Product image of Nacrez (Desogestrel) supplied by GNH India

Nacrez

Active Ingredient:
Desogestrel
Origin:
EU

Nacrez (Desogestrel)

Desogestrel, the active ingredient in Nacrez, is a progestogen presented as an oral tablet for oral use. It is employed as a hormonal contraceptive to prevent pregnancy in women of reproductive age and works by suppressing ovulation and altering the endometrial lining, providing reliable birth control.

GNH India supplies Nacrez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Theramex Ireland Limited

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Indications & Clinical Uses

Desogestrel, marketed as Nacrez, is indicated for hormonal contraception and related menstrual management.

  • Prevention of pregnancy: provides reliable contraception by inhibiting ovulation.
  • Menstrual cycle regulation: helps achieve predictable withdrawal bleeding patterns.
  • Estrogen‑free contraceptive option: offers a progestogen‑only method for women who cannot use estrogen‑containing products.

How It Works

  • Desogestrel acts as a selective progesterone receptor agonist. By binding to progesterone receptors in the hypothalamus and pituitary, it suppresses the luteinizing hormone surge, thereby preventing ovulation. It also induces changes in the cervical mucus and endometrial lining, reducing sperm penetration and implantation potential, which together ensure effective hormonal contraception.

Side Effects

Desogestrel may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Irregular vaginal bleeding or spotting.
  • Headache.
  • Nausea.
  • Breast tenderness.
  • Weight gain.
  • Mood changes.

Serious or Rare Side Effects

  • Deep vein thrombosis or pulmonary embolism.
  • Severe allergic reaction (anaphylaxis).
  • Liver dysfunction or jaundice.
  • Depression or severe mood disorders.
  • Hypertension.
  • Unexplained vaginal bleeding.

Precautions & Warnings

Before prescribing Nacrez, clinicians should evaluate individual risk factors and counsel patients on safe use.

  • Assess medical history: evaluate risk factors for thromboembolism.
  • Avoid use in known estrogen‑dependent tumors.
  • Monitor blood pressure: watch for hypertension.
  • Consider liver function: adjust if hepatic impairment is present.
  • Counsel on smoking: avoid in women over 35 who smoke more than 15 cigarettes per day.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Desogestrel can interact with several drug classes, altering its contraceptive efficacy or increasing adverse effects.

Major Interactions (Avoid)

  • Antiepileptic enzyme inducers (e.g., carbamazepine, phenytoin): reduce contraceptive effectiveness.
  • Rifampicin: decreases plasma levels of desogestrel.
  • St. John’s wort: may lower contraceptive efficacy.

Moderate Interactions (Monitor Closely)

  • Antifungal azoles (e.g., ketoconazole): may increase desogestrel levels.
  • Antiretroviral protease inhibitors (e.g., ritonavir): may affect metabolism.
  • Combined hormonal therapy (estrogen): may increase risk of thromboembolism.

Frequently Asked Questions

Nacrez contains desogestrel, a progestogen‑only hormone used as a prescription contraceptive. It is indicated to prevent unintended pregnancy in women of reproductive age by suppressing ovulation and modifying the uterine environment, providing an estrogen‑free birth‑control option.

Desogestrel binds selectively to progesterone receptors in the hypothalamus and pituitary, inhibiting the luteinizing hormone surge that triggers ovulation. It also thickens cervical mucus and alters the endometrial lining, making it less receptive to implantation, thereby delivering effective contraception.

The dosing regimen for Nacrez is determined by the prescribing clinician. Typically, it is taken as one oral tablet daily at the same time each day, but the exact strength, timing, and duration are individualized based on the patient’s medical profile.

Nacrez is not intended for use during pregnancy and should be discontinued if pregnancy occurs. Safety data for breastfeeding are limited; clinicians usually advise caution and may recommend alternative contraception for nursing mothers, weighing potential risks and benefits.

To order Nacrez, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Nacrez offers a progestogen‑only option, which is advantageous for women who cannot use estrogen‑containing pills due to contraindications such as migraine with aura or thrombotic risk. Compared with combined oral contraceptives, it may have a slightly higher rate of breakthrough bleeding but carries a lower risk of estrogen‑related side effects.

Nacrez tablets should be stored at ambient temperature, below 25 °C, in their original container to protect from moisture and light. Keep the product out of reach of children and avoid storing in areas with high humidity or direct sunlight.

Nacrez is taken orally, usually as a single tablet each day. Patients should swallow the tablet whole with water and aim to take it at the same time each day to maintain consistent hormone levels and maximize contraceptive effectiveness.

Serious risks include thromboembolic events such as deep‑vein thrombosis or pulmonary embolism, severe allergic reactions, liver dysfunction, and significant hypertension. Patients should seek immediate medical attention if they experience unexplained leg pain, shortness of breath, severe abdominal pain, jaundice, or signs of an allergic reaction.

Nacrez is contraindicated in women with known or suspected pregnancy, active liver disease, unexplained vaginal bleeding, or a history of thromboembolic disorders. It should also be avoided in individuals with hypersensitivity to desogestrel or any of the tablet’s excipients.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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