Product image of Nacrez (Desogestrel) supplied by GNH India

Nacrez

Active Ingredient:
Desogestrel
Origin:
EU

Nacrez (Desogestrel)

Desogestrel, the active ingredient in Nacrez, is a progestin presented as an oral dosage form for oral use. It is prescribed to prevent pregnancy and to provide hormonal regulation in women of reproductive age.

GNH India supplies Nacrez as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Theramex Ireland Limited

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Indications & Clinical Uses

Desogestrel is a progestin used in hormonal contraceptive therapy and related reproductive health pathways.

  • Contraception: prevents pregnancy in women of reproductive age.
  • Hormonal contraceptive: offers a progestin‑only oral method for family planning.
  • Cycle control: helps regulate menstrual bleeding patterns when used as prescribed.

How It Works

  • Desogestrel binds to progesterone receptors, suppressing the mid‑cycle luteinizing hormone surge, thereby preventing ovulation. It also induces cervical mucus changes that impede sperm penetration and alters the endometrial lining to reduce the likelihood of implantation.

Side Effects

Desogestrel may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea: mild stomach upset.
  • Headache: occasional tension‑type headaches.
  • Breast tenderness: temporary discomfort.
  • Weight gain: modest increase in body weight.
  • Mood changes: irritability or mood swings.
  • Irregular bleeding: spotting or breakthrough bleeding.

Serious or Rare Side Effects

  • Venous thromboembolism: blood clots in deep veins.
  • Severe allergic reaction: rash, swelling, or anaphylaxis.
  • Liver dysfunction: jaundice or abnormal liver enzymes.
  • Depression: new or worsening depressive symptoms.
  • Hypertension: significant rise in blood pressure.
  • Visual disturbances: rare changes in vision.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Medical history: disclose clotting disorders, liver disease, or hypertension.
  • Smoking: avoid use if over 35 years old and a smoker.
  • Medication review: discuss all concurrent drugs, especially enzyme inducers.
  • Pregnancy and lactation: discontinue if pregnancy occurs; consult a physician before breastfeeding.
  • Regular monitoring: schedule follow‑up visits for blood pressure and menstrual changes.
  • Store at ambient temperature: keep below 25 °C, retain original packaging, and protect from moisture.

Avoid Interactions

Desogestrel can interact with several medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce contraceptive effectiveness.
  • Antifungal azoles (e.g., ketoconazole): may increase plasma concentrations.
  • Protease inhibitor antiretrovirals: can alter hormone levels.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline): may slightly diminish efficacy.
  • St. John’s wort: herbal supplement that can decrease hormone levels.
  • Anticonvulsants (e.g., phenytoin): may affect hormonal activity.

Frequently Asked Questions

Nacrez is prescribed as a hormonal contraceptive containing desogestrel. It is used to prevent pregnancy in women of reproductive age and can also help regulate menstrual bleeding patterns when taken as directed by a healthcare professional.

Desogestrel acts by binding to progesterone receptors, suppressing the luteinizing hormone surge that triggers ovulation. It also thickens cervical mucus and alters the endometrial lining, creating an environment that is hostile to sperm and reduces the chance of implantation.

The specific dose and dosing schedule are determined by the prescribing clinician. Typically, desogestrel‑containing contraceptives are taken once daily, but the exact regimen should follow the healthcare provider’s instructions.

Nacrez is not intended for use during pregnancy; it should be discontinued if pregnancy is confirmed. While limited data exist for breastfeeding, the decision to continue or stop therapy should be made in consultation with a physician, weighing potential risks and benefits.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Nacrez contains a progestin‑only formulation, which differs from combined oral contraceptives that include estrogen. Progestin‑only pills are often preferred for women who cannot take estrogen, have certain cardiovascular risk factors, or are breastfeeding, offering effective contraception with a lower risk of estrogen‑related side effects.

Store Nacrez at ambient temperature, preferably below 25 °C. Keep the tablets in their original blister pack, protect them from moisture and direct sunlight, and ensure they are out of reach of children.

Nacrez is taken orally, usually with a glass of water, at the same time each day. Consistent daily intake helps maintain steady hormone levels and maximizes contraceptive effectiveness.

Serious risks include venous thromboembolism (blood clots), severe allergic reactions, liver dysfunction, and significant mood changes such as depression. Patients should seek immediate medical attention if they experience symptoms like unexplained swelling, severe abdominal pain, jaundice, or persistent mood disturbances.

Nacrez is contraindicated in women with known clotting disorders, active liver disease, current pregnancy, or those who are breastfeeding without medical guidance. It should also be avoided by smokers over 35 years of age and by individuals with uncontrolled hypertension.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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