Product image of Myoview (Tetrofosmin) supplied by GNH India

Myoview

Active Ingredient:
Tetrofosmin
Origin:
EU

Myoview (Tetrofosmin)

Tetrofosmin, the active ingredient in Myoview, is a radiopharmaceutical presented as an injectable solution for intravenous use. It is employed in myocardial perfusion imaging to evaluate coronary artery disease, detect perfusion defects, and assess myocardial viability in adult patients.

GNH India supplies Myoview as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, and diagnostic imaging clinics worldwide. The product is manufactured under EU GMP standards and distributed to health‑care facilities across Europe, Asia and the Americas, ensuring consistent quality and traceability.

Manufacturer / TM Owner

Ge Healthcare Buchler Gmbh & Co. Kg

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Indications & Clinical Uses

  • Myoview (tetrofosmin) is used in nuclear cardiology to assess myocardial perfusion and coronary artery disease.
  • Myocardial perfusion imaging: Enables visualization of regional blood flow to identify perfusion defects.
  • Coronary artery disease detection: Helps locate areas of reduced perfusion caused by obstructive lesions.
  • Myocardial viability assessment: Differentiates viable from non‑viable myocardium for revascularisation planning.
  • Stress testing: Provides images during pharmacologic stress to evaluate inducible ischemia.
  • Rest imaging: Allows comparison of rest and stress perfusion for comprehensive assessment.

How It Works

  • Tetrofosmin is a lipophilic cationic complex that readily crosses cell membranes and accumulates in viable myocardial cells in proportion to regional blood flow. After intravenous injection, it is taken up by the myocardium, and its gamma‑emitting radionuclide allows single‑photon emission computed tomography (SPECT) to generate detailed perfusion images of the heart.

Side Effects

Adverse reactions to Myoview are generally related to the radiopharmaceutical nature of tetrofosmin and its intravenous administration.

Common Side Effects

  • Nausea
  • Headache
  • Flushing
  • Pain at the injection site

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Hypotension
  • Cardiac arrhythmia

Precautions & Warnings

  • Myoview should be used with caution in specific patient populations and clinical situations.
  • Pregnancy: Use only if the potential diagnostic benefit outweighs the radiation risk to the fetus.
  • Breastfeeding: Not recommended; consider withholding breast milk for an appropriate period.
  • Renal impairment: Evaluate renal function; altered clearance may affect image quality.
  • Thyroid disorders: Assess thyroid status as iodine‑based radiotracers can affect thyroid function.
  • Allergy: Discontinue immediately if signs of hypersensitivity occur.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Myoview may interact with other agents that influence radiation exposure or myocardial uptake.

Major Interactions (Avoid)

  • Concurrent use of other radiopharmaceuticals may increase cumulative radiation dose.
  • Beta‑blockers may reduce myocardial uptake of tetrofosmin.

Moderate Interactions (Monitor Closely)

  • Calcium channel blockers may alter distribution of the tracer.
  • Thyroid hormone therapy may affect radiotracer uptake.
  • Amiodarone may modify myocardial uptake patterns.

Frequently Asked Questions

Myoview is a radiopharmaceutical used in nuclear cardiology to perform myocardial perfusion imaging. It helps clinicians visualize blood flow to the heart muscle, detect areas of reduced perfusion caused by coronary artery disease, and assess the viability of myocardial tissue before therapeutic decisions.

Tetrofosmin is a lipophilic cation that readily enters viable heart cells. Its uptake is proportional to regional blood flow, so areas with good perfusion accumulate more tracer. The gamma emissions from the radionuclide are captured by SPECT cameras, producing detailed images of myocardial perfusion.

The administered activity of Myoview is determined by the prescribing physician based on the patient’s weight, the imaging protocol, and regulatory guidelines. Healthcare professionals calculate the appropriate dose to achieve optimal image quality while adhering to radiation safety standards.

Myoview contains a radioactive tracer, so it is generally avoided during pregnancy unless the diagnostic benefit clearly outweighs the potential fetal radiation risk. Breastfeeding is not recommended after administration; mothers should discuss appropriate interruption of nursing with their healthcare provider.

To order Myoview, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and any necessary import documentation.

The primary alternatives for myocardial perfusion imaging are Technetium‑99m sestamibi and Thallium‑201. Compared with Thallium‑201, tetrofosmin offers a lower radiation dose and faster imaging protocols. Relative to Technetium‑99m sestamibi, tetrofosmin provides comparable image quality but may have slightly different biodistribution, which can influence protocol selection.

Myoview must be stored refrigerated between 2 °C and 8 °C, protected from light, and should never be frozen or shaken. Before use, allow the vial to reach room temperature if required by the imaging protocol, and handle it with standard radiopharmacy precautions to avoid contamination.

Myoview is administered as an intravenous injection by a qualified healthcare professional. The dose is injected as a single bolus, followed by a short waiting period to allow myocardial uptake before the patient is positioned for SPECT imaging.

The most serious risks include severe allergic reactions such as anaphylaxis, significant hypotension, and cardiac arrhythmias that may occur during or shortly after injection. Immediate medical attention is required if any of these events are observed.

Myoview should not be used in patients with known hypersensitivity to tetrofosmin or any component of the formulation, in pregnant women unless absolutely necessary, and in individuals where the radiation exposure outweighs the diagnostic benefit, such as certain pediatric cases without clear indication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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