Product image of Nacrez (Desogestrel) supplied by GNH India

Nacrez

Active Ingredient:
Desogestrel
Origin:
EU

Nacrez (Desogestrel)

Desogestrel, the active ingredient in Nacrez, is a progestogen (progestin) presented as an oral tablet for oral use. It is used for the prevention of pregnancy in women of reproductive age.\n\nGNH India supplies Nacrez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Theramex Ireland Limited

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Indications & Clinical Uses

  • Desogestrel is a progestogen used in hormonal contraception to prevent pregnancy.\n\nContraception: prevents pregnancy by inhibiting ovulation and altering cervical mucus.\nFamily planning: provides reliable, reversible birth control for women.\nMenstrual regulation: may contribute to more predictable menstrual cycles when used as directed.

How It Works

  • Desogestrel is a synthetic progestogen that binds to progesterone receptors in the hypothalamus and pituitary, suppressing the luteinizing hormone surge and thereby preventing ovulation. It also induces changes in cervical mucus, making it thicker and less permeable to sperm, and alters the endometrial lining to reduce the likelihood of implantation.

Side Effects

  • Desogestrel may cause a range of adverse reactions, most of which are mild and transient.\n\nCommon Side Effects:\n- Nausea\n- Headache\n- Breast tenderness\n- Irregular vaginal bleeding\n- Weight gain\n- Mood changes\n\nSerious or Rare Side Effects:\n- Venous thromboembolism (blood clots)\n- Arterial thrombosis (stroke, myocardial infarction)\n- Severe allergic reaction (anaphylaxis)\n- Liver dysfunction or jaundice\n- Depression or severe mood disorders\n- Hypertension

Precautions & Warnings

  • Before prescribing Desogestrel, clinicians should evaluate individual risk factors and contraindications.\n\nContraindications: known or suspected pregnancy, active thromboembolic disease, severe liver disease, hormone‑dependent tumors.\nSmoking: avoid use in women over 35 who smoke due to increased cardiovascular risk.\nMedical history: assess cardiovascular, hepatic, and metabolic conditions prior to initiation.\nDrug interactions: review concomitant medications that may affect efficacy or safety.\nMonitoring: periodic blood pressure and lipid profile checks are advisable.\nStore at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

  • Desogestrel can interact with several medicines, affecting its effectiveness or safety.\n\nMajor Interactions (Avoid):\n- Strong enzyme inducers (e.g., rifampicin, carbamazepine, phenytoin) may markedly reduce contraceptive efficacy.\n- Antifungal azoles (e.g., ketoconazole) can increase plasma levels, raising risk of side effects.\n- Protease inhibitors (e.g., ritonavir) may lower effectiveness of the progestogen.\n\nModerate Interactions (Monitor Closely):\n- Selective serotonin reuptake inhibitors (SSRIs) may exacerbate mood changes.\n- Antihypertensive agents may have altered blood pressure effects due to fluid retention.\n- Herbal supplements such as St. John's wort may decrease contraceptive reliability.

Frequently Asked Questions

Nacrez contains desogestrel, a progestogen used as a hormonal contraceptive to prevent pregnancy. It works by inhibiting ovulation, thickening cervical mucus, and altering the uterine lining, providing reliable, reversible birth control for women of reproductive age.

Desogestrel binds to progesterone receptors in the brain, suppressing the luteinizing hormone surge and thereby preventing ovulation. It also makes cervical mucus thicker, reducing sperm penetration, and changes the endometrial lining to make implantation unlikely.

The specific dosing regimen for Nacrez is determined by the prescribing healthcare professional based on individual patient factors and local guidelines. Patients should follow the prescriber’s instructions and not alter the dose without medical advice.

Nacrez is contraindicated in known or suspected pregnancy because it is intended to prevent conception. Its safety during breastfeeding has not been fully established; women should discuss alternatives with their healthcare provider if they are nursing.

To request Nacrez, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nacrez (desogestrel) is a third‑generation progestogen, offering a lower risk of androgenic side effects compared with some older progestins. It provides effective contraception with a once‑daily dosing schedule, similar to other combined or progestogen‑only pills, but individual tolerance and risk profiles may differ.

Nacrez tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Nacrez is taken orally, usually once daily at the same time each day. The tablet should be swallowed whole with water and not chewed or broken. Consistency in timing helps maintain contraceptive effectiveness.

Serious risks include venous or arterial thromboembolism, severe allergic reactions, liver dysfunction, and hypertension. Women with a history of clotting disorders, smoking over age 35, or certain medical conditions should be evaluated carefully before use.

Nacrez should not be used by women who are pregnant, have active thromboembolic disease, severe liver disease, hormone‑dependent cancers, or who are known to be hypersensitive to desogestrel or any tablet excipients. Consultation with a healthcare professional is essential before starting therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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