Naclof (Diclofenac Sodium)

Diclofenac Sodium ophthalmic solution acts on ocular inflammatory pathways to manage eye conditions.

• Post‑operative ocular inflammation: reduces swelling and pain after eye surgery.
• Ocular pain: provides analgesic relief for eye discomfort.
• Allergic conjunctivitis: helps alleviate inflammation and itching associated with allergic eye reactions.

• Diclofenac Sodium inhibits cyclooxygenase (COX‑1 and COX‑2) enzymes in ocular tissues, decreasing prostaglandin synthesis. The reduction in prostaglandins limits inflammatory mediator release, leading to decreased vascular permeability, edema, and pain sensation within the eye.

Adverse ocular reactions may occur with the use of diclofenac sodium eye drops.

Common Side Effects

• Eye irritation or burning sensation
• Stinging upon instillation
• Blurred vision
• Foreign body sensation
• Conjunctival hyperemia
• Mild headache

Serious or Rare Side Effects

• Corneal ulceration or erosion
• Increased intra‑ocular pressure
• Severe allergic reaction (e.g., angio‑edema)
• Stevens‑Johnson syndrome affecting the eye
• Vision loss or significant visual impairment
• Persistent or worsening ocular inflammation

Before prescribing diclofenac sodium ophthalmic solution, clinicians should consider several safety aspects.

• Assess for ocular infection: avoid use if active infection is present.
• Hypersensitivity: do not use in patients with known allergy to diclofenac or other NSAIDs.
• Corneal disease: use with caution in patients with corneal ulcers or keratitis.
• Glaucoma: monitor intra‑ocular pressure in patients with glaucoma.
• Concurrent NSAID eye drops: avoid simultaneous use to prevent additive toxicity.
• Store at room temperature: keep in the original container, protect from light and moisture.

Diclofenac sodium eye drops can interact with other medications, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

• Concurrent ophthalmic NSAIDs: increased risk of ocular toxicity.
• Systemic NSAIDs: potential additive systemic exposure and gastrointestinal risk.
• Anticoagulants (e.g., warfarin): heightened bleeding tendency in ocular tissues.

Moderate Interactions (Monitor Closely)

• Topical corticosteroids: may mask signs of infection.
• Beta‑blocker eye drops: possible alteration of intra‑ocular pressure control.
• Contact lens wear: may increase drug absorption and irritation.