Mypaid (Dihydrocodeine Tartrate)

Mypaid is an opioid analgesic that acts on the central nervous system to alleviate pain and suppress cough.

• Moderate pain: provides relief for conditions such as dental or musculoskeletal pain.
• Cough: reduces the frequency and intensity of cough associated with respiratory infections.
• Post‑operative pain: helps manage pain after minor surgical procedures.

• Dihydrocodeine tartrate binds to mu‑opioid receptors in the central nervous system, activating inhibitory pathways that decrease neuronal excitability. This receptor activation reduces the perception of pain and also depresses the cough reflex by acting on the medullary cough center, resulting in analgesic and antitussive effects.

Common Side Effects

• Nausea: feeling of sickness or urge to vomit.
• Constipation: reduced bowel movements and hard stools.
• Drowsiness: increased sleepiness or fatigue.
• Dizziness: sensation of light‑headedness or unsteadiness.
• Dry mouth: reduced salivation leading to a parched feeling.
• Vomiting: expulsion of stomach contents.

Serious or Rare Side Effects

• Respiratory depression: slowed or shallow breathing that may be life‑threatening.
• Severe hypotension: marked drop in blood pressure.
• Allergic reactions: rash, itching, swelling, or anaphylaxis.
• Seizures: uncontrolled electrical activity in the brain.
• Dependence or withdrawal: physical or psychological reliance on the drug.
• Hepatic dysfunction: liver enzyme abnormalities or injury.

Before prescribing Mypaid, clinicians should evaluate patient history and potential risk factors.

• Assess pain severity: ensure the drug is appropriate for the level of pain.
• Avoid in respiratory depression: contraindicated for patients with compromised breathing.
• Monitor for dependence: watch for signs of misuse or addiction.
• Use caution in the elderly: increased sensitivity to sedative effects.
• Avoid concomitant CNS depressants: limit use with alcohol, benzodiazepines, or other opioids.
• Store at ambient temperature: keep in the original container, protect from moisture and light.

Mypaid may interact with several medications, requiring careful management.

Major Interactions (Avoid)

• Other opioids: additive respiratory depression risk.
• Benzodiazepines: enhanced sedation and respiratory suppression.
• Alcohol: increased CNS depression.
• Central nervous system depressants: synergistic sedative effects.
• MAO inhibitors: potential for severe hypertension.

Moderate Interactions (Monitor Closely)

• CYP2D6 inhibitors (e.g., fluoxetine): may increase dihydrocodeine levels.
• Anticholinergics: may exacerbate dry mouth.
• Antihistamines: can augment drowsiness.
• SSRIs: monitor for serotonin syndrome.
• Diuretics: may affect blood pressure control.