Product image of Myrelez (Lanreotide Acetate) supplied by GNH India

Myrelez

Active Ingredient:
Lanreotide Acetate
Origin:
EU

Myrelez (Lanreotide Acetate)

Lanreotide Acetate, the active ingredient in Myrelez, is a somatostatin analog presented as a sterile solution for subcutaneous use. It is employed to control excess growth hormone in acromegaly and to manage hormone‑secreting neuroendocrine tumors in adult patients. Myrelez is manufactured under strict GMP conditions and is available for bulk and unit‑dose orders. GNH India supplies Myrelez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide, adhering to stringent quality standards and reliable global logistics.

Manufacturer / TM Owner

Amdipharm Limited

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Indications & Clinical Uses

  • Myrelez, a somatostatin analog, is used in endocrine and oncologic pathways to regulate hormone secretion.
  • Acromegaly: reduces elevated growth hormone and insulin‑like growth factor‑1 levels, helping control disease activity.
  • Neuroendocrine tumors: inhibits secretion of tumor‑derived hormones and may slow tumor progression.
  • Carcinoid syndrome: alleviates flushing, diarrhea and abdominal pain associated with functional neuroendocrine tumors.

How It Works

  • Lanreotide acetate is a synthetic analogue of somatostatin that binds with high affinity to somatostatin receptor subtypes (particularly sst2 and sst5). Receptor activation inhibits adenylate cyclase activity, reducing cyclic AMP formation and consequently suppressing the secretion of growth hormone, insulin, glucagon, and various peptide hormones produced by neuroendocrine tumors.

Side Effects

Lanreotide acetate may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Injection site pain or erythema.
  • Diarrhea or loose stools.
  • Nausea or abdominal discomfort.
  • Headache.

Serious or Rare Side Effects

  • Gallstone formation or biliary colic.
  • Acute pancreatitis.
  • Severe hypersensitivity reactions, including anaphylaxis.

Precautions & Warnings

  • When prescribing Myrelez, clinicians should observe several safety considerations.
  • Monitor glucose levels: hyperglycemia may develop, especially in diabetic patients.
  • Assess gallbladder health: patients with a history of gallstones require periodic evaluation.
  • Evaluate renal function: dose adjustment may be needed in severe impairment.
  • Use caution in pregnancy: safety is not established; weigh benefits against potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide acetate can interact with other medicines, requiring attention to avoid or monitor effects.

Major Interactions (Avoid)

  • Octreotide: combined somatostatin analog therapy may increase risk of gallbladder disease.
  • Dopamine agonists: additive hypotensive effects may occur.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: may require adjustment of glucose‑lowering therapy due to altered glycemic control.
  • Warfarin: occasional changes in INR have been reported; monitor coagulation parameters.
  • CYP3A4 inhibitors/inducers: may affect lanreotide metabolism; observe for altered efficacy or toxicity.

Frequently Asked Questions

Myrelez is indicated for the long‑term management of acromegaly in adults and for the control of hormone‑secreting neuroendocrine tumors, including carcinoid syndrome. It helps lower excess growth hormone levels and reduces tumor‑related hormone secretion, improving clinical symptoms and disease control.

Lanreotide acetate mimics natural somatostatin and binds to somatostatin receptors, mainly sst2 and sst5, on pituitary and neuroendocrine cells. This binding inhibits adenylate cyclase, decreasing cyclic AMP and suppressing the release of growth hormone, insulin, glucagon, and other peptide hormones involved in disease activity.

The dosage of Myreotide is individualized by the prescribing clinician based on the patient’s condition, disease severity, and response to therapy. Dosing regimens typically involve subcutaneous injections administered at regular intervals, often monthly, but the exact schedule and amount are determined by the treating physician.

Safety of Myrelez during pregnancy and lactation has not been established. It should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women of child‑bearing potential should be advised of the unknown risks and use effective contraception.

To order Myrelez, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials, then provide pricing, availability, shipping details (including cold‑chain if needed) and assist with import documentation.

The primary alternative to Myrelez is octreotide, another somatostatin analogue. Both agents suppress hormone secretion, but lanreotide has a longer dosing interval (often monthly) compared with octreotide’s more frequent dosing. Clinical efficacy is comparable, while individual tolerability and injection‑site reactions may differ, influencing physician and patient preference.

Myrelez should be stored in a refrigerator at 2‑8 °C (36‑46 °F). Keep the product in its original packaging, protect it from light, and avoid freezing or shaking the vial. If temporary storage at controlled room temperature is unavoidable, limit exposure to no more than 24 hours and return to refrigeration promptly.

Myrelez is administered by subcutaneous injection, usually into the abdomen, thigh or upper arm. The injection is performed by a healthcare professional or a trained patient following aseptic technique. The recommended injection volume and site rotation are outlined in the prescribing information to minimize local reactions.

Serious adverse events include gallstone formation or biliary colic, acute pancreatitis, severe hyperglycemia, and hypersensitivity reactions such as anaphylaxis. Patients should be monitored for abdominal pain, jaundice, sudden changes in blood glucose, or signs of allergic reaction, and seek immediate medical attention if these occur.

Myrelez is contraindicated in individuals with known hypersensitivity to lanreotide acetate or any of the excipients in the formulation. Caution is advised for patients with severe hepatic impairment, uncontrolled diabetes, or active gallbladder disease. Pregnant or breastfeeding women should only use it when the potential benefit justifies the potential risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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