Product image of Myrlosar Comp (Losartan Potassium, Hydrochlorothiazide) supplied by GNH India

Myrlosar Comp

Active Ingredient:
Losartan Potassium, Hydrochlorothiazide
Origin:
EU

Myrlosar Comp (Losartan Potassium, Hydrochlorothiazide)

Losartan potassium and hydrochlorothiazide, the active ingredients in Myrlosar Comp, are an angiotensin II receptor blocker and a thiazide diuretic presented as an oral tablet for systemic use. They treat hypertension in adult patients by lowering blood pressure and reducing fluid overload, through complementary mechanisms.

GNH India supplies Myrlosar Comp as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality, safety and regulatory compliance across all markets. Our distribution network guarantees timely delivery and reliable product availability for healthcare providers.

Manufacturer / TM Owner

Aristo Pharma Gmbh (Art 57)

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Indications & Clinical Uses

  • Myrlosar Comp, a combination antihypertensive, acts on the renin‑angiotensin system and renal sodium handling to control high blood pressure.
  • Hypertension: lowers systolic and diastolic blood pressure in patients with essential hypertension.
  • Cardiovascular risk reduction: helps decrease the risk of stroke and heart attack associated with uncontrolled hypertension.
  • Renal protection in diabetes: provides kidney protective effects in patients with diabetic nephropathy when used as part of a comprehensive treatment plan.

How It Works

  • Losartan potassium selectively blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction, aldosterone release and sympathetic activation. Hydrochlorothiazide acts on the distal convoluted tubule, inhibiting NaCl reabsorption, which increases urinary sodium and water excretion, reduces plasma volume and lowers peripheral resistance. The combined actions produce additive blood‑pressure reduction through vascular relaxation and decreased fluid overload, resulting in sustained control of arterial pressure.

Side Effects

Myrlosar Comp may cause a range of adverse reactions, varying from mild to severe.

Common Side Effects

  • Dizziness
  • Headache
  • Increased urination
  • Electrolyte disturbances (e.g., low potassium)
  • Fatigue

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis)
  • Acute kidney injury
  • Hyperkalemia
  • Significant drop in blood pressure (hypotension)

Precautions & Warnings

  • Before prescribing Myrlosar Comp, clinicians should consider several safety precautions.
  • Monitor blood pressure: ensure adequate control and avoid hypotension.
  • Assess renal function: check serum creatinine and eGFR prior to initiation and periodically.
  • Check electrolytes: especially potassium and sodium levels during therapy.
  • Use caution in pregnancy: avoid unless clearly needed, as safety data are limited.
  • Review concomitant medications: avoid combining with other potassium‑sparing agents or ACE inhibitors without supervision.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Myrlosar Comp can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Potassium‑sparing diuretics: risk of hyperkalemia.
  • ACE inhibitors or other ARBs: may cause excessive renal impairment.
  • Lithium: increased lithium toxicity.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may reduce antihypertensive effect.
  • Other antihypertensives: may lead to additive blood‑pressure lowering.
  • Antidiabetic agents: blood‑glucose levels may require adjustment.

Frequently Asked Questions

Myrlosar Comp is a prescription combination of losartan potassium and hydrochlorothiazide indicated for the treatment of hypertension. It lowers blood pressure by blocking angiotensin II receptors and promoting diuresis, helping patients achieve target blood‑pressure levels and reduce cardiovascular risk.

Losartan potassium is an angiotensin II receptor blocker (ARB). It selectively binds to AT1 receptors on blood‑vessel smooth muscle and adrenal glands, preventing angiotensin II from causing vasoconstriction and aldosterone release. This leads to relaxed vessels, reduced sodium retention and lower blood pressure.

The specific dose of Myrlosar Comp is determined by the prescribing clinician based on the patient’s blood‑pressure readings, renal function, and other medical considerations. Dosage may be adjusted over time, and patients should follow the exact instructions provided on the prescription label.

Safety of Myrlosar Comp in pregnancy has not been established, and it is generally avoided unless the potential benefit outweighs the risk. Breastfeeding mothers should consult their healthcare provider, as the drug can be excreted in milk and may affect the infant.

To request Myrlosar Comp, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with single‑component agents, Myrlosar Comp offers combined blockade of the renin‑angiotensin system and diuretic‑induced fluid loss, often achieving greater blood‑pressure reduction at lower individual doses. It may be preferred when monotherapy does not provide sufficient control, but clinicians consider patient tolerance, renal function and electrolyte balance.

Myrlosar Comp tablets should be stored at ambient temperature, below 25 °C, in the original blister pack or container. Protect the product from moisture, heat and direct sunlight to maintain potency throughout its shelf life.

Myrlosar Comp is taken orally, usually once daily, with or without food as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.

The most serious risks include severe allergic reactions (anaphylaxis), acute kidney injury, hyperkalemia, and marked hypotension. Patients should be educated to seek immediate medical attention if they experience swelling, difficulty breathing, sudden loss of urine output, severe dizziness or fainting.

Myrlosar Comp is contraindicated in patients with known hypersensitivity to losartan, hydrochlorothiazide, or any component of the formulation. It should also be avoided in individuals with severe renal impairment, anuria, or those taking other potassium‑sparing agents without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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