Product image of Myrelez (Lanreotide Acetate) supplied by GNH India

Myrelez

Active Ingredient:
Lanreotide Acetate
Origin:
EU

Myrelez (Lanreotide Acetate)

Lanreotide acetate, the active ingredient in Myrelez, is a somatostatin analog presented as an injectable formulation for subcutaneous use. It reduces excess growth hormone in adults with acromegaly and helps control hormone‑secreting neuroendocrine tumors.

GNH India supplies Myrelez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Amdipharm Limited

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Indications & Clinical Uses

  • Myrelez is a somatostatin analog indicated for conditions involving excess hormone secretion.
  • Acromegaly: lowers circulating growth hormone levels and can reduce tumor size in patients with pituitary adenomas.
  • Neuroendocrine tumors: controls hormone secretion and may slow tumor progression in patients with functional gastroenteropancreatic neuroendocrine tumors.

How It Works

  • Lanreotide acetate is a synthetic analogue of somatostatin that binds with high affinity to somatostatin receptor subtypes (particularly sst2 and sst5). Receptor activation inhibits adenylate cyclase activity, reducing cyclic AMP and calcium influx, which suppresses the secretion of growth hormone, insulin, glucagon, and various peptide hormones produced by neuroendocrine cells.

Side Effects

Common Side Effects

  • Injection site pain or erythema
  • Diarrhea or loose stools
  • Nausea and abdominal discomfort
  • Headache
  • Hyperglycemia or elevated blood glucose
  • Fatigue

Serious or Rare Side Effects

  • Gallstone formation or biliary colic
  • Acute pancreatitis
  • Severe allergic reactions (anaphylaxis, angioedema)
  • Marked hyperglycemia requiring medical intervention
  • Cardiac arrhythmias
  • Hepatic dysfunction

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate relevant patient factors and monitor for adverse events.
  • Monitor glucose: patients with diabetes may need tighter glycemic control.
  • Assess gallbladder: consider baseline imaging due to risk of gallstones.
  • Check for hypersensitivity: discontinue if severe allergic reaction occurs.
  • Pregnancy considerations: use only if potential benefit justifies potential risk.
  • Avoid in severe hepatic impairment: monitor liver function closely.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Lanreotide may interact with several concomitant medications, requiring clinical vigilance.

Major Interactions (Avoid)

  • Octreotide: additive somatostatin effects may increase risk of gallstones.
  • Cyclosporine: may raise lanreotide plasma concentrations.
  • Antidiabetic agents: hyperglycemic effect of lanreotide may necessitate dose adjustment.
  • Hormonal therapies (e.g., estrogen): may blunt lanreotide efficacy.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: monitor heart rate and blood pressure.
  • ACE inhibitors: watch for additive hypotensive effects.

Frequently Asked Questions

Myrelez is prescribed for adults with acromegaly to lower excessive growth hormone production and for patients with functional neuroendocrine tumors to control hormone secretion and help manage tumor growth.

Lanreotide acetate mimics the natural hormone somatostatin. It binds to somatostatin receptors on pituitary and neuroendocrine cells, inhibiting adenylate cyclase and reducing cyclic AMP, which suppresses the release of growth hormone and other peptide hormones.

The dosing regimen for Myrelez is individualized. A qualified prescriber determines the appropriate dose, frequency, and duration based on the patient’s condition, response, and clinical guidelines.

Safety data in pregnancy and lactation are limited. Myrelez should be used only if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made by the treating physician.

To request Myrelez, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required), and necessary import documentation.

The primary alternative is octreotide, another somatostatin analogue. Both agents suppress hormone secretion, but lanreotide has a longer dosing interval (often every 4 weeks) compared with octreotide’s more frequent dosing, which can improve convenience for some patients.

Myrelez should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use to maintain stability.

Myrelez is given as a subcutaneous injection, typically by a healthcare professional. The injection is administered into the abdominal wall or thigh, following aseptic technique and the specific instructions provided by the prescriber.

Serious risks include gallstone formation, acute pancreatitis, severe hyperglycemia, and allergic reactions such as anaphylaxis. Patients should be monitored for abdominal pain, unexplained fever, skin rash, or signs of infection, and seek immediate medical attention if these occur.

Myrelez is contraindicated in patients with known hypersensitivity to lanreotide or any of its excipients. Caution is advised for individuals with severe hepatic impairment, uncontrolled diabetes, or active gallbladder disease, and it should be avoided in pregnant women unless clearly indicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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