Product image of Nacrez (Desogestrel) supplied by GNH India

Nacrez

Active Ingredient:
Desogestrel
Origin:
EU

Nacrez (Desogestrel)

Desogestrel, the active ingredient in Nacrez, is a progestin presented as an oral tablet for oral use. It is used as a progestogen‑only contraceptive to prevent pregnancy in women of reproductive age.

GNH India supplies Nacrez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality assurance and regulatory compliance across all markets. The company follows stringent manufacturing practices and provides reliable logistics for global distribution. Clients benefit from dedicated technical support, batch traceability, and flexible packaging options tailored to regional requirements.

Manufacturer / TM Owner

Theramex Ireland Limited

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Indications & Clinical Uses

  • Desogestrel is used in the progestogen‑only contraceptive pathway to prevent unintended pregnancy.
  • Contraception: prevents ovulation and thickens cervical mucus to inhibit fertilisation.
  • Family planning: offers a daily oral progestogen‑only method for women seeking estrogen‑free options.
  • Birth control: provides reliable, reversible birth control suitable for long‑term daily use.

How It Works

  • Desogestrel binds to progesterone receptors in the hypothalamic‑pituitary axis, suppressing the luteinising hormone surge and thereby inhibiting ovulation. It also induces cervical mucus changes that impede sperm penetration and alters the endometrial lining, reducing the likelihood of implantation.

Side Effects

Desogestrel may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Nausea
  • Headache
  • Breast tenderness
  • Irregular menstrual bleeding

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism
  • Severe allergic reaction (anaphylaxis)
  • Liver dysfunction or jaundice

Precautions & Warnings

Before prescribing Nacrez, clinicians should evaluate individual risk factors and counsel patients on safe use.

  • Cardiovascular assessment: avoid in women with uncontrolled hypertension or thromboembolic history.
  • Liver function: monitor in patients with hepatic impairment.
  • Smoking: advise cessation, especially in women over 35 years.
  • Pregnancy: discontinue if pregnancy is confirmed; not intended for use during pregnancy.
  • Store at ambient temperature: keep in the original pack, protect from moisture and direct sunlight.

Avoid Interactions

Desogestrel may interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Rifampicin and other strong enzyme inducers
  • Carbamazepine (antiepileptic)
  • St. John’s wort (herbal supplement)

Moderate Interactions (Monitor Closely)

  • Selective serotonin reuptake inhibitors (SSRIs)
  • Macrolide antibiotics (e.g., erythromycin)

Frequently Asked Questions

Nacrez is a progestogen‑only oral contraceptive that prevents unintended pregnancy. It is prescribed for women who need reliable birth control and prefer a hormone‑only regimen, especially when estrogen‑containing options are unsuitable.

Desogestrel binds to progesterone receptors, suppressing the luteinising hormone surge and thereby inhibiting ovulation. It also thickens cervical mucus and modifies the endometrial lining, creating conditions that reduce sperm penetration and implantation.

The specific dose and regimen are determined by the prescribing healthcare professional. In most cases, a single tablet is taken once daily at the same time each day, but the exact schedule should follow the prescriber’s instructions.

Nacrez is not intended for use during pregnancy; if pregnancy occurs, the product should be discontinued. Limited data are available for breastfeeding, and the decision to continue should be made by a healthcare provider after weighing potential risks and benefits.

To place an order, submit an enquiry on the Nacrez product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Nacrez contains desogestrel, which offers a slightly longer half‑life and may provide more flexible missed‑dose windows compared with levonorgestrel‑based pills. Both classes are effective, but individual tolerability, side‑effect profiles and patient preference guide the choice of therapy.

Store Nacrez at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct sunlight, and ensure the package is tightly closed to maintain product stability.

Nacrez is taken orally as a tablet, usually once each day at the same time. It can be taken with or without food, but consistency in timing helps maintain effective hormone levels.

Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe allergic reactions, and liver dysfunction. Patients should seek immediate medical attention if they experience unexplained swelling, shortness of breath, severe rash, or jaundice.

Nacrez is contraindicated in women with known or suspected pregnancy, active or past thromboembolic disease, severe liver disease, uncontrolled hypertension, or known hypersensitivity to desogestrel or any tablet excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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