Product image of Myoview (Tetrofosmin) supplied by GNH India

Myoview

Active Ingredient:
Tetrofosmin
Origin:
EU

Myoview (Tetrofosmin)

Tetrofosmin, the active ingredient in Myoview, is a radiopharmaceutical presented as an injectable solution for intravenous use. It enables visualization of myocardial blood flow, supporting diagnosis of coronary artery disease, assessment of myocardial viability, and perfusion imaging in patients undergoing cardiac evaluation and stress testing.

GNH India supplies Myoview as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, cardiac centers, and diagnostic imaging facilities worldwide, ensuring reliable global distribution and regulatory compliance. The product complies with EU pharmacopeial standards and is available for export to international markets.

Manufacturer / TM Owner

Ge Healthcare Bio-Sciences, S.A.U.

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Indications & Clinical Uses

  • Myoview (tetrofosmin) is used in cardiac imaging to assess myocardial perfusion and viability.
  • Myocardial perfusion imaging: provides quantitative assessment of blood flow to detect regional ischemia.
  • Coronary artery disease detection: helps identify obstructive lesions by highlighting perfusion defects.
  • Myocardial viability evaluation: distinguishes viable from scarred myocardium to guide revascularization decisions.

How It Works

  • Tetrofosmin is a lipophilic cationic complex that rapidly crosses cell membranes and distributes proportionally to regional myocardial blood flow. After intravenous injection, it is taken up by viable myocardial cells via passive diffusion driven by the negative mitochondrial membrane potential. The retained tracer emits gamma photons detectable by single‑photon emission computed tomography (SPECT), allowing visualization of perfusion patterns across the heart.

Side Effects

Adverse reactions to Myoview are generally infrequent but may occur following intravenous administration.

Common Side Effects

  • Nausea: mild transient nausea reported after injection.
  • Headache: occasional headache during or after the procedure.
  • Flushing: transient facial or upper body flushing.
  • Injection site pain: mild discomfort at the venous access site.

Serious or Rare Side Effects

  • Anaphylactic reaction: rare severe allergic response requiring immediate medical intervention.
  • Hypotension: sudden drop in blood pressure that may need monitoring.
  • Cardiac arrhythmia: rare occurrence of abnormal heart rhythm during imaging.

Precautions & Warnings

  • Prior to Myoview administration, clinicians should evaluate patient-specific factors and follow handling guidelines.
  • Pregnancy: unknown risk; avoid use unless clearly needed.
  • Breastfeeding: unknown safety; consider discontinuation during treatment.
  • Renal impairment: use with caution as clearance may be reduced.
  • Hypersensitivity: assess for prior reactions to radiopharmaceuticals.
  • Concomitant radiotracers: avoid overlapping administration of other nuclear medicine agents.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Myoview may interact with other agents that affect myocardial blood flow or imaging quality.

Major Interactions (Avoid)

  • Concurrent myocardial perfusion agents: may interfere with image interpretation.
  • Iodinated contrast media within 24 h: can alter tracer distribution and reduce image quality.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: can modify myocardial blood flow and affect tracer uptake.
  • Calcium channel blockers: may influence perfusion patterns.
  • Caffeine intake: can diminish tracer uptake if consumed within 12 h before imaging.
  • Antihistamines: may mask mild allergic reactions.

Frequently Asked Questions

Myoview is a radiopharmaceutical used for cardiac imaging, specifically myocardial perfusion imaging, detection of coronary artery disease, and evaluation of myocardial viability. It helps clinicians visualize blood flow to the heart muscle during stress and rest conditions, supporting diagnosis and treatment planning.

Tetrofosmin is a lipophilic cationic complex that distributes in proportion to regional myocardial blood flow. After intravenous injection, it enters viable heart cells and accumulates within mitochondria due to the negative membrane potential. The retained tracer emits gamma photons that are captured by SPECT cameras to produce detailed perfusion images.

The dose of Myoview is determined by the prescribing physician based on the specific imaging protocol, patient weight, and equipment calibration. A standard practice involves administering a calculated activity of the injectable solution intravenously shortly before the SPECT scan, but exact amounts are individualized and not disclosed here.

Safety data for Myoview in pregnancy and lactation are limited, and the product is classified as having an unknown risk. It should only be used when clearly needed and after a risk‑benefit assessment by the healthcare provider. Breastfeeding mothers should discuss potential risks with their clinician.

To order Myoview, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details (including cold‑chain if required), and any necessary import documentation.

Myoview (tetrofosmin) and technetium‑99m sestamibi are the most common SPECT myocardial perfusion tracers. Both provide high‑quality images, but tetrofosmin has slightly faster hepatic clearance, potentially reducing soft‑tissue interference. Choice often depends on local availability, imaging protocol, and physician preference.

Myoview must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. The vial should remain in its original packaging until use, and any unused portion must be discarded according to local radiopharmaceutical waste regulations.

Myoview is administered as an intravenous injection of the sterile injectable solution. The injection is performed by qualified personnel in a controlled environment, typically shortly before the SPECT imaging session. The exact timing and activity are defined by the imaging protocol prescribed by the physician.

The most serious risks include rare but severe allergic reactions such as anaphylaxis, sudden hypotension, and cardiac arrhythmias that may occur during or after injection. Immediate medical attention is required if any of these symptoms develop, and patients should be monitored according to standard nuclear medicine safety guidelines.

Myoview should be avoided in patients with known hypersensitivity to tetrofosmin or any component of the formulation. It is also contraindicated in individuals where the diagnostic benefit does not outweigh the potential risk, such as pregnant women without a clear indication, and in patients who have received other myocardial perfusion agents within a short interval that could compromise image quality.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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