Product image of Nabaxor (Rivaroxaban) supplied by GNH India

Nabaxor

Active Ingredient:
Rivaroxaban
Origin:
EU

Nabaxor (Rivaroxaban)

Rivaroxaban, the active ingredient in Nabaxor, is a Direct Factor Xa Inhibitor presented as an oral tablet for oral use. It is employed to reduce the risk of stroke and systemic embolism in patients with non‑valvular atrial fibrillation and to treat or prevent deep‑vein thrombosis and pulmonary embolism.

GNH India supplies Nabaxor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand.

Manufacturer / TM Owner

Adalvo Limited

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Indications & Clinical Uses

Rivaroxaban is indicated for several thromboembolic conditions affecting the cardiovascular and venous systems.

  • Non‑valvular atrial fibrillation: reduces risk of stroke and systemic embolism.
  • Deep‑vein thrombosis (DVT): treats acute clot formation and facilitates resolution.
  • Pulmonary embolism (PE): manages acute embolic events and supports recovery.
  • Recurrent DVT/PE: prevents further thrombotic episodes after initial treatment.
  • Post‑operative prophylaxis after hip or knee replacement: lowers incidence of postoperative DVT.

How It Works

  • Rivaroxaban selectively inhibits the active site of coagulation factor Xa, a key enzyme in the conversion of prothrombin to thrombin. By blocking factor Xa, it reduces thrombin generation, limits fibrin clot formation, and thereby diminishes the risk of pathological thrombosis while preserving normal hemostasis.

Side Effects

Rivaroxaban may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Bruising or minor bleeding at sites of injury.
  • Nosebleeds or gum bleeding.
  • Headache.
  • Gastrointestinal upset such as nausea or diarrhea.

Serious or Rare Side Effects

  • Intracranial hemorrhage.
  • Major gastrointestinal bleeding.
  • Spinal or epidural hematoma, especially after neuraxial procedures.
  • Severe allergic reactions including anaphylaxis.
  • Elevated liver enzymes or hepatic dysfunction.
  • Thrombocytopenia.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific risk factors and monitor appropriately.

  • Renal function assessment: adjust therapy in severe impairment.
  • Bleeding risk evaluation: avoid in patients with active uncontrolled bleeding.
  • Concomitant antiplatelet therapy: monitor for additive bleeding risk.
  • Surgical or invasive procedures: discontinue according to recommended timing.
  • Pregnancy and lactation: use only if potential benefits outweigh risks.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Rivaroxaban interacts with several drug classes; some combinations require avoidance while others need close monitoring.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): increase plasma concentrations.
  • Strong CYP3A4 inducers (e.g., rifampin, carbamazepine): reduce anticoagulant effect.
  • Concurrent use with other anticoagulants (e.g., warfarin, heparin): markedly heightened bleeding risk.

Moderate Interactions (Monitor Closely)

  • Antiplatelet agents (e.g., aspirin, clopidogrel): additive bleeding potential.
  • Non‑steroidal anti‑inflammatory drugs (e.g., ibuprofen, naproxen): increase gastrointestinal bleeding risk.
  • Selective serotonin reuptake inhibitors (e.g., fluoxetine, sertraline): possible enhancement of bleeding.

Frequently Asked Questions

Nabaxor contains rivaroxaban and is prescribed to lower the risk of stroke and systemic embolism in patients with non‑valvular atrial fibrillation, to treat acute deep‑vein thrombosis and pulmonary embolism, to prevent recurrence of these conditions, and to provide prophylaxis against venous thromboembolism after major orthopedic surgery such as hip or knee replacement.

Rivaroxaban works by selectively inhibiting coagulation factor Xa, a pivotal enzyme in the cascade that converts prothrombin to thrombin. By blocking factor Xa, the drug reduces thrombin generation, limits fibrin clot formation, and thereby prevents the development and propagation of pathological blood clots while preserving normal clotting mechanisms.

The appropriate dose of Nabaxor is determined by the prescribing clinician based on the specific indication, patient characteristics, renal function, and other clinical factors. Dosage regimens are individualized and should follow the latest prescribing information and local regulatory guidance.

The safety of rivaroxaban during pregnancy and lactation has not been established. It is generally classified as contraindicated in pregnant women unless the potential maternal benefit justifies the potential fetal risk. Breastfeeding mothers should consult their healthcare provider, as the drug may be excreted in breast milk.

To place an order, submit an enquiry on the Nabaxor product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements if applicable), and assistance with import documentation.

Compared with warfarin, a vitamin K antagonist, rivaroxaban offers fixed dosing without routine coagulation monitoring and fewer dietary restrictions. Unlike apixaban, another direct factor Xa inhibitor, rivaroxaban has a once‑daily regimen for many indications, though both share similar efficacy and safety profiles. Choice of therapy depends on patient‑specific factors and clinician judgment.

Nabaxor tablets should be stored at ambient temperature, preferably below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in bathrooms or other humid environments.

Nabaxor is taken orally as a tablet, swallowed whole with water. It may be taken with or without food, according to the prescribing information. Patients should follow the exact timing and dosing instructions provided by their healthcare professional.

The most serious risks include major bleeding events such as intracranial hemorrhage, gastrointestinal bleeding, and spinal or epidural hematoma, especially in patients undergoing neuraxial anesthesia. Other critical concerns are severe allergic reactions and liver injury. Prompt medical attention is required if any signs of serious bleeding or hypersensitivity occur.

Nabaxor is contraindicated in individuals with active pathological bleeding, severe hepatic impairment, or a known hypersensitivity to rivaroxaban or any of its excipients. Caution is also advised for patients with uncontrolled hypertension, recent major surgery, or those receiving other anticoagulants without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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