Product image of Myoview (Tetrofosmin) supplied by GNH India

Myoview

Active Ingredient:
Tetrofosmin
Origin:
EU

Myoview (Tetrofosmin)

Tetrofosmin, the active ingredient in Myoview, is a radiopharmaceutical presented as an injectable solution (kit for reconstitution) for intravenous use. It is employed to visualize myocardial perfusion during single‑photon emission computed tomography, aiding the assessment of coronary artery disease and myocardial viability in adult patients. It is indicated for adult patients undergoing evaluation for coronary artery disease, myocardial ischemia, and viability prior to revascularization procedures.

GNH India supplies Myoview as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, diagnostic centres and clinics worldwide, ensuring reliable cold‑chain logistics and regulatory compliance.

Manufacturer / TM Owner

Ge Healthcare As

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Indications & Clinical Uses

  • Myoview is used in cardiac imaging to assess myocardial blood flow and detect coronary artery disease.
  • Myocardial perfusion imaging (SPECT): provides quantitative images of regional blood flow to identify perfusion defects.
  • Evaluation of coronary artery disease: helps detect ischemic regions and guide therapeutic decisions.
  • Assessment of myocardial viability: distinguishes viable myocardium from scar tissue to inform revascularization planning.

How It Works

  • Tc-99m labeled tetrofosmin is a lipophilic cation that readily crosses cell membranes and accumulates in myocardial cells in proportion to regional blood flow. The localized radioactivity is then detected by gamma cameras during SPECT, producing images that reflect perfusion patterns across the heart muscle.

Side Effects

Adverse reactions to Myoview are generally related to the radiopharmaceutical nature of the product and the intravenous administration.

Common Side Effects

  • Nausea: mild, transient nausea occurring shortly after injection.
  • Flushing: temporary facial or upper body flushing.
  • Headache: mild to moderate headache reported post‑administration.
  • Injection site pain: brief discomfort at the venipuncture site.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical intervention.
  • Severe hypotension: marked drop in blood pressure that may need treatment.
  • Radiation‑induced skin reaction: localized skin changes at the injection site due to radiation exposure.

Precautions & Warnings

Prior to using Myoview, several safety considerations should be reviewed.

  • Renal impairment: assess renal function before administration as clearance may be reduced.
  • Pregnancy: use only if the diagnostic benefit outweighs potential fetal risk.
  • Breastfeeding: consider discontinuation of breastfeeding or assess infant exposure risk.
  • Concurrent radiopharmaceuticals: avoid co‑administration to prevent competitive binding.
  • Allergy to technetium: contraindicated in patients with known hypersensitivity to technetium‑99m compounds.
  • Store at 2‑8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Myoview may interact with certain drugs or agents that affect radiotracer distribution or imaging interpretation.

Major Interactions (Avoid)

  • Other Tc‑99m labeled agents: may compete for myocardial uptake and reduce image quality.
  • High‑dose iodinated contrast: can interfere with tracer distribution and compromise SPECT results.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: may alter myocardial perfusion patterns and affect tracer uptake.
  • Calcium channel blockers: can modify coronary blood flow influencing imaging outcomes.
  • Thyroid disorders: abnormal thyroid function may affect technetium kinetics.

Frequently Asked Questions

Myoview is a radiopharmaceutical containing tetrofosmin that is used in single‑photon emission computed tomography (SPECT) myocardial perfusion imaging. It helps visualize regional blood flow, detect coronary artery disease, and assess myocardial viability in adult patients.

Tetrofosmin is labeled with technetium‑99m and acts as a lipophilic cation. After intravenous injection it rapidly crosses cell membranes and accumulates in myocardial cells in proportion to the local blood flow, allowing gamma‑camera detection of perfusion patterns.

The administered activity of Myoview is determined by the prescribing physician based on patient weight, the imaging protocol, and the specifications of the SPECT equipment. The product is supplied as a kit for reconstitution and is given as a single intravenous injection.

Safety data for Myoview in pregnancy and lactation are limited. It should only be used when the potential diagnostic benefit justifies any possible risk to the fetus or infant, and the decision must be made by the treating physician after careful risk‑benefit assessment.

To order Myoview, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if required) and the necessary import documentation.

Myoview (tetrofosmin) and technetium‑99m sestamibi have comparable diagnostic performance. Tetrofosmin offers rapid myocardial uptake and relatively fast clearance, which can shorten imaging time, whereas sestamibi may show slightly higher liver uptake. Choice of agent often depends on local protocol preferences and availability.

Myoview must be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. The reconstituted solution should be used promptly according to the product’s stability guidelines and handled only by trained personnel.

Myoview is provided as a sterile injectable solution kit for reconstitution. After preparation, the radiopharmaceutical is administered intravenously, typically as a single bolus injection, followed by a waiting period before image acquisition as defined by the specific SPECT protocol.

Serious risks include severe allergic reactions such as anaphylaxis, marked hypotension, and radiation‑induced skin injury at the injection site. Patients should be monitored during and after injection, and any signs of a severe reaction should be managed immediately according to emergency guidelines.

Myoview is contraindicated in patients with known hypersensitivity to tetrofosmin or any component of the formulation. It should also be used with caution or avoided in individuals with severe renal impairment, uncontrolled thyroid disorders, or those who are pregnant or breastfeeding unless the diagnostic benefit clearly outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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