Product image of Myrelez (Lanreotide Acetate) supplied by GNH India

Myrelez

Active Ingredient:
Lanreotide Acetate
Origin:
EU

Myrelez (Lanreotide Acetate)

Lanreotide acetate, the active ingredient in Myrelez, is a somatostatin analog presented as a sterile solution for subcutaneous use. It is employed in the management of acromegaly and somatostatin receptor‑positive neuroendocrine tumors in adult patients.
GNH India supplies Myrelez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Amdipharm Limited

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Indications & Clinical Uses

Myrelez is a somatostatin analog used to control hormone‑driven conditions and certain tumor types.

  • Acromegaly: reduces excess growth hormone secretion and can shrink pituitary adenomas.
  • Somatostatin receptor‑positive neuroendocrine tumors: inhibits tumor growth and hormone‑related symptoms.
  • Carcinoid syndrome: alleviates flushing, diarrhea and other secretory manifestations associated with functional neuroendocrine tumors.

How It Works

  • Lanreotide acetate is a synthetic analogue of the peptide hormone somatostatin. After subcutaneous injection it binds with high affinity to somatostatin receptor subtypes (mainly sst2 and sst5) on pituitary and neuroendocrine cells, suppressing cyclic AMP formation and calcium influx, which in turn inhibits secretion of growth hormone, insulin‑like growth factor‑1 and various peptide hormones that drive tumor proliferation.

Side Effects

Adverse reactions may occur with any somatostatin analogue.

Common Side Effects

  • Injection site pain or erythema
  • Nausea or vomiting
  • Abdominal discomfort or diarrhea
  • Headache
  • Mild hyperglycemia
  • Fatigue

Serious or Rare Side Effects

  • Gallbladder disease or cholelithiasis
  • Acute pancreatitis
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Cardiac arrhythmias
  • Significant hyperglycemia requiring medical intervention
  • Severe injection‑site infection or necrosis

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor for known safety concerns.

  • Blood glucose monitoring: assess baseline glucose and watch for hyperglycemia.
  • Gallbladder assessment: consider ultrasonography in patients with a history of gallstones.
  • Hypersensitivity: discontinue if signs of allergic reaction appear.
  • Renal/hepatic function: adjust use in severe impairment.
  • Pregnancy and lactation: use only if potential benefit justifies potential risk, as safety data are limited.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide may alter the pharmacokinetics or pharmacodynamics of several agents.

Major Interactions (Avoid)

  • Concomitant cyclosporine: increased risk of hyperglycemia and nephrotoxicity.
  • Co‑administration with other somatostatin analogues (e.g., octreotide): additive hormonal suppression.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise lanreotide exposure.

Moderate Interactions (Monitor Closely)

  • Antidiabetic medications: possible need for dose reduction due to altered glucose control.
  • Oral contraceptives: potential reduction in efficacy, monitor menstrual cycles.
  • Drugs metabolized by CYP2C9: monitor plasma levels for possible interaction.

Frequently Asked Questions

Myrelez is indicated for the treatment of acromegaly, a disorder of excess growth hormone, and for somatostatin receptor‑positive neuroendocrine tumors, including those that cause carcinoid syndrome. It helps control hormone secretion and can reduce tumor size in these patient populations.

Lanreotide acetate mimics natural somatostatin and binds to somatostatin receptors, primarily sst2 and sst5, on endocrine and tumor cells. This binding blocks intracellular signaling pathways that stimulate hormone release and cell proliferation, thereby lowering growth hormone levels and inhibiting tumor growth.

The dosage of Myrelez is individualized by the prescribing clinician based on the patient’s condition, response, and tolerance. The prescriber determines the appropriate amount, frequency, and duration of subcutaneous administration according to current clinical guidelines.

Safety data for lanreotide acetate in pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To request Myrelez, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and required import documentation.

Myrelez (lanreotide acetate) and other agents such as octreotide share a similar mechanism of receptor binding but differ in formulation, dosing frequency, and pharmacokinetic profile. Lanreotide is often administered as a long‑acting injectable every 4–8 weeks, which may offer greater convenience compared with shorter‑acting alternatives.

Myrelez must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. If temporary storage at room temperature is unavoidable, limit exposure to no more than 30 minutes and return the product to refrigeration promptly.

Myrelez is given by subcutaneous injection, typically into the abdomen or thigh. The injection is performed by a trained healthcare professional or, after appropriate instruction, by the patient or caregiver using the supplied pre‑filled syringe or autoinjector device.

Serious risks include gallbladder disease or cholelithiasis, acute pancreatitis, severe allergic reactions such as anaphylaxis, significant hyperglycemia that may require medical treatment, and rare cardiac arrhythmias. Patients should be monitored regularly for these events, and therapy should be stopped if they occur.

Myrelez is contraindicated in patients with known hypersensitivity to lanreotide acetate or any of the formulation excipients. Caution is advised in individuals with severe hepatic or renal impairment, uncontrolled diabetes, or a history of gallbladder disease, and it should be avoided in pregnancy unless clearly justified.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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