Product image of Myrelez (Lanreotide Acetate) supplied by GNH India

Myrelez

Active Ingredient:
Lanreotide Acetate
Origin:
EU

Myrelez (Lanreotide Acetate)

Lanreotide acetate, the active ingredient in Myrelez, is a somatostatin analog presented as a subcutaneous formulation for injection use. It is employed to control excess growth hormone secretion in acromegaly and to manage hormone‑producing neuroendocrine tumors.

GNH India supplies Myrelez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Amdipharm Limited

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Indications & Clinical Uses

Myrelez is a somatostatin analog used in disorders characterized by excess hormone secretion.

  • Acromegaly: normalises elevated growth hormone levels and reduces associated symptoms.
  • Gastroenteropancreatic neuroendocrine tumors: inhibits tumor‑related peptide hormone release and may slow disease progression.
  • Carcinoid syndrome: alleviates flushing, diarrhoea and other hormone‑driven symptoms associated with neuroendocrine tumours.

How It Works

  • Lanreotide acetate is a synthetic analogue of somatostatin that binds with high affinity to somatostatin receptor subtypes (SSTR2, SSTR5). Receptor activation inhibits adenylate cyclase activity, reducing cyclic AMP formation and suppressing the secretion of growth hormone, insulin‑like growth factor‑1 and other peptide hormones involved in tumour growth and metabolic regulation.

Side Effects

Adverse reactions may occur with lanreotide therapy.

Common Side Effects

  • Injection site pain or erythema
  • Diarrhoea
  • Nausea
  • Abdominal discomfort
  • Headache
  • Hyperglycaemia

Serious or Rare Side Effects

  • Gallbladder disease or cholelithiasis
  • Acute pancreatitis
  • Severe hyperglycaemia requiring medical intervention
  • Anaphylactic or severe allergic reactions

Precautions & Warnings

Lanreotide should be used with careful clinical monitoring.

  • Monitor glucose levels: risk of hyperglycaemia may require antidiabetic therapy adjustment.
  • Assess gallbladder status: patients are prone to gallstone formation.
  • Evaluate liver function: hepatic metabolism may be altered in impairment.
  • Use caution in severe renal impairment: dose may need modification.
  • Pregnancy and lactation: safety not established; avoid unless clearly needed.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide may interact with several drug classes.

Major Interactions (Avoid)

  • Other somatostatin analogues: combined use can cause excessive hormone suppression.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase lanreotide exposure.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: lanreotide can raise blood glucose, requiring dose adjustments.
  • Medications affecting gallbladder motility (e.g., estrogen therapy): may increase gallstone risk.
  • QT‑prolonging drugs: monitor cardiac rhythm for additive effects.

Frequently Asked Questions

Myrelez, containing lanreotide acetate, is prescribed for patients with acromegaly to control excess growth hormone, and for gastroenteropancreatic neuroendocrine tumors, including carcinoid syndrome, to reduce hormone‑related symptoms and help manage disease progression.

Lanreotide acetate mimics natural somatostatin and binds to somatostatin receptors, especially SSTR2 and SSTR5. This binding blocks adenylate cyclase, lowers cyclic AMP, and suppresses the release of growth hormone and other peptide hormones that drive tumor growth and metabolic disturbances.

The specific dose and dosing interval of Myrelez are determined by the prescribing clinician based on the individual’s disease severity, response to therapy, and other clinical factors. Patients should follow the prescriber’s instructions and not alter the regimen without medical advice.

Safety data for lanreotide acetate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Myrelez product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Myrelez is a long‑acting somatostatin analogue similar to octreotide but offers a longer dosing interval, often every 4‑8 weeks, which can improve convenience. Compared with pegvisomant, a growth‑hormone receptor antagonist, lanreotide works by suppressing hormone secretion rather than blocking its action, and the choice depends on patient response, tolerance and physician preference.

Myrelez should be stored refrigerated at 2‑8 °C. Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial. If temporary storage at room temperature is unavoidable, limit exposure to no more than 24 hours and return to refrigeration promptly.

Myrelez is given by subcutaneous injection, typically performed by a healthcare professional. The injection is administered into the abdomen or thigh using a pre‑filled syringe or autoinjector, following aseptic technique and the dosing schedule prescribed by the treating physician.

Serious adverse events include gallbladder disease (such as cholelithiasis), acute pancreatitis, severe hyperglycaemia that may require medical intervention, and rare but potentially life‑threatening allergic reactions. Patients should be monitored regularly for these conditions and instructed to report any concerning symptoms promptly.

Myrelez is contraindicated in patients with known hypersensitivity to lanreotide acetate or any of the formulation excipients. Caution is advised for individuals with severe uncontrolled diabetes, active gallbladder disease, or those who are pregnant or breastfeeding unless the benefits outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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