Product image of Myrelez (Lanreotide Acetate) supplied by GNH India

Myrelez

Active Ingredient:
Lanreotide Acetate
Origin:
EU

Myrelez (Lanreotide Acetate)

Lanreotide acetate, the active ingredient in Myrelez, is a somatostatin analog presented as a sterile aqueous solution for subcutaneous injection. It is used to control excess growth hormone in patients with acromegaly and to manage hormone‑secreting neuroendocrine tumors.
GNH India supplies Myrelez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Amdipharm Limited

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Indications & Clinical Uses

Myrelez, a somatostatin analog, is employed in conditions driven by excess hormone secretion.

  • Acromegaly: reduces growth hormone levels and can shrink pituitary adenomas.
  • Gastroenteropancreatic neuroendocrine tumors: controls hormone‑related symptoms and slows tumor progression.
  • Carcinoid syndrome: alleviates flushing, diarrhea and other secretory symptoms.

How It Works

  • Lanreotide acetate is a synthetic analogue of somatostatin that binds with high affinity to somatostatin receptor subtypes (particularly sst2 and sst5). Receptor activation inhibits adenylate cyclase, reduces intracellular cAMP, and suppresses the secretion of growth hormone, insulin‑like growth factor‑1, and various gastrointestinal hormones, thereby limiting tumor growth and hormone‑mediated clinical effects.

Side Effects

Adverse reactions may occur with lanreotide therapy.

Common Side Effects

  • Injection site pain or erythema
  • Diarrhea
  • Nausea
  • Abdominal pain or discomfort
  • Constipation
  • Headache

Serious or Rare Side Effects

  • Gallstone formation or biliary colic
  • Hyperglycemia or new‑onset diabetes mellitus
  • Acute pancreatitis
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Significant injection‑site necrosis or infection

Precautions & Warnings

Patients should be monitored for specific safety considerations before and during treatment.

  • Glucose monitoring: assess blood sugar levels, especially in diabetic patients.
  • Gallbladder assessment: evaluate for gallstones or biliary disease prior to initiation.
  • Hypersensitivity: check for known allergy to lanreotide or formulation components.
  • Dose adjustment: consider renal or hepatic impairment when determining dosing.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk, as safety data are limited.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide may interact with other medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Concomitant use with other somatostatin analogues (e.g., octreotide) due to additive hormonal suppression.
  • Co‑administration with insulin or oral hypoglycemics may cause severe hypoglycemia; dose adjustments are required.

Moderate Interactions (Monitor Closely)

  • Drugs that affect gastrointestinal motility (e.g., anticholinergics) may exacerbate constipation.
  • CYP450 substrates metabolized by the liver may have altered plasma levels; monitor therapeutic response.
  • Vaccines: live attenuated vaccines may have reduced efficacy; schedule vaccination appropriately.

Frequently Asked Questions

Myrelez (lanreotide acetate) is indicated for the management of acromegaly and for controlling hormone‑related symptoms in patients with gastroenteropancreatic neuroendocrine tumors and carcinoid syndrome.

Lanreotide acetate mimics natural somatostatin, binding to somatostatin receptors (mainly sst2 and sst5). This binding blocks adenylate cyclase activity, lowers cAMP levels, and suppresses the secretion of growth hormone, insulin‑like growth factor‑1, and various gastrointestinal hormones, thereby reducing tumor growth and hormone‑mediated effects.

The dosage of Myrelez is individualized. A qualified prescriber determines the appropriate dose, injection interval, and treatment duration based on the patient’s specific condition, response, and clinical guidelines.

Safety data for lanreotide acetate in pregnancy and lactation are limited. It should be used only if the potential therapeutic benefit justifies any potential risk to the fetus or infant, and the decision should be made by the treating physician.

To place an order, submit an enquiry on the Myrelez product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and necessary import documentation.

Myrelez (lanreotide) and other analogues such as octreotide share a similar mechanism of receptor activation but differ in formulation and dosing frequency. Lanreotide is typically administered as a long‑acting depot injection every 4–8 weeks, offering less frequent dosing compared with some short‑acting alternatives.

Myrelez should be stored at 2‑8 °C in a refrigerator. Keep the product in its original packaging, protect it from light, and do not freeze or shake the vial before use.

Myrelez is given by subcutaneous injection, usually into the abdomen or thigh. The injection is performed by a healthcare professional or a trained patient following aseptic technique and the prescriber’s instructions.

Serious risks include gallstone formation, hyperglycemia or new‑onset diabetes, acute pancreatitis, and severe allergic reactions such as anaphylaxis. Patients should be monitored for these events and instructed to seek immediate medical attention if symptoms arise.

Myrelez is contraindicated in patients with known hypersensitivity to lanreotide acetate or any excipients in the formulation. Caution is advised for individuals with uncontrolled diabetes, active gallbladder disease, or severe hepatic impairment, and it should be avoided in pregnancy unless clearly needed.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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