Product image of Mystrelle (Ethinylestradiol, Etonogestrel) supplied by GNH India

Mystrelle

Active Ingredient:
Ethinylestradiol, Etonogestrel
Origin:
EU

Mystrelle (Ethinylestradiol, Etonogestrel)

Ethinylestradiol and etonogestrel, the active ingredients in Mystrelle, are a combined estrogen‑progestogen contraceptive presented as a vaginal ring for intravaginal use. Approved in the European Union, the device delivers a steady hormone dose to prevent pregnancy in women of reproductive age by suppressing ovulation and altering cervical mucus.

GNH India supplies Mystrelle as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality‑assurance protocols and providing regulatory documentation for cross‑border distribution and reliable logistics support.

Manufacturer / TM Owner

Mylan Lda.

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Indications & Clinical Uses

Mystrelle, a combined estrogen‑progestogen contraceptive, is used to prevent pregnancy and manage hormone‑related menstrual conditions.

  • Contraception: prevents pregnancy by inhibiting ovulation and thickening cervical mucus.
  • Menstrual cycle regulation: helps achieve more predictable bleeding patterns and reduces cycle‑related pain.
  • Acne management: reduces androgen‑driven acne lesions in women using hormonal contraception.

How It Works

  • Ethinylestradiol binds to estrogen receptors, providing a steady estrogenic signal, while etonogestrel binds to progesterone receptors, delivering progestogenic activity. The combined hormonal exposure suppresses the hypothalamic‑pituitary‑gonadal axis, reducing gonadotropin‑releasing hormone and subsequent luteinizing hormone surge, thereby preventing ovulation. In addition, progestogen‑induced changes thicken cervical mucus and alter the endometrial lining, creating an environment unfavorable for fertilization and implantation.

Side Effects

Like all hormonal contraceptives, Mystrelle may be associated with a range of adverse reactions.

Common Side Effects

  • Vaginal discharge or irritation: mild irritation or increased discharge at the insertion site.
  • Headache: transient tension‑type or migraine‑like headaches.
  • Nausea: occasional mild nausea, especially during initial cycles.
  • Breast tenderness: temporary swelling or tenderness of the breasts.
  • Mood changes: mild mood swings or irritability.

Serious or Rare Side Effects

  • Venous thromboembolism: deep vein thrombosis or pulmonary embolism.
  • Stroke or transient ischemic attack: cerebrovascular events.
  • Hepatic adenoma: benign liver tumor development.
  • Severe allergic reaction: anaphylaxis or angioedema.
  • Hyperglycemia: significant rise in blood glucose in diabetic patients.

Precautions & Warnings

Before prescribing Mystrelle, clinicians should evaluate patient history and follow specific safety guidelines.

  • Smoking status: avoid use in women over 35 who smoke due to increased thrombotic risk.
  • Cardiovascular disease: contraindicated in patients with history of myocardial infarction or stroke.
  • Liver function: assess hepatic impairment as metabolism occurs in the liver.
  • Migraine with aura: contraindicated because of elevated stroke risk.
  • Breast cancer history: avoid in current or past estrogen‑dependent breast cancer.
  • Store at below 25°C: keep the vaginal ring in its original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Mystrelle can interact with other medicines that affect hormone metabolism or increase clotting risk.

Major Interactions (Avoid)

  • Anticoagulants: may reduce effectiveness of warfarin, requiring close INR monitoring.
  • Enzyme inducers: rifampicin, carbamazepine, phenytoin can lower hormone levels, decreasing contraceptive efficacy.
  • High‑dose SSRIs: may increase risk of serotonin syndrome when combined with hormonal agents.

Moderate Interactions (Monitor Closely)

  • Antifungals (ketoconazole, itraconazole): can increase hormone concentrations, potentially heightening side‑effect risk.
  • Antiretrovirals (efavirenz): may reduce contraceptive effectiveness.
  • Herbal supplements (St. John’s wort): may diminish hormone levels, requiring alternative contraception.

Frequently Asked Questions

Mystrelle is a combined estrogen‑progestogen contraceptive delivered via a vaginal ring. It is prescribed to prevent pregnancy in women of reproductive age by providing continuous hormonal exposure that suppresses ovulation and creates an unfavorable environment for fertilization.

Ethinylestradiol supplies estrogenic activity while etonogestrel provides progestogenic activity. Together they inhibit the hypothalamic‑pituitary‑gonadal axis, reducing the release of gonadotropins and preventing the luteinizing hormone surge needed for ovulation. The progestogen also thickens cervical mucus and alters the endometrium, reducing the chance of implantation.

The dosing regimen for Mystrelle is determined by the prescribing healthcare professional. Typically, a vaginal ring is inserted and left in place for a specified period, after which it is replaced according to the clinician’s instructions. Patients should follow the exact schedule provided by their prescriber.

Mystrelle is intended for use only when pregnancy is not present. If pregnancy occurs, the product should be discontinued and medical advice sought. During breastfeeding, hormonal contraceptives may affect milk production; clinicians usually evaluate the benefit‑risk balance before recommending use.

To request Mystrelle, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with oral combined pills, the vaginal ring provides steady hormone release without daily dosing, which can improve adherence. Unlike injectable progestogen-only methods, Mystrelle includes both estrogen and progestogen, offering broader cycle control. Its efficacy is comparable to other combined hormonal methods when used correctly.

Mystrelle should be stored at temperatures below 25 °C, protected from moisture, direct sunlight and extreme heat. Keep the ring in its original packaging until use. Do not expose the product to freezing conditions, and follow any additional handling instructions provided by the supplier.

Mystrelle is a flexible vaginal ring that is inserted into the vagina by the user or a healthcare professional. The ring remains in place for the prescribed duration (often three weeks), after which it is removed and a new ring is inserted according to the prescriber’s schedule.

Serious but rare risks include venous thromboembolism, stroke, myocardial infarction, hepatic adenoma, and severe allergic reactions such as anaphylaxis. Women with a history of clotting disorders, cardiovascular disease, smoking over age 35, or estrogen‑dependent cancers should avoid use and discuss alternatives with their clinician.

Mystrelle is contraindicated in women who are pregnant, have active breast cancer, a history of thromboembolic events, uncontrolled hypertension, severe liver disease, or who smoke cigarettes and are older than 35 years. Individuals with known hypersensitivity to any component of the ring should also avoid its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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