Product image of Myoview (Tetrofosmin) supplied by GNH India

Myoview

Active Ingredient:
Tetrofosmin
Origin:
EU

Myoview (Tetrofosmin)

Tetrofosmin, the active ingredient in Myoview, is a radiopharmaceutical presented as a 0.5 mg per vial injectable solution for intravenous use. It is employed in cardiac imaging to assess myocardial perfusion and viability in patients evaluated for coronary artery disease.

GNH India supplies Myoview as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Manufacturer / TM Owner

Ge Healthcare

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Indications & Clinical Uses

  • Myoview, containing tetrofosmin, is used in cardiac imaging to evaluate myocardial blood flow and viability.
  • Coronary artery disease: enables detection of perfusion defects during stress and rest SPECT imaging.
  • Myocardial viability assessment: helps differentiate viable from non‑viable myocardium for revascularization decisions.
  • Stress‑rest cardiac SPECT imaging: provides high‑quality images for evaluating regional perfusion under pharmacologic or exercise stress.

How It Works

  • Technetium‑99m tetrofosmin is a lipophilic cation that readily crosses cell membranes and accumulates in the mitochondria of viable myocardial cells in proportion to regional blood flow. After intravenous injection, the emitted gamma photons are captured by a gamma camera, producing images that reflect myocardial perfusion.

Side Effects

Adverse reactions to Myoview are generally infrequent but may occur following intravenous administration.

Common Side Effects

  • Injection site pain: mild discomfort at the site of administration.
  • Nausea: transient feeling of queasiness.
  • Headache: mild to moderate headache.
  • Flushing: temporary warmth or redness of skin.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Hypotension: sudden drop in blood pressure.
  • Cardiac arrhythmia: abnormal heart rhythm observed in rare cases.

Precautions & Warnings

  • When using Myoview, several precautions should be observed to ensure patient safety and product integrity.
  • Patient screening: assess for known hypersensitivity to technetium‑99m compounds before administration.
  • Pregnancy considerations: avoid use in pregnant women unless the diagnostic benefit outweighs potential risk.
  • Breastfeeding guidance: advise temporary cessation of breastfeeding or discard milk for 24 hours after injection.
  • Drug interactions: review concurrent medications that may affect myocardial perfusion or radionuclide distribution.
  • Radiation safety: follow institutional protocols to limit radiation exposure to staff and patients.
  • Store at 2‑8 °C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Myoview may interact with certain agents that influence cardiac perfusion or radionuclide handling.

Major Interactions (Avoid)

  • Beta‑blockers: can blunt stress‑induced heart rate response, affecting image interpretation.
  • Calcium channel blockers: may alter myocardial blood flow and reduce tracer uptake.

Moderate Interactions (Monitor Closely)

  • Vasodilators (e.g., nitroglycerin): may change perfusion patterns, requiring timing adjustments.
  • Thyroid hormones: can affect technetium metabolism, necessitating monitoring.
  • Chemotherapeutic agents: potential additive radiation exposure; evaluate risk‑benefit.

Frequently Asked Questions

Myoview is a radiopharmaceutical containing tetrofosmin used in nuclear medicine to perform myocardial perfusion imaging, helping detect coronary artery disease, assess myocardial viability, and conduct stress‑rest SPECT studies. It provides images of blood flow to the heart muscle.

Tetrofosmin, labeled with technetium‑99m, is a lipophilic cation that readily crosses cell membranes and accumulates in the mitochondria of viable myocardial cells in proportion to regional blood flow. After intravenous injection, the gamma emissions from technetium‑99m are captured by a gamma camera, producing perfusion images.

The prescribed dose of Myoview is determined by the ordering physician based on the imaging protocol, the patient’s weight, and the activity of technetium‑99m used for reconstitution. The product is supplied as a kit containing 0.5 mg tetrofosmin to be mixed with the appropriate amount of technetium‑99m.

The safety of Myoview in pregnant or nursing women has not been established. It should be used only if the diagnostic benefit outweighs any potential risk to the fetus or infant, and appropriate radiation protection measures should be applied.

To place an order, submit an enquiry on the Myoview product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including cold‑chain handling if needed—and necessary import documentation.

Myoview (technetium‑99m tetrofosmin) offers rapid myocardial uptake and fast clearance, providing high‑quality SPECT images with lower radiation dose compared with thallium‑201 agents. Compared with technetium‑99m sestamibi, tetrofosmin has similar imaging characteristics but may allow slightly shorter imaging times due to its faster hepatic clearance.

Myoview kits should be stored at 2‑8 °C, protected from light, and kept in the original packaging to maintain stability. Do not freeze or shake the vial. Once reconstituted with technetium‑99m, the solution should be used promptly according to the manufacturer’s instructions.

Myoview is administered intravenously as a single injection. The kit is reconstituted with technetium‑99m per the supplied instructions, and the resulting solution is injected into a peripheral vein. Imaging is performed at a defined interval after injection, depending on the stress or rest protocol selected by the nuclear cardiology team.

The most serious risks include rare allergic reactions such as anaphylaxis, significant hypotension, and cardiac arrhythmias. Because the product contains a radioactive isotope, radiation exposure to the patient and staff must be managed according to regulatory guidelines and institutional radiation safety protocols.

Myoview should be avoided in patients with known hypersensitivity to tetrofosmin, technetium‑99m compounds, or any component of the kit. It is also contraindicated in pregnant women unless the diagnostic benefit justifies the potential risk, and caution is advised in breastfeeding mothers and patients with severe uncontrolled cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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