Product image of Nadilaz (Azelastine Hydrochloride, Fluticasone Propionate) supplied by GNH India

Nadilaz

Active Ingredient:
Azelastine Hydrochloride, Fluticasone Propionate
Origin:
EU

Nadilaz (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine hydrochloride / fluticasone propionate, the active ingredients in Nadilaz, are an intranasal antihistamine and corticosteroid combination presented as a nasal spray for nasal use. It treats allergic rhinitis, including seasonal forms, in patients requiring prescription therapy.

GNH India supplies Nadilaz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Ace Pharmaceuticals Bv

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Indications & Clinical Uses

  • Nadilaz is indicated for allergic rhinitis and works on the nasal inflammatory pathway to relieve symptoms.
  • Allergic rhinitis: reduces nasal congestion, itching, sneezing and rhinorrhea.
  • Seasonal allergic rhinitis: controls symptoms triggered by pollen or seasonal allergens.
  • Perennial allergic rhinitis: provides year‑round relief from allergen‑induced nasal inflammation.

How It Works

  • Azelastine hydrochloride blocks H1 histamine receptors and exerts anti‑inflammatory effects, while fluticasone propionate activates glucocorticoid receptors, suppressing cytokine production, eosinophil infiltration and vascular permeability in the nasal mucosa, together reducing allergic inflammation and symptom expression.

Side Effects

Adverse reactions may occur with intranasal use of Nadilaz.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Headache.
  • Bitter taste.
  • Epistaxis (nosebleed).
  • Throat irritation.
  • Cough.

Serious or Rare Side Effects

  • Nasal septal perforation.
  • Severe or prolonged epistaxis.
  • Adrenal suppression with prolonged high‑dose use.
  • Hypersensitivity reactions including angioedema.
  • Opportunistic fungal infection of the nasal passages.
  • Visual disturbances such as blurred vision.

Precautions & Warnings

  • Before using Nadilaz, consider the following safety measures.
  • Pregnancy: consult a prescriber; limited safety data are available.
  • Breastfeeding: weigh potential benefits against possible risks to the infant.
  • Concomitant nasal surgery: postpone use until the surgical site has healed.
  • Use in children: follow age‑specific labeling and dosing recommendations.
  • Hypersensitivity: avoid if known allergy to azelastine, fluticasone, or any excipients.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Nadilaz may interact with other medicines; monitor patients accordingly.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may increase systemic fluticasone exposure.
  • Live vaccines: systemic corticosteroid effect could reduce vaccine efficacy.
  • Monoamine oxidase inhibitors: additive antihistamine effects may increase sedation.

Moderate Interactions (Monitor Closely)

  • Oral antihistamines: may enhance sedation or anticholinergic effects.
  • Beta‑blockers: could mask signs of severe allergic reactions.
  • Nasal decongestants: overuse may lead to rebound congestion.

Frequently Asked Questions

Nadilaz is a prescription nasal spray that combines azelastine hydrochloride and fluticasone propionate to treat allergic rhinitis, including both seasonal and perennial forms. It helps relieve nasal congestion, itching, sneezing, and runny nose by targeting the underlying inflammatory response in the nasal passages.

Azelastine hydrochloride is an H1‑receptor antagonist that blocks the action of histamine, a key mediator of allergic symptoms. In addition to antihistamine activity, it possesses anti‑inflammatory properties that reduce nasal mucosal edema and the release of inflammatory mediators.

The dosing regimen for Nadilaz is determined by the prescribing healthcare professional based on the patient’s age, severity of symptoms, and clinical response. The prescriber will provide specific instructions on the number of sprays per nostril and the frequency of administration.

Safety data for Nadilaz in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To request Nadilaz, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will verify trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Nadilaz combines an antihistamine (azelastine) with a corticosteroid (fluticasone) in a single spray, offering both rapid symptom relief and long‑term anti‑inflammatory control. Compared with single‑agent antihistamine sprays, it may provide superior reduction of nasal congestion, while offering a more convenient option than using separate antihistamine and steroid products.

Store Nadilaz at room temperature, preferably below 25 °C, in its original packaging. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and avoid freezing. Do not use the product after the expiration date printed on the label.

Nadilaz is administered as a nasal spray. The patient should gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril, and press the actuator to deliver the prescribed number of sprays. The process is then repeated in the other nostril if directed by the prescriber.

Serious adverse events, although rare, can include nasal septal perforation, severe or prolonged nosebleeds, adrenal suppression with prolonged high‑dose use, hypersensitivity reactions such as angioedema, opportunistic fungal infections of the nasal passages, and visual disturbances. Patients should seek medical attention if any of these occur.

Nadilaz should be avoided in individuals with known hypersensitivity to azelastine, fluticasone, or any of the excipients in the formulation. It is also contraindicated in patients who have had recent nasal surgery until the site has healed, and in those for whom systemic corticosteroid therapy is contraindicated.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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