Product image of Nac Al (Acetylcysteine) supplied by GNH India

Nac Al

Active Ingredient:
Acetylcysteine
Origin:
EU

Nac Al (Acetylcysteine)

Acetylcysteine, the active ingredient in Nac Al, is a mucolytic presented as an oral formulation for oral use. It helps to thin respiratory secretions and is used in chronic bronchitis, chronic obstructive pulmonary disease and acute respiratory tract infections.
GNH India supplies Nac Al as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aliud Pharma Gmbh

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Indications & Clinical Uses

  • Acetylcysteine acts as a mucolytic agent to improve clearance of airway secretions in several respiratory conditions.
  • Chronic bronchitis: reduces mucus viscosity and eases expectoration.
  • Chronic obstructive pulmonary disease (COPD): assists in airway clearance and may improve breathing comfort.
  • Acute respiratory tract infections: helps to loosen secretions and supports symptomatic relief.

How It Works

  • Acetylcysteine cleaves disulfide bonds within mucus glycoproteins, decreasing the viscoelasticity of sputum and facilitating its removal. It also serves as a precursor for intracellular glutathione, contributing to antioxidant protection of airway epithelium and modulating inflammatory processes.

Side Effects

Acetylcysteine may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal discomfort
  • Rash or mild skin irritation
  • Headache

Serious or Rare Side Effects

  • Anaphylactic reaction or severe hypersensitivity
  • Stevens‑Johnson syndrome or toxic epidermal necrolysis
  • Bronchospasm, especially in asthmatic patients
  • Hepatic dysfunction or elevated liver enzymes
  • Neutropenia or other blood dyscrasias

Precautions & Warnings

  • Before using acetylcysteine, consider the following safety measures.
  • Assess renal function: adjust use in patients with severe renal impairment.
  • Monitor hepatic function: watch for signs of liver enzyme elevation.
  • Use with caution in asthma: bronchospasm may occur.
  • Avoid in known hypersensitivity: discontinue if allergic reactions develop.
  • Adjust dose in elderly: consider lower doses due to altered pharmacokinetics.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Acetylcysteine can affect the activity of several concomitant medicines.

Major Interactions (Avoid)

  • Nitroglycerin: may potentiate hypotensive effects.
  • Activated charcoal: reduces acetylcysteine absorption.
  • Anticoagulants (e.g., warfarin): increased risk of bleeding.

Moderate Interactions (Monitor Closely)

  • Penicillins: possible reduction in antibacterial efficacy.
  • Carbamazepine: enzyme induction may lower acetylcysteine levels.
  • Oral contraceptives: may diminish hormonal effectiveness.

Frequently Asked Questions

Nac Al contains acetylcysteine, a mucolytic agent that helps thin and loosen thick mucus in the airways. It is commonly used to improve clearance of secretions in chronic bronchitis, chronic obstructive pulmonary disease (COPD) and acute respiratory tract infections.

Acetylcysteine breaks disulfide bonds within mucus glycoproteins, reducing the viscosity of sputum and making it easier to cough up. Additionally, it replenishes intracellular glutathione, supporting antioxidant defenses and reducing oxidative stress in the respiratory tract.

The appropriate dose of Nac Al is determined by the prescribing healthcare professional based on the patient’s condition, age, and renal or hepatic function. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for acetylcysteine in pregnancy and lactation are limited. Healthcare providers usually weigh potential benefits against possible risks before prescribing. Women who are pregnant or breastfeeding should discuss use with their physician.

To request Nac Al, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Acetylcysteine, the active ingredient in Nac Al, is a thiol‑containing mucolytic that directly cleaves mucus disulfide bonds, whereas other agents such as carbocisteine or ambroxol act mainly by stimulating serous secretion. Acetylcysteine also offers antioxidant benefits, which can be an advantage in oxidative lung injury.

Nac Al should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Nac Al is taken orally, typically as a tablet or liquid formulation, according to the prescriber’s directions. It should be swallowed with water and may be taken with or without food, unless otherwise advised by a healthcare professional.

Serious adverse reactions, although rare, include anaphylaxis, severe skin reactions such as Stevens‑Johnson syndrome, bronchospasm in susceptible individuals, and significant liver enzyme elevations. Any signs of severe allergy or respiratory distress require immediate medical attention.

Patients with known hypersensitivity to acetylcysteine or any excipients in the product should avoid Nac Al. Caution is also advised for individuals with severe asthma, uncontrolled hepatic disease, or those taking medications that may interact significantly, such as nitroglycerin or anticoagulants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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