Product image of Myocet Liposomal (Doxorubicin Hydrochloride) supplied by GNH India

Myocet Liposomal

Active Ingredient:
Doxorubicin Hydrochloride
Origin:
EU

Myocet Liposomal (Doxorubicin Hydrochloride)

Doxorubicin Hydrochloride, the active ingredient in Myocet Liposomal, is an anthracycline antibiotic presented as a liposomal injection for intravenous use. It is employed in the treatment of certain advanced solid tumours, notably metastatic breast cancer and ovarian cancer.

GNH India supplies Myocet Liposomal as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Cheplapharm Arzneimittel Gmbh

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Indications & Clinical Uses

Myocet Liposomal, an anthracycline used in oncology, is indicated for the following conditions:

  • Metastatic breast cancer: improves disease control in patients with advanced disease.
  • Ovarian cancer: used in combination regimens for recurrent or refractory disease.

How It Works

  • Doxorubicin Hydrochloride intercalates between DNA base pairs and inhibits topoisomerase II, preventing DNA replication and transcription. The liposomal formulation enhances delivery to tumour cells while reducing systemic exposure, and the drug also generates free radicals that cause additional cytotoxic damage to malignant cells.

Side Effects

Myocet Liposomal may cause a range of adverse reactions.

Common Side Effects

  • Nausea and vomiting: frequent gastrointestinal upset.
  • Alopecia: reversible hair loss.
  • Fatigue: generalised tiredness.
  • Myelosuppression: reduced blood cell counts.
  • Mucositis: inflammation of the mouth lining.

Serious or Rare Side Effects

  • Cardiotoxicity: potential for reduced heart function.
  • Severe neutropenia: heightened infection risk.
  • Thrombocytopenia: increased bleeding tendency.
  • Secondary leukemia: rare but serious long‑term risk.
  • Pulmonary toxicity: rare lung inflammation.

Precautions & Warnings

Before initiating therapy, several safety considerations are recommended.

  • Cardiac monitoring: baseline and periodic assessment of left ventricular ejection fraction.
  • Dose adjustments: modify dosing in renal or hepatic impairment as advised.
  • Avoid concurrent cardiotoxic agents: limit use with other anthracyclines or trastuzumab.
  • Monitor blood counts: regular complete blood count to detect myelosuppression.
  • Pregnancy and lactation: contraindicated unless benefits outweigh potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Myocet Liposomal can interact with several other medicines.

Major Interactions (Avoid)

  • Concurrent anthracyclines: additive cardiotoxicity.
  • Trastuzumab co‑administration: heightened risk of cardiac dysfunction.

Moderate Interactions (Monitor Closely)

  • CYP450 inhibitors: may increase plasma concentrations of doxorubicin.
  • Radiation therapy: potential for enhanced tissue damage.
  • Anticoagulants: increased bleeding tendency.

Frequently Asked Questions

Myocet Liposomal is a liposomal formulation of doxorubicin hydrochloride indicated for the treatment of metastatic breast cancer and ovarian cancer. It is administered intravenously as part of a chemotherapy regimen to target malignant cells.

Doxorubicin hydrochloride intercalates into DNA and blocks topoisomerase II, halting DNA replication and transcription. The drug also generates free radicals that damage cellular components, leading to tumour cell death.

The specific dose of Myocet Liposomal is determined by the prescribing oncologist based on the patient’s clinical condition, body surface area, and treatment protocol. Dosage regimens are individualized and should follow local prescribing guidelines.

Myocet Liposomal is generally contraindicated in pregnancy and lactation because of potential fetal and infant toxicity. It should only be used if the potential benefit justifies the risk, and women of child‑bearing potential should use effective contraception.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Myocet Liposomal encapsulates doxorubicin in liposomes, which can reduce peak plasma concentrations and limit exposure to healthy tissues. This formulation often results in a lower incidence of certain toxicities, such as cardiotoxicity, while maintaining comparable antitumour efficacy to conventional doxorubicin.

Myocet Liposomal should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Prior to administration, the product should be inspected for particulate matter and used within the time frame recommended by the manufacturer.

Myocet Liposomal is given as an intravenous infusion, typically diluted in an appropriate compatible solution and administered over a prescribed period. Administration should be performed by qualified healthcare professionals in a setting equipped for infusion therapy and monitoring.

The most serious risks include cardiotoxicity, which can lead to irreversible heart failure, severe neutropenia increasing infection risk, and rare events such as secondary leukemia. Patients should be closely monitored for cardiac function and blood counts throughout treatment.

Myocet Liposomal is contraindicated in patients with known hypersensitivity to doxorubicin or any component of the formulation, in those with pre‑existing severe cardiac disease, and in pregnant or breastfeeding women unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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