Product image of Myoview (Tetrofosmin) supplied by GNH India

Myoview

Active Ingredient:
Tetrofosmin
Origin:
EU

Myoview (Tetrofosmin)

Tetrofosmin, the active ingredient in Myoview, is a radiopharmaceutical presented as a sterile solution for injection for intravenous use. It is used to assess myocardial perfusion and viability in patients undergoing cardiac imaging.

GNH India supplies Myoview as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ge Healthcare As

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Indications & Clinical Uses

  • Myoview is employed in cardiac imaging to evaluate myocardial blood flow and detect coronary artery disease.
  • Myocardial perfusion imaging (stress and rest): provides quantitative assessment of myocardial perfusion during stress and rest conditions.
  • Coronary artery disease detection: helps identify obstructive coronary lesions by highlighting perfusion defects.
  • Myocardial viability assessment: distinguishes viable myocardium from scar tissue to guide revascularisation decisions.

How It Works

  • Tetrofosmin is a lipophilic cationic complex that readily crosses cell membranes and is taken up by myocardial cells in proportion to regional blood flow. Viable myocardial tissue retains the tracer, allowing single‑photon emission computed tomography (SPECT) cameras to generate high‑resolution images of perfusion distribution across the heart.

Side Effects

Adverse reactions may occur following intravenous administration of Myoview.

Common Side Effects

  • Nausea or vomiting
  • Transient flushing or warmth sensation
  • Headache or dizziness
  • Mild hypotension
  • Injection site pain or erythema

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction
  • Marked hypotension or cardiovascular collapse
  • Life‑threatening arrhythmias
  • Respiratory distress or bronchospasm
  • Severe chest pain indicative of myocardial ischemia

Precautions & Warnings

  • Myoview should be used with appropriate clinical assessment and adherence to radiation safety guidelines.
  • Patient assessment: evaluate cardiac stability and ability to tolerate SPECT imaging.
  • Hypersensitivity: avoid in individuals with known allergy to tetrofosmin or formulation excipients.
  • Pregnancy and lactation: use only if diagnostic benefit outweighs potential fetal or infant radiation risk.
  • Renal or hepatic impairment: consider altered tracer clearance and adjust imaging protocol if needed.
  • Concurrent cardiac drugs: be aware that vasodilators or beta‑blockers may affect myocardial uptake.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake the vial.

Avoid Interactions

Tetrofosmin may interact with other agents that influence myocardial blood flow or radiotracer distribution.

Major Interactions (Avoid)

  • Concurrent administration of other myocardial perfusion radiopharmaceuticals (e.g., technetium‑99m sestamibi) within the same imaging session.
  • High‑dose vasodilators that markedly alter coronary flow during the uptake phase.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers or calcium channel blockers that modify heart rate and perfusion patterns.
  • Drugs affecting thyroid function, as they may influence radiotracer kinetics.
  • Contrast agents used in CT that could interfere with subsequent SPECT imaging.

Frequently Asked Questions

Myoview is a radiopharmaceutical containing tetrofosmin that is used in nuclear medicine to visualize myocardial perfusion during stress and rest SPECT imaging. It helps clinicians detect coronary artery disease and assess the viability of heart muscle tissue.

Tetrofosmin is a lipophilic cation that readily crosses cell membranes and accumulates in myocardial cells in proportion to regional blood flow. Viable heart cells retain the tracer, allowing a SPECT camera to produce detailed images of perfusion distribution across the myocardium.

The administered dose of Myoview is determined by the prescribing physician or nuclear cardiology protocol, based on patient weight, imaging equipment, and clinical indication. Exact dosing is individualized and not standardized in publicly available literature.

Safety data for tetrofosmin in pregnant or lactating women are limited. The agent is generally used only when the diagnostic benefit outweighs potential radiation risk to the fetus, and breastfeeding is usually discouraged until the tracer has been cleared from the body.

To request Myoview, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and the necessary import documentation.

The primary alternative to tetrofosmin is technetium‑99m sestamibi. Both agents provide myocardial perfusion imaging, but tetrofosmin has a slightly higher first‑pass extraction and may yield clearer images in certain stress protocols, whereas sestamibi is more widely available in some regions.

Myoview must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Keep the vial in its original packaging until use and inspect for particulate matter before administration.

Myoview is supplied as a sterile solution for intravenous injection. The tracer is injected as a rapid bolus through a peripheral vein, followed by a waiting period that allows myocardial uptake before SPECT image acquisition begins.

Serious adverse reactions, although rare, can include severe allergic responses such as anaphylaxis, marked hypotension, or life‑threatening arrhythmias. Any signs of respiratory distress, rapid heart‑rate changes, or skin reactions after injection should prompt immediate medical evaluation.

Myoview is contraindicated in patients with known hypersensitivity to tetrofosmin or any component of the formulation. It should also be avoided in individuals with unstable cardiac conditions, severe asthma, or those unable to undergo SPECT imaging because they cannot remain still for the required duration.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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