inhibiting topoisomerase II and preventing the resealing of DNA strands during replication. This creates double‑strand breaks and triggers oxidative stress through free‑radical generation, leading to apoptosis of rapidly dividing cancer cells. The liposomal carrier helps concentrate the drug in tumour tissue.

The prescribed dose of Myocet Liposomal is determined by the treating physician based on factors such as the patient’s body surface area, disease stage, prior therapies, organ function and overall clinical condition. Dosing is individualized and adjusted according to response and tolerability.

Safety data for Myocet Liposomal in pregnancy and lactation are limited, and the drug may cause fetal harm. It is generally contraindicated during pregnancy and breastfeeding unless the potential benefit justifies the risk. Women of child‑bearing potential should use effective contraception during treatment.

To order Myocet Liposomal, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Myocet Liposomal encapsulates doxorubicin in liposomes, which can reduce exposure of healthy tissues and lower the incidence of certain side effects, especially cardiotoxicity, compared with conventional free‑form doxorubicin. Efficacy in approved indications is comparable, while the liposomal formulation may offer a more favourable safety profile for some patients.

Myocet Liposomal must be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking the product. Do not store at room temperature for prolonged periods, as stability may be compromised.

Myocet Liposomal is given as an intravenous infusion by a qualified healthcare professional. The infusion rate and duration are determined by the prescribing physician and may be adjusted based on patient tolerance and clinical response. It is typically administered in a clinical setting with appropriate monitoring.

The most serious risks include cardiotoxicity (which can lead to heart failure), severe neutropenia or febrile neutropenia, secondary acute myeloid leukemia, and severe infusion‑related reactions such as hypotension or bronchospasm. Regular cardiac and hematologic monitoring is essential to detect these complications early.

Myocet Liposomal should be avoided in patients with known hypersensitivity to doxorubicin or any liposomal components, those with uncontrolled cardiac disease, severe hepatic impairment, or active infections that could be worsened by immunosuppression. It is also contraindicated during pregnancy and lactation unless the benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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