Product image of Nadilaz (Azelastine Hydrochloride, Fluticasone Propionate) supplied by GNH India

Nadilaz

Active Ingredient:
Azelastine Hydrochloride, Fluticasone Propionate
Origin:
EU

Nadilaz (Azelastine Hydrochloride, Fluticasone Propionate)

Azelastine Hydrochloride, the active ingredient in Nadilaz, is an antihistamine/corticosteroid combination presented as a nasal formulation for intranasal use. It is indicated for the treatment of allergic rhinitis, including seasonal and perennial forms, by reducing nasal congestion, itching and sneezing in affected individuals.

GNH India supplies Nadilaz as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution for this prescription nasal product, ensuring consistent availability across diverse markets.

Manufacturer / TM Owner

Ace Pharmaceuticals Bv

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Indications & Clinical Uses

  • Nadilaz, a nasal antihistamine/corticosteroid combination, is used to manage allergic inflammation of the nasal passages.
  • Allergic rhinitis: provides relief of nasal congestion, itching, sneezing and rhinorrhea associated with allergic triggers.
  • Seasonal allergic rhinitis: reduces symptoms during pollen or mold seasons, improving daily comfort and function.
  • Perennial allergic rhinitis: controls year‑round nasal allergy symptoms, helping maintain consistent airway patency.

How It Works

  • Azelastine Hydrochloride acts as a selective H1‑histamine receptor antagonist, preventing histamine‑mediated vasodilation and sensory nerve activation in the nasal mucosa. Fluticasone Propionate is a potent synthetic glucocorticoid that binds intracellular glucocorticoid receptors, modulating gene transcription to suppress production of inflammatory cytokines, chemokines and adhesion molecules. The combined action reduces both immediate histamine‑driven responses and delayed inflammatory processes, resulting in decreased nasal edema, mucus production and allergic symptom severity.

Side Effects

Nasal administration of Nadilaz may be associated with a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Taste alteration: bitter or unpleasant taste in the mouth.
  • Nasal irritation: mild burning or stinging sensation.
  • Headache: transient mild headache.
  • Epistaxis: occasional mild nosebleeds.

Serious or Rare Side Effects

  • Severe allergic reaction: anaphylaxis, facial swelling, or difficulty breathing.
  • Cortisol suppression: signs of adrenal insufficiency with prolonged use.
  • Nasal septum perforation: rare tissue damage leading to perforation.

Precautions & Warnings

Before prescribing Nadilaz, clinicians should consider several precautionary measures to ensure safe use.

  • Assess medical history: evaluate for hypersensitivity to azelastine, fluticasone or any excipients.
  • Monitor for infection: avoid use in patients with active nasal or sinus infections without physician guidance.
  • Limit duration: use the lowest effective dose for the shortest period necessary to control symptoms.
  • Avoid concurrent nasal sprays: do not combine with other intranasal medications unless directed.
  • Store at room temperature: keep below 25 °C in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Nadilaz can interact with other medicines, and interactions are classified by their clinical significance.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors: may increase systemic exposure to fluticasone, raising risk of corticosteroid‑related effects.
  • Live vaccines: intranasal corticosteroids may diminish immune response; avoid concurrent administration.

Moderate Interactions (Monitor Closely)

  • Other antihistamines: additive sedation or anticholinergic effects may occur.
  • Systemic corticosteroids: combined systemic effects could enhance cortisol‑related adverse events.

Frequently Asked Questions

Nadilaz is a prescription nasal spray that combines azelastine hydrochloride and fluticasone propionate to treat allergic rhinitis. It helps relieve nasal congestion, itching, sneezing and runny nose caused by seasonal or perennial allergens, providing symptom control for patients with allergic nasal inflammation.

Azelastine is a selective H1‑histamine receptor antagonist. By blocking these receptors on nasal blood vessels and sensory nerves, it prevents histamine‑induced vasodilation, increased permeability and nerve stimulation, which reduces the immediate allergic symptoms such as itching, sneezing and watery discharge.

The dosage of Nadilaz is determined by the prescribing clinician based on the patient’s age, severity of symptoms and response to therapy. The prescriber will specify the number of sprays per nostril and the frequency, typically following the product’s labeling guidelines.

Safety data for Nadilaz in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against any possible risks and consider alternative treatments if appropriate. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their physician.

To order Nadilaz, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and assistance with import documentation.

Nadilaz combines an antihistamine (azelastine) with a corticosteroid (fluticasone), offering both rapid relief of histamine‑mediated symptoms and longer‑term anti‑inflammatory control. Compared with monotherapy antihistamines or corticosteroids alone, the combination can provide more comprehensive symptom management, especially in patients with moderate to severe allergic rhinitis.

Nadilaz should be stored at room temperature, below 25 °C, in its original packaging. Keep the bottle tightly closed, protect it from moisture and direct sunlight, and avoid freezing. Do not refrigerate the product unless the manufacturer’s label specifically advises otherwise.

Nadilaz is administered as a nasal spray. The patient should gently blow the nose, tilt the head slightly forward, insert the nozzle into one nostril, and spray the prescribed number of sprays while breathing in gently. The same procedure is repeated in the other nostril if required.

Serious risks include severe allergic reactions such as anaphylaxis, systemic corticosteroid effects like adrenal suppression with prolonged use, and rare complications such as nasal septum perforation. Patients should seek immediate medical attention if they experience difficulty breathing, facial swelling, severe nosebleeds or signs of hormonal imbalance.

Nadilaz is contraindicated in individuals with known hypersensitivity to azelastine, fluticasone, or any of the formulation’s excipients. It should also be avoided in patients with active untreated nasal infections or recent nasal surgery unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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