Product image of Myoview (Tetrofosmin) supplied by GNH India

Myoview

Active Ingredient:
Tetrofosmin
Origin:
EU

Myoview (Tetrofosmin)

Tetrofosmin, the active ingredient in Myoview, is a radiopharmaceutical presented as a 10 mCi (370 MBq) sterile solution for injection use. It is employed for myocardial perfusion imaging to assess coronary artery disease in adult patients.

GNH India supplies Myoview as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

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Indications & Clinical Uses

  • Myoview (tetrofosmin) is used in cardiac imaging to evaluate myocardial blood flow.
  • Myocardial perfusion imaging: provides quantitative assessment of regional blood flow at rest and stress.
  • Coronary artery disease assessment: helps identify ischemic territories and severity of disease.
  • Stress and rest cardiac SPECT imaging: enables visualization of perfusion defects during pharmacologic or exercise stress.

How It Works

  • Tetrofosmin forms a technetium‑99m complex that acts as a lipophilic cation. After intravenous injection it readily crosses cell membranes and is taken up by viable myocardial cells in proportion to regional blood flow, allowing single‑photon emission computed tomography (SPECT) to map perfusion and detect ischemic areas.

Side Effects

Adverse reactions may occur following administration of Myoview.

Common Side Effects

  • Nausea: mild, transient feeling of stomach upset.
  • Headache: mild to moderate intensity, usually resolves spontaneously.
  • Injection site pain: brief discomfort at the venipuncture site.
  • Flushing: transient warmth and reddening of the skin.
  • Dizziness: temporary light‑headedness.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Severe hypotension: marked drop in blood pressure, potentially symptomatic.
  • Cardiac arrhythmia: abnormal heart rhythm that may need monitoring.
  • Myocardial infarction: rare occurrence of heart attack post‑administration.
  • Radiation‑induced injury: unlikely but possible tissue effects from radiotracer exposure.

Precautions & Warnings

  • Prior to using Myoview, consider the following safety measures.
  • Pregnancy: Category C; use only if potential benefits justify the potential risk to the fetus.
  • Breastfeeding: discontinue nursing or discontinue the drug, as radiotracer may be excreted in milk.
  • Renal impairment: monitor patients with reduced kidney function, as clearance may be altered.
  • Thyroid disorders: avoid in patients with uncontrolled hyperthyroidism due to iodine uptake concerns.
  • Concurrent radiopharmaceuticals: do not administer other technetium‑99m agents within 24 hours to prevent interference.
  • Store at ambient temperature below 25°C: keep in the original shielded container, protect from light and moisture.

Avoid Interactions

Myoview may interact with other agents that affect imaging quality or hemodynamics.

Major Interactions (Avoid)

  • Other technetium‑99m labeled agents: competitive binding may reduce image quality.
  • Iodine‑containing contrast media: can interfere with tracer distribution and interpretation.
  • Beta‑blockers: may blunt heart rate response during stress testing.

Moderate Interactions (Monitor Closely)

  • Caffeine‑containing products: may diminish stress test sensitivity.
  • Certain antihypertensives: may alter hemodynamic response and affect perfusion results.

Frequently Asked Questions

Myoview is a technetium‑99m tetrofosmin radiopharmaceutical used for myocardial perfusion imaging. It helps clinicians assess blood flow to the heart muscle during rest and stress, aiding in the diagnosis of coronary artery disease and evaluation of cardiac function.

Tetrofosmin forms a lipophilic cationic complex with technetium‑99m that readily crosses cell membranes. Viable myocardial cells take up the tracer proportionally to regional blood flow, allowing SPECT cameras to create detailed images of perfusion and identify areas of reduced blood supply.

The prescribed activity of Myoview is determined by the ordering physician based on the specific imaging protocol, patient size, and equipment. Typical preparations contain 10 mCi (370 MBq) per vial, but the exact administered dose is set by the healthcare professional.

Myoview is classified as Pregnancy Category C, meaning it should be used only if the potential diagnostic benefit outweighs any risk to the fetus. For breastfeeding mothers, discontinuation of nursing or the drug is recommended because the radiotracer can be excreted in breast milk.

To order Myoview, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Myoview (tetrofosmin) and agents such as technetium‑99m sestamibi share similar mechanisms as lipophilic cations, but tetrofosmin has slightly higher myocardial uptake and faster liver clearance, which can improve image quality and reduce background activity in some protocols.

Myoview should be stored at ambient temperature below 25 °C, in its original shielded container. Protect the vial from light, moisture, and physical shock. Do not freeze. Use aseptic technique when preparing the dose for intravenous injection.

Myoview is administered as a sterile intravenous injection. The radiopharmaceutical is typically injected shortly before the imaging session, followed by a waiting period to allow distribution within the myocardium before acquisition of SPECT images.

Serious risks, though rare, include severe allergic reactions (anaphylaxis), marked hypotension, cardiac arrhythmias, myocardial infarction, and radiation‑related tissue injury. Immediate medical attention is required if any of these events occur.

Myoview should be avoided in patients with known severe hypersensitivity to tetrofosmin or any component of the formulation, in those who have received another technetium‑99m radiopharmaceutical within the past 24 hours, and in pregnant women unless the diagnostic benefit justifies the potential risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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