Product image of Myrelez (Lanreotide Acetate) supplied by GNH India

Myrelez

Active Ingredient:
Lanreotide Acetate
Origin:
EU

Myrelez (Lanreotide Acetate)

Lanreotide acetate, the active ingredient in Myrelez, is a somatostatin analog presented as a subcutaneous formulation for subcutaneous use. It treats acromegaly and gastroenteropancreatic neuroendocrine tumors in adult patients.
GNH India supplies Myrelez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Amdipharm Limited

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Indications & Clinical Uses

Myrelez is a somatostatin analog used in endocrine‑related disorders.

  • Acromegaly: reduces excess growth hormone secretion and helps control disease progression.
  • Gastroenteropancreatic neuroendocrine tumors (GEP‑NET): inhibits hormone release and can stabilize tumor growth.
  • Hormone‑secreting neuroendocrine tumors: controls symptomatic hormone hypersecretion and improves clinical outcomes.

How It Works

  • Lanreotide acetate binds with high affinity to somatostatin receptors, primarily subtypes SSTR2 and SSTR5, on pituitary and neuroendocrine cells. This binding inhibits adenylate cyclase activity, reduces intracellular cAMP, and suppresses the secretion of growth hormone, insulin‑like growth factor‑1, and other endocrine hormones, thereby limiting tumor‑related hormone excess and slowing disease progression.

Side Effects

Adverse reactions may occur with lanreotide therapy.

Common Side Effects

  • Injection site pain or erythema
  • Diarrhea
  • Nausea or abdominal discomfort
  • Hyperglycemia or altered glucose tolerance
  • Gallbladder sludge or gallstones
  • Headache

Serious or Rare Side Effects

  • Acute pancreatitis
  • Severe hyperglycemia requiring medical intervention
  • Cardiac arrhythmias
  • Anaphylactic or severe allergic reactions
  • Injection‑site necrosis or infection
  • Severe hepatic dysfunction

Precautions & Warnings

Safety considerations are essential when using lanreotide.

  • Pregnancy: use only if the potential benefit justifies the potential risk to the fetus; limited data are available.
  • Breastfeeding: caution advised as the drug may be excreted in milk; consult a healthcare professional.
  • Renal impairment: monitor renal function and adjust therapy as needed.
  • Diabetes or impaired glucose tolerance: regularly assess blood glucose levels and manage hyperglycemia.
  • Gallbladder disease: monitor for signs of gallstone formation or biliary colic.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide may interact with other medicines.

Major Interactions (Avoid)

  • Concomitant use of other somatostatin analogs (e.g., octreotide) may cause additive hormonal suppression.
  • High‑dose insulin or insulin secretagogues: risk of severe hypoglycemia when glucose control is altered.

Moderate Interactions (Monitor Closely)

  • Oral hypoglycemic agents: may require dose adjustment due to altered glucose metabolism.
  • Medications affecting gastrointestinal motility (e.g., metoclopramide): potential for enhanced GI side effects.
  • CYP450 substrates with narrow therapeutic windows: monitor plasma levels as lanreotide can modestly affect hepatic enzyme activity.

Frequently Asked Questions

Myrelez, containing lanreotide acetate, is prescribed for adult patients with acromegaly and for those with gastroenteropancreatic neuroendocrine tumors. In both conditions the drug helps control excess hormone secretion and can stabilize disease progression.

Lanreotide acetate mimics the natural hormone somatostatin and binds to somatostatin receptors, especially subtypes SSTR2 and SSTR5. This binding blocks signaling pathways that stimulate growth hormone and other endocrine hormones, thereby reducing their secretion and limiting tumor‑related hormone excess.

The specific dose and dosing interval of Myrelez are determined by the prescribing physician based on the individual patient's condition, response, and tolerability. Healthcare professionals follow approved labeling and clinical guidelines when selecting the appropriate regimen.

Safety data for lanreotide acetate in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a qualified healthcare provider.

To request Myrelez, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain handling if needed) and any required import documentation.

Myrelez (lanreotide acetate) and other agents such as octreotide share a similar mechanism of receptor binding but differ in formulation and dosing frequency. Lanreotide is often administered as a long‑acting subcutaneous injection, allowing less frequent dosing, whereas octreotide may require more frequent injections or continuous infusion.

Myrelez should be stored in a refrigerator at 2‑8 °C. Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial to maintain stability and potency.

Myrelez is given by subcutaneous injection, typically into the abdomen or thigh. The injection is performed by a qualified healthcare professional or trained patient following aseptic technique and the specific instructions provided with the product.

Serious adverse events, though uncommon, include acute pancreatitis, severe hyperglycemia, cardiac arrhythmias, anaphylactic reactions, and injection‑site necrosis. Patients should be monitored for signs of these conditions and seek immediate medical attention if they occur.

Myrelez is contraindicated in patients with known hypersensitivity to lanreotide acetate or any excipients in the formulation. Caution is also advised for individuals with uncontrolled diabetes, severe gallbladder disease, or significant cardiac arrhythmias, and it should be avoided in such cases unless a specialist determines the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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