Product image of Myrlosar (Losartan Potassium) supplied by GNH India

Myrlosar

Active Ingredient:
Losartan Potassium
Origin:
EU

Myrlosar (Losartan Potassium)

Losartan potassium, the active ingredient in Myrlosar, is an Angiotensin II receptor blocker (ARB) presented as an oral tablet for oral use. It is prescribed to manage high blood pressure and related cardiovascular conditions in adult patients. By selectively antagonizing angiotensin II type 1 receptors, the drug relaxes blood vessels, lowers systemic vascular resistance, and helps prevent complications such as stroke and heart failure.

GNH India supplies Myrlosar as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aristo Pharma Gmbh (Art 57)

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Indications & Clinical Uses

Losartan potassium is used to treat conditions related to the renin‑angiotensin system and cardiovascular disease.

  • Hypertension: lowers blood pressure and reduces risk of cardiovascular events.
  • Heart failure: improves symptoms and decreases hospitalization rates in patients with reduced ejection fraction.
  • Diabetic nephropathy: slows progression of kidney disease in patients with type 2 diabetes.
  • Stroke risk reduction: helps lower the likelihood of stroke in patients with hypertension and additional risk factors.

How It Works

  • Losartan potassium selectively blocks angiotensin II type 1 (AT1) receptors on vascular smooth‑muscle cells and adrenal glands, preventing angiotensin II‑mediated vasoconstriction and aldosterone release. This inhibition leads to vasodilation, reduced sodium and water retention, and ultimately a decrease in systemic blood pressure and cardiovascular strain.

Side Effects

Losartan potassium may cause a range of adverse reactions, which are generally categorized by frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Headache: mild to moderate intensity.
  • Fatigue: feeling unusually tired.
  • Upper respiratory infection: nasopharyngitis or mild cough.
  • Hyperkalemia: elevated blood potassium levels.

Serious or Rare Side Effects

  • Angioedema: swelling of the face, lips, tongue or throat.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Acute kidney injury: sudden decline in renal function.
  • Hepatic injury: abnormal liver enzyme elevations.
  • Neutropenia: low white‑blood‑cell count.

Precautions & Warnings

When prescribing Myrlosar, clinicians should consider several safety measures.

  • Monitor blood pressure: check regularly to ensure therapeutic effect.
  • Assess renal function: evaluate serum creatinine and eGFR before and during therapy.
  • Check electrolytes: especially potassium levels.
  • Avoid in patients with known hypersensitivity to ARBs.
  • Pregnancy: contraindicated in second and third trimester due to fetal risk.
  • Store at room temperature: keep in original container, protect from moisture and light.

Avoid Interactions

Losartan potassium can interact with other medicines, requiring attention to the level of risk.

Major Interactions (Avoid)

  • Concomitant use with aliskiren in diabetic patients: increased risk of renal impairment.
  • Dual blockade with ACE inhibitors or other ARBs: higher incidence of hypotension and hyperkalemia.
  • Potassium‑sparing diuretics (e.g., spironolactone): may cause dangerous hyperkalemia.
  • NSAIDs (high‑dose or chronic): can reduce antihypertensive effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • Lithium: may increase lithium levels, risking toxicity.
  • Cyclosporine or tacrolimus: can elevate serum creatinine.
  • Rifampin: may reduce losartan plasma concentrations.
  • Thiazide diuretics: may enhance antihypertensive effect, requiring dose adjustment.

Frequently Asked Questions

Myrlosar contains losartan potassium, an ARB indicated for the treatment of hypertension, heart failure, diabetic nephropathy, and for reducing stroke risk in appropriate patients. By blocking angiotensin II receptors, it lowers blood pressure and helps protect target organs from damage.

Losartan potassium selectively antagonizes angiotensin II type 1 (AT1) receptors on vascular smooth‑muscle and adrenal tissue. This blocks vasoconstriction and aldosterone secretion, producing vasodilation, reduced sodium‑water retention, and ultimately a decrease in systemic blood pressure.

The dosage of Myrlosar is individualized by the prescribing clinician based on the patient’s blood pressure, renal function, and co‑existing conditions. Typical starting doses range from 25 mg to 50 mg once daily, with adjustments made as needed to achieve target blood pressure.

Losartan potassium is classified as pregnancy category D because it can cause fetal toxicity, especially in the second and third trimesters; it should be discontinued in pregnant women. Limited data are available for breastfeeding, and the drug is generally not recommended unless the benefit outweighs potential risk.

To place an order, submit an enquiry on the Myrlosar product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with ACE inhibitors, losartan offers a similar blood‑pressure‑lowering effect but a lower incidence of cough and angio‑edema. Unlike calcium‑channel blockers, it directly blocks the renin‑angiotensin system, providing renal protective benefits in diabetic patients. Choice of therapy depends on patient profile and tolerability.

Myrlosar tablets should be stored at room temperature, below 25 °C, in the original packaging to protect from moisture and light. Do not store in bathrooms or near heat sources. Keep out of reach of children and discard any tablets that appear discoloured or damaged.

Myrlosar is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed unless specifically instructed by a healthcare professional. Consistent timing each day helps maintain stable blood‑pressure control.

Serious adverse events, though uncommon, include angio‑edema, severe hypotension, acute kidney injury, hyperkalemia, and hepatic dysfunction. Patients should be educated to seek immediate medical attention if they develop swelling of the face or throat, sudden dizziness, or unexplained fatigue. Regular monitoring mitigates these risks.

Myrlosar is contraindicated in patients with known hypersensitivity to losartan or any ARB, in those with severe hepatic impairment, and in pregnant women beyond the first trimester. Caution is also advised for individuals with bilateral renal artery stenosis or those taking concomitant potassium‑sparing agents without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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