Product image of Myrelez (Lanreotide Acetate) supplied by GNH India

Myrelez

Active Ingredient:
Lanreotide Acetate
Origin:
EU

Myrelez (Lanreotide Acetate)

Lanreotide acetate, the active ingredient in Myrelez, is a somatostatin analog presented as a long‑acting depot injectable solution for subcutaneous use. It treats acromegaly and gastroenteropancreatic neuroendocrine tumors in adult patients. It is administered as a long‑acting depot injection, allowing sustained hormone control with infrequent dosing. The formulation is approved for use in the European Union.

GNH India supplies Myrelez as a licensed, GDP‑compliant international pharmaceutical supplier, sourcing the product from EU manufacturers and serving hospitals, oncology centres, and pharmacies worldwide with reliable logistics and regulatory support.

Manufacturer / TM Owner

Amdipharm Limited

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Indications & Clinical Uses

Myrelez (lanreotide acetate) is used in endocrine and neuroendocrine disorders to control excess hormone secretion.

  • Acromegaly: reduces growth hormone and IGF‑1 levels, improving disease control and related symptoms.
  • Gastroenteropancreatic neuroendocrine tumors (GEP‑NET): controls tumor‑related hormone secretion and can stabilize disease progression.
  • Carcinoid syndrome: alleviates flushing and diarrhea caused by hormone‑secreting neuroendocrine tumors.

How It Works

  • Lanreotide acetate binds with high affinity to somatostatin receptors, primarily SSTR2 and SSTR5, on pituitary and neuroendocrine cells. This interaction inhibits adenylate cyclase activity, reduces intracellular cAMP, and suppresses the secretion of growth hormone, insulin‑like growth factor‑1, and other peptide hormones, leading to decreased tumor‑related hormone output and antiproliferative effects.

Side Effects

Common Side Effects

  • Injection site pain: mild discomfort at the subcutaneous injection site.
  • Diarrhea: loose stools occurring shortly after dosing.
  • Nausea: transient feeling of queasiness.
  • Hyperglycemia: elevated blood glucose levels, especially in diabetic patients.

Serious or Rare Side Effects

  • Gallbladder disease: formation of gallstones or biliary sludge.
  • Pancreatitis: inflammation of the pancreas presenting with severe abdominal pain.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.

Precautions & Warnings

Patients receiving Myrelez should be monitored for metabolic and biliary effects.

  • Glucose monitoring: assess blood sugar regularly, especially in diabetic individuals.
  • Gallbladder evaluation: perform ultrasound if abdominal pain or gallstone history is present.
  • Pituitary tumor assessment: monitor tumor size and visual fields during therapy.
  • Hepatic function: use caution in patients with moderate liver impairment.
  • Hypersensitivity: discontinue if signs of allergic reaction develop.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide acetate may interact with other agents affecting hormone levels or metabolism.

Major Interactions (Avoid)

  • Octreotide: additive hormonal suppression may increase risk of severe hyperglycemia.
  • Antidiabetic medications: may require dose adjustment due to lanreotide‑induced hyperglycemia.

Moderate Interactions (Monitor Closely)

  • Ketoconazole: can increase lanreotide plasma concentrations.
  • Glucocorticoids: may mask adrenal insufficiency symptoms.
  • Diuretics: may influence electrolyte balance and renal function.

Frequently Asked Questions

Myrelez (lanreotide acetate) is indicated for the treatment of acromegaly and for controlling hormone‑related symptoms in gastroenteropancreatic neuroendocrine tumors, including carcinoid syndrome. It helps normalize growth hormone and IGF‑1 levels in acromegaly and reduces excessive hormone secretion from neuroendocrine tumors.

Lanreotide acetate is a synthetic somatostatin analog that binds primarily to somatostatin receptor subtypes 2 and 5 on target cells. This binding inhibits adenylate cyclase, lowers intracellular cAMP, and suppresses the release of growth hormone, insulin‑like growth factor‑1, and other peptide hormones, providing hormonal control and antiproliferative effects.

The dosing regimen for Myrelez is individualized by the prescribing clinician based on the patient’s disease severity, response to therapy, and tolerability. Typically, the medication is administered as a long‑acting depot injection given subcutaneously at intervals determined by the treating physician.

Safety of Myrelez in pregnancy and lactation has not been established. It should be used only if the potential benefit justifies the potential risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss risks and alternatives with their healthcare provider.

To order Myrelez, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. The team then provides pricing, availability, shipping details (including cold‑chain logistics if needed), and assistance with import documentation.

The principal alternative to Myrelez is octreotide, another somatostatin analog. Both agents suppress growth hormone and neuroendocrine hormone secretion, but lanreotide is formulated as a long‑acting depot that can be administered every four weeks, whereas octreotide often requires more frequent dosing or a different depot formulation. Choice between them depends on patient preference, tolerability, and physician assessment.

Myrelez should be stored refrigerated at 2‑8 °C (36‑46 °F). Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial. If temporary storage at room temperature is unavoidable, limit exposure to no more than 24 hours and return the product to refrigeration promptly.

Myrelez is given as a subcutaneous injection using a pre‑filled syringe or vial. The formulation is a long‑acting depot that releases lanreotide slowly over several weeks, allowing dosing intervals typically ranging from four to eight weeks as determined by the prescribing clinician.

Serious risks include gallbladder disease such as gallstones or biliary sludge, acute pancreatitis, severe hyperglycemia that may require medical intervention, and hypersensitivity reactions that can progress to anaphylaxis. Patients should be educated to report abdominal pain, persistent nausea, sudden changes in blood glucose, or signs of an allergic reaction promptly.

Myrelez is contraindicated in individuals with known hypersensitivity to lanreotide acetate or any excipients in the formulation. Caution is advised for patients with severe hepatic impairment, uncontrolled diabetes, or a history of gallbladder disease. The drug should be used under close medical supervision in these populations.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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