Product image of Myoview (Tetrofosmin) supplied by GNH India

Myoview

Active Ingredient:
Tetrofosmin
Origin:
EU

Myoview (Tetrofosmin)

Tetrofosmin, the active ingredient in Myoview, is a radiopharmaceutical presented as a 10 mCi (370 MBq) sterile solution for injection for intravenous use. It enables visualization of myocardial blood flow, supporting the diagnosis and management of coronary artery disease and assessment of myocardial viability in cardiac SPECT studies.

GNH India supplies Myoview as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, clinics and cardiac imaging centres worldwide, with established distribution networks across Europe, Asia and the Americas, and adhering to stringent quality standards.

Manufacturer / TM Owner

Ge Healthcare B.V.

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Indications & Clinical Uses

Myoview (technetium‑99m tetrofosmin) is used in cardiac imaging to evaluate myocardial perfusion and related conditions.

  • Myocardial perfusion imaging: enables detection of regional blood flow defects during stress and rest studies.
  • Coronary artery disease detection: helps identify ischemic territories associated with obstructive lesions.
  • Myocardial viability assessment: distinguishes viable from scarred myocardium for revascularization planning.
  • Stress/rest cardiac SPECT imaging: provides comparative images to assess inducible ischemia.

How It Works

  • Technetium‑99m tetrofosmin is a lipophilic cation that readily crosses cell membranes and accumulates in mitochondria of viable myocardial cells in proportion to regional blood flow. After intravenous injection, the radiotracer is taken up by perfused myocardium, allowing gamma camera detection during single‑photon emission computed tomography (SPECT) to generate perfusion images. The distribution is rapid, with peak myocardial uptake occurring within minutes and clearance from non‑cardiac tissues enhancing image contrast.

Side Effects

Adverse reactions to Myoview are generally infrequent but may occur following intravenous administration of the radiopharmaceutical.

Common Side Effects

  • Injection site pain: mild discomfort at the venipuncture site.
  • Nausea: transient feeling of queasiness.
  • Headache: mild to moderate headache.

Serious or Rare Side Effects

  • Allergic reaction: urticaria, bronchospasm or anaphylaxis.
  • Hypotension: significant drop in blood pressure.
  • Arrhythmia: new onset cardiac rhythm disturbances.

Precautions & Warnings

Prior to using Myoview, clinicians should consider several precautionary measures to ensure patient safety and optimal image quality.

  • Pregnancy: use only if the diagnostic benefit outweighs potential fetal radiation risk.
  • Breastfeeding: discontinue nursing or pump and discard milk for 24 hours after administration.
  • Renal impairment: assess renal function as clearance may be reduced.
  • Thyroid disorders: consider iodine blockade to reduce thyroid uptake of free technetium.
  • Concurrent cardiac medications: beta‑blockers or nitrates may affect perfusion results; adjust protocol accordingly.

Store at ambient temperature: keep vials in original container, protect from light and moisture, and do not freeze.

Avoid Interactions

Myoview may interact with certain drugs or substances that influence myocardial blood flow, radiotracer distribution, or radiation safety.

Major Interactions (Avoid)

  • Thyroid hormone therapy: may increase thyroid uptake of free technetium, raising radiation exposure.
  • Iodine‑containing contrast agents: can compete with technetium uptake, reducing image quality.
  • High‑dose vasodilators: may alter myocardial perfusion patterns and affect interpretation.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: can blunt stress‑induced hyperemia, potentially leading to false‑negative results.
  • Calcium channel blockers: may modify coronary flow reserve, influencing tracer distribution.
  • Caffeine or methylxanthines: should be avoided before stress testing as they antagonize vasodilator agents.

Frequently Asked Questions

Myoview is a radiopharmaceutical used in cardiac nuclear medicine to image myocardial perfusion. It helps clinicians detect areas of reduced blood flow, evaluate coronary artery disease, and assess myocardial viability during stress and rest SPECT studies.

Tetrofosmin, labeled with technetium‑99m, is a lipophilic cation that rapidly enters viable heart muscle cells and accumulates in mitochondria proportionally to regional blood flow. Gamma cameras then detect the emitted radiation, producing detailed perfusion images of the myocardium.

The administered activity of Myoview is determined by the prescribing physician based on the imaging protocol and patient characteristics. A typical vial contains 10 mCi (370 MBq) of technetium‑99m tetrofosmin, but the exact dose is individualized for each study.

Myoview is classified as pregnancy category C, indicating that it should be used only if the diagnostic benefit justifies potential fetal radiation exposure. Breastfeeding mothers are advised to discontinue nursing for at least 24 hours or to express and discard milk during that period.

To order Myoview, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and necessary import documentation.

Myoview (technetium‑99m tetrofosmin) offers higher image quality and faster acquisition than thallium‑201, with lower radiation dose and better patient tolerance. Compared with technetium‑99m sestamibi, tetrofosmin has similar diagnostic performance but slightly faster myocardial uptake, allowing earlier imaging after injection.

Myoview should be stored at ambient temperature, protected from light and moisture, and kept in its original sealed vial. Do not freeze the product. Before use, allow the vial to reach room temperature if it has been stored in a cooler environment.

Myoview is administered as an intravenous injection of the sterile solution. The radiotracer is typically injected as a bolus, followed by a short waiting period to allow myocardial uptake before acquiring SPECT images during stress or rest phases.

Serious risks, although rare, include allergic reactions such as urticaria, bronchospasm or anaphylaxis, significant hypotension, and cardiac arrhythmias. Radiation exposure is also a consideration, particularly in pregnant patients, and should be justified by clinical benefit.

Myoview is contraindicated in patients with known hypersensitivity to tetrofosmin or any component of the formulation. It should also be avoided in pregnant women unless essential, and caution is advised in patients with severe renal impairment or uncontrolled thyroid disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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