Product image of Myoview (Tetrofosmin) supplied by GNH India

Myoview

Active Ingredient:
Tetrofosmin
Origin:
EU

Myoview (Tetrofosmin)

Tetrofosmin, the active ingredient in Myoview, is a radiopharmaceutical presented as a sterile solution for intravenous injection. It is used for myocardial perfusion imaging to evaluate coronary artery disease in patients undergoing SPECT scans.

GNH India supplies Myoview as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and procurement teams worldwide.

Manufacturer / TM Owner

Ge Healthcare Ae

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Indications & Clinical Uses

  • Myoview (tetrofosmin) is employed in nuclear cardiology to assess myocardial perfusion and coronary artery disease.
  • Myocardial perfusion imaging: provides visualisation of blood flow to heart muscle during stress and rest phases.
  • Coronary artery disease evaluation: helps identify areas of reduced perfusion indicating obstructive lesions.
  • Ischemic heart disease assessment: supports detection of reversible perfusion defects.

How It Works

  • Tetrofosmin is a lipophilic cation that is taken up by viable myocardial cells in proportion to regional blood flow. After intravenous administration, it accumulates in the myocardium, allowing single‑photon emission computed tomography (SPECT) to generate high‑resolution images of perfusion distribution and identify areas of ischemia or infarction.

Side Effects

Adverse reactions may occur following administration of Myoview.

Common Side Effects

  • Nausea: mild to moderate discomfort after injection.
  • Vomiting: occasional emesis within the first hour.
  • Headache: transient headache reported by some patients.
  • Transient flushing: brief warmth or redness at the injection site.
  • Dizziness: mild light‑headedness during or after the procedure.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Severe hypotension: marked drop in blood pressure post‑administration.
  • Cardiac arrhythmia: abnormal heart rhythm potentially triggered by the tracer.
  • Radiation‑related injury: unlikely but possible with excessive exposure.
  • Thyroid dysfunction: rare alteration in thyroid hormone levels due to iodine content.

Precautions & Warnings

  • Prior to Myoview administration, clinicians should consider several safety measures.
  • Allergy assessment: verify no known hypersensitivity to tetrofosmin or related radiopharmaceuticals.
  • Pregnancy: avoid use unless the diagnostic benefit outweighs potential fetal radiation risk.
  • Renal impairment: assess kidney function as reduced clearance may affect tracer distribution.
  • Thyroid function: monitor because the compound contains iodine that can influence thyroid activity.
  • Radiation exposure: limit to necessary diagnostic procedures and follow ALARA principles.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Myoview may interact with other agents that influence cardiac imaging or iodine metabolism.

Major Interactions (Avoid)

  • Concurrent radiopharmaceuticals: may interfere with image interpretation.
  • Beta‑blockers: can blunt stress‑induced heart rate response, affecting perfusion results.
  • Thyroid hormone therapy: may alter iodine uptake and distribution.

Moderate Interactions (Monitor Closely)

  • Caffeine intake: can affect coronary vasodilation and perfusion imaging accuracy.
  • Nitrates: may modify coronary blood flow and impact tracer distribution.

Frequently Asked Questions

Myoview is a radiopharmaceutical containing tetrofosmin that is used in nuclear cardiology to perform myocardial perfusion imaging. It helps visualize blood flow to the heart muscle during stress and rest, aiding the assessment of coronary artery disease and ischemic heart conditions.

Tetrofosmin is a lipophilic cation that is taken up by viable myocardial cells in proportion to regional blood flow. After intravenous injection, it accumulates in heart muscle, allowing single‑photon emission computed tomography (SPECT) to create detailed images of perfusion and identify areas of reduced blood supply.

The specific dose of Myoview is determined by the prescribing physician based on the patient’s clinical scenario, imaging protocol and regulatory guidelines. Healthcare professionals calculate the appropriate activity to achieve optimal image quality while adhering to radiation safety standards.

Myoview contains a radioactive tracer, so its use in pregnancy is generally avoided unless the diagnostic benefit outweighs potential fetal risk. Limited data exist for breastfeeding; if administered, breastfeeding may need to be paused according to local guidelines to minimize infant exposure.

To order Myoview, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Myoview (tetrofosmin) is similar to other SPECT perfusion tracers such as thallium‑201 and technetium‑99m sestamibi. Compared with thallium‑201, tetrofosmin offers a lower radiation dose and longer half‑life, allowing flexible imaging times. Compared with sestamibi, it provides comparable image quality with a slightly different biodistribution, which may influence protocol selection.

Myoview should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. The vial should remain in its original packaging until use, and any unused portion should be disposed of according to local radiopharmaceutical waste regulations.

Myoview is administered as a sterile solution for intravenous injection. The prescribed activity is drawn into a syringe under aseptic conditions and injected into a peripheral vein, typically followed by a waiting period to allow tracer uptake before SPECT image acquisition.

Serious risks include rare anaphylactic reactions, severe hypotension, cardiac arrhythmias, and radiation‑related injury if exposure exceeds recommended limits. Patients should be monitored closely during and after administration, and any signs of allergic reaction or hemodynamic instability should be addressed immediately.

Myoview should be avoided in individuals with known hypersensitivity to tetrofosmin or any component of the formulation. It is also contraindicated in pregnant women unless essential, and caution is advised for patients with severe renal impairment, uncontrolled thyroid disorders, or those unable to tolerate intravenous injections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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